3.4.21.118: kallikrein 8
This is an abbreviated version!
For detailed information about kallikrein 8, go to the full flat file.
Word Map on EC 3.4.21.118
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3.4.21.118
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kallikreins
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klk8
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melanopsin
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desquamation
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photopigment
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iprgcs
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non-visual
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peropsin
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medicine
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biotechnology
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molecular biology
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pharmacology
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analysis
- 3.4.21.118
- kallikreins
- klk8
- melanopsin
-
desquamation
-
photopigment
-
iprgcs
-
non-visual
-
peropsin
- medicine
- biotechnology
- molecular biology
- pharmacology
- analysis
Reaction
cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys =
Synonyms
Alzheimers associated protease, brain serine protease 1, GK-8, hK8, kallikrein 8, kallikrein 8 protease, kallikrein-8, kallikrein-related peptidase, kallikrein-related peptidase 8, kallikrein-related peptidase-8, KLK8, KRP/hK8, mK8, neuropsin, NP, ovasin, P1 kallikrein, PRSS19, RGK-8, S01.244, TADG-14, TADG14, tissue kallikrein, type I neuropsin, type II neuropsin
ECTree
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Reference on EC 3.4.21.118 - kallikrein 8
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (O60259), Rattus norvegicus (O88780), Rattus norvegicus (P36374), Mus musculus (P07628), Mus musculus (Q61955)
Kishi, T.; Kato, M.; Shimizu, T.; Kato, K.; Matsumoto, K.; Yoshida, S.; Shiosaka, S.; Hakoshima, T.
Crystallization and preliminary X-ray analysis of neuropsin, a serine protease expressed in the limbic system of mouse brain
J. Struct. Biol.
118
248-251
1997
Mus musculus (Q61955), Mus musculus
Yoshida, S.; Taniguchi, M.; Hirata, A.; Shiosaka, S.
Sequence analysis and expression of human neuropsin cDNA and gene
Gene
213
9-16
1998
Homo sapiens (O60259), Homo sapiens, Mus musculus (Q61955), Mus musculus
Shimizu, C.; Yoshida, S.; Shibata, M.; Kato, K.; Momota, Y.; Matsumoto, K.; Shiosaka, T.; Midorikawa, R.; Kamachi, T.; Kawabe, A.; Shiosaka, S.
Characterization of recombinant and brain neuropsin, a plasticity-related serine protease
J. Biol. Chem.
273
11189-11196
1998
Mus musculus (Q61955), Mus musculus
Underwood, L.J.; Tanimoto, H.; Wang, Y.; Shigemasa, K.; Parmley, T.H.; O'Brien, T.J.
Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma
Cancer Res.
59
4435-4439
1999
Homo sapiens (O60259)
Kishi, T.; Kato, M.; Shimizu, T.; Kato, K.; Matsumoto, K.; Yoshida, S.; Shiosaka, S.; Hakoshima, T.
Crystal structure of neuropsin, a hippocampal protease involved in kindling epileptogenesis
J. Biol. Chem.
274
4220-4224
1999
Mus musculus (Q61955), Mus musculus
Tani, N.; Matsumoto, K.; Ota, I.; Yoshida, S.; Takada, Y.; Shiosaka, S.; Matsuura, N.
Effects of fibronectin cleaved by neuropsin on cell adhesion and migration
Neurosci. Res.
39
247-251
2001
Mus musculus (Q61955), Mus musculus
Kato, K.; Kishi, T.; Kamachi, T.; Akisada, M.; Oka, T.; Midorikawa, R.; Takio, K.; Dohmae, N.; Bird, P.I.; Sun, J.; Scott, F.; Miyake, Y.; Yamamoto, K.; Machida, A.; Tanaka, T.; Matsumoto, K.; Shibata, M.; Shiosaka, S.
Serine proteinase inhibitor 3 and murinoglobulin I are potent inhibitors of neuropsin in adult mouse brain
J. Biol. Chem.
276
14562-14571
2001
Mus musculus (Q61955), Mus musculus
Oka, T.; Hakoshima, T.; Itakura, M.; Yamamori, S.; Takahashi, M.; Hashimoto, Y.; Shiosaka, S.; Kato, K.
Role of loop structures of neuropsin in the activity of serine protease and regulated secretion
J. Biol. Chem.
277
14724-14730
2002
Mus musculus (Q61955), Mus musculus
Matsumoto-Miyai, K.; Kitagawa, R.; Ninomiya, A.; Momota, Y.; Yoshida, S.; Shiosaka, S.
