3.4.21.118: kallikrein 8

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For detailed information about kallikrein 8, go to the full flat file.

Reaction

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys =

Synonyms

Alzheimers associated protease, brain serine protease 1, GK-8, hK8, kallikrein 8, kallikrein 8 protease, kallikrein-8, kallikrein-related peptidase, kallikrein-related peptidase 8, kallikrein-related peptidase-8, KLK8, KRP/hK8, mK8, neuropsin, NP, ovasin, P1 kallikrein, PRSS19, RGK-8, S01.244, TADG-14, TADG14, tissue kallikrein, type I neuropsin, type II neuropsin

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.118 kallikrein 8

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Results	in table
6	Activating Compound
7	AA Sequence
14	Application
2	CAS Registry Number
13	Cloned(Commentary)
2	Crystallization (Commentary)
352	Disease/ Diagnostics
7	Expression
9	General Information
1	General Stability
45	Inhibitors
11	kcat/KM [mM/s]
1	Ki Value [mM]
28	KM Value [mM]
11	Localization
6	Metals/Ions
10	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
198	Organism
5	PDB ID
9	pH Optimum
3	pH Range
8	Posttranslational Modification
17	Protein Variants
7	Purification (Commentary)
11	Reaction
2	Reaction Type
51	Reference
88	Source Tissue
3	Specific Activity [micromol/min/mg]
3	Storage Stability
116	Substrates and Products (Substrate)
8	Subunits
70	Synonyms
6	Temperature Optimum [°C]
21	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.4.21.118 - kallikrein 8

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MOLECULAR WEIGHT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

10000

Rattus norvegicus

-

x * 10000 + x * 18000, SDS-PAGE

647331

18000

Rattus norvegicus

-

x * 10000 + x * 18000, SDS-PAGE

647331

26000

Mus musculus

Q61955

1 * 26000, non-reducing SDS-PAGE

647323

26600

Mus musculus

Q61955

recombinant enzyme, MALDI-TOF MS

647323

28520

Mus musculus

Q61955

precursor, calculated from sequence of cDNA

659764

29000

Mus musculus

Q61955

recombinant enzyme, gel filtration

647323

30000

Homo sapiens

O60259

x * 30000, SDS-PAGE

647324

31500

Homo sapiens

O60259

x * 31500, SDS-PAGE of active recombinant enzyme

668625

32000

Mus musculus

Q61955

1 * 32000, reducing SDS-PAGE

647323

35000

Homo sapiens

-

immunoblotting

680558