Decidualization induces the expression and activation of an extracellular protease neuropsin in mouse uterus
Biol. Reprod.
67
1414-1418
2002
Mus musculus (Q61955), Mus musculus
El Moujahed, A.; Gutman, N.; Brillard, M.; Gauthier, F.
Substrate specificity of two kallikrein family gene products isolated from the rat submandibular gland
FEBS Lett.
265
137-140
1990
Rattus norvegicus
Yousef, G.M.; Diamandis, E.P.
The new human tissue kallikrein gene family: structure, function, and association to disease
Endocr. Rev.
22
184-204
2001
Homo sapiens (O60259)
Chen, Z.L.; Yoshida, S.; Kato, K.; Momota, Y.; Suzuki, J.; Tanaka, T.; Ito, J.; Nishino, H.; Aimoto, S.; Kiyama, H.; Shiosaka, S.
Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus
J. Neurosci.
15
5088-5097
1995
Mus musculus (Q61955), Mus musculus
Kishi, T.; Cloutier, S.M.; Kuendig, C.; Deperthes, D.; Diamandis, E.P.
Activation and enzymatic characterization of recombinant human kallikrein 8
Biol. Chem.
387
723-731
2006
Homo sapiens (O60259), Homo sapiens
Borgono, C.A.; Kishi, T.; Scorilas, A.; Harbeck, N.; Dorn, J.; Schmalfeldt, B.; Schmitt, M.; Diamandis, E.P.
Human kallikrein 8 protein is a favorable prognostic marker in ovarian cancer
Clin. Cancer Res.
12
1487-1493
2006
Homo sapiens
Rajapakse, S.; Ogiwara, K.; Takano, N.; Moriyama, A.; Takahashi, T.
Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins
FEBS Lett.
579
6879-6884
2005
Homo sapiens (O60259), Homo sapiens
Nakamura, Y.; Tamura, H.; Horinouchi, K.; Shiosaka, S.
Role of neuropsin in formation and maturation of Schaffer-collateral L1cam-immunoreactive synaptic boutons
J. Cell Sci.
119
1341-1349
2006
Mus musculus
Tamura, H.; Ishikawa, Y.; Hino, N.; Maeda, M.; Yoshida, S.; Kaku, S.; Shiosaka, S.
Neuropsin is essential for early processes of memory acquisition and Schaffer collateral long-term potentiation in adult mouse hippocampus in vivo
J. Physiol.
570
541-551
2006
Mus musculus
Li, Y.; Qian, Y.P.; Yu, X.J.; Wang, Y.Q.; Dong, D.G.; Sun, W.; Ma, R.M.; Su, B.
Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory
Mol. Biol. Evol.
21
2111-2115
2004
Homo sapiens (O60259), Homo sapiens
Shigemasa, K.; Tian, X.; Gu, L.; Tanimoto, H.; Underwood, L.J.; OBrien, T.J.; Ohama, K.
Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer
Oncol. Rep.
11
1153-1159
2004
Homo sapiens
Sher, Y.P.; Chou, C.C.; Chou, R.H.; Wu, H.M.; Wayne Chang, W.S.; Chen, C.H.; Yang, P.C.; Wu, C.W.; Yu, C.L.; Peck, K.
Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness
Cancer Res.
66
11763-11770
2006
Homo sapiens
Lu, Z.X.; Peng, J.; Su, B.
A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory
Hum. Mutat.
28
978-984
2007
Homo sapiens (O60259), Homo sapiens, Macaca mulatta (Q5V9S7), Pan troglodytes (Q5V9U8)
Singh, J.; Naran, A.; Misso, N.L.; Rigby, P.J.; Thompson, P.J.; Bhoola, K.D.
Expression of kallikrein-related peptidases (KRP/hK5, 7, 6, 8) in subtypes of human lung carcinoma
Int. Immunopharmacol.
8
300-306
2008
Homo sapiens
Scott, F.L.; Sun, J.; Whisstock, J.C.; Kato, K.; Bird, P.I.
SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes
J. Biochem.
142
435-442
2007
Homo sapiens, Mus musculus
Kishibe, M.; Bando, Y.; Terayama, R.; Namikawa, K.; Takahashi, H.; Hashimoto, Y.; Ishida-Yamamoto, A.; Jiang, Y.P.; Mitrovic, B.; Perez, D.; Iizuka, H.; Yoshida, S.
Kallikrein 8 is involved in skin desquamation in cooperation with other kallikreins
J. Biol. Chem.
282
5834-5841
2007
Mus musculus, Mus musculus C57BL/6
Ishikawa, Y.; Horii, Y.; Tamura, H.; Shiosaka, S.
Neuropsin (KLK8)-dependent and -independent synaptic tagging in the Schaffer-collateral pathway of mouse hippocampus
J. Neurosci.
28
843-849
2008
Mus musculus
Pettus, J.R.; Johnson, J.J.; Shi, Z.; Davis, J.W.; Koblinski, J.; Ghosh, S.; Liu, Y.; Ravosa, M.J.; Frazier, S.; Stack, M.S.
Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity
Histol. Histopathol.
24
197-207
2009
Homo sapiens, Mus musculus
Chow, T.F.; Crow, M.; Earle, T.; El-Said, H.; Diamandis, E.P.; Yousef, G.M.
Kallikreins as microRNA targets: an in silico and experimental-based analysis
Biol. Chem.
389
731-738
2008
Homo sapiens
Lu, Z.X.; Huang, Q.; Su, B.
Functional characterization of the human-specific (type II) form of kallikrein 8, a gene involved in learning and memory
Cell Res.
19
259-267
2009
Homo sapiens
Planque, C.; Li, L.; Zheng, Y.; Soosaipillai, A.; Reckamp, K.; Chia, D.; Diamandis, E.P.; Goodglick, L.
A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma
Clin. Cancer Res.
14
1355-1362
2008
Homo sapiens
Yoshida, S.
Klk8, a multifunctional protease in the brain and skin: analysis of knockout mice
Biol. Chem.
391
375-380
2010
Mus musculus
Ohler, A.; Debela, M.; Wagner, S.; Magdolen, V.; Becker-Pauly, C.
Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation
Biol. Chem.
391
455-460
2010
Homo sapiens
Shingaki, K.; Matsuzaki, S.; Taniguchi, M.; Kubo, T.; Fujiwara, T.; Yamamoto, A.; Tamura, H.; Maeda, T.; Ooi, K.; Matsumoto, K.; Shiosaka, S.; Tohyama, M.
Molecular mechanism of kallikrein-related peptidase 8/neuropsin-induced hyperkeratosis in inflamed skin
Br. J. Dermatol.
163
466-475
2010
Homo sapiens, Mus musculus
Eissa, A.; Amodeo, V.; Smith, C.R.; Diamandis, E.P.
Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade
J. Biol. Chem.
286
687-706
2011
Homo sapiens
Ramachandran, R.; Eissa, A.; Mihara, K.; Oikonomopoulou, K.; Saifeddine, M.; Renaux, B.; Diamandis, E.; Hollenberg, M.D.
Proteinase-activated receptors (PARs): differential signalling by kallikrein-related peptidases KLK8 and KLK14
Biol. Chem.
393
421-427
2012
Homo sapiens
Azam, S.; Raza, S.
Structure modeling and hybrid virtual screening study of Alzheimers associated protease kallikrein 8 for the identification of novel inhibitors
Med. Chem. Res.
23
3516-3527
2014
Homo sapiens
-
Iinuma, S.; Kishibe, M.; Saito, N.; Igawa, S.; Honma, M.; Takahashi, H.; Bando, Y.; Yoshida, S.; Iizuka, H.; Ishida-Yamamoto, A.
Klk8 is required for microabscess formation in a mouse imiquimod model of psoriasis
Exp. Dermatol.
24
887-889
2015
Mus musculus (Q61955)
Wang, H.; Lin, C.; Pan, T.; Yeh, C.
Increase of serum kallikrein-8 level after long-term telbivudine treatment
In Vivo
32
955-960
2018
Homo sapiens (O60259), Homo sapiens
Raza, S.; Ranaghan, K.E.; van der Kamp, M.W.; Woods, C.J.; Mulholland, A.J.; Azam, S.S.
Visualizing protein-ligand binding with chemical energy-wise decomposition (CHEWD) application to ligand binding in the kallikrein-8 S1 site
J. Comput. Aided Mol. Des.
33
461-475
2019
Homo sapiens (O60259)
Cerqueira, C.; Samperio Ventayol, P.; Vogeley, C.; Schelhaas, M.
Kallikrein-8 proteolytically processes human papillomaviruses in the extracellular space to facilitate entry into host cells
J. Virol.
89
7038-7052
2015
Homo sapiens (O60259), Homo sapiens
Cao, B.; Yu, Q.; Zhao, W.; Tang, Z.; Cong, B.; Du, J.; Lu, J.; Zhu, X.; Ni, X.
Kallikrein-related peptidase 8 is expressed in myocardium and induces cardiac hypertrophy
Sci. Rep.
7
20024
2016
Rattus norvegicus (O88780)
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