3.4.21.118: kallikrein 8

This is an abbreviated version!
For detailed information about kallikrein 8, go to the full flat file.

Reaction

cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys =

Synonyms

Alzheimers associated protease, brain serine protease 1, GK-8, hK8, kallikrein 8, kallikrein 8 protease, kallikrein-8, kallikrein-related peptidase, kallikrein-related peptidase 8, kallikrein-related peptidase-8, KLK8, KRP/hK8, mK8, neuropsin, NP, ovasin, P1 kallikrein, PRSS19, RGK-8, S01.244, TADG-14, TADG14, tissue kallikrein, type I neuropsin, type II neuropsin

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.118 kallikrein 8

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Results	in table
6	Activating Compound
7	AA Sequence
14	Application
2	CAS Registry Number
13	Cloned(Commentary)
2	Crystallization (Commentary)
352	Disease/ Diagnostics
7	Expression
9	General Information
1	General Stability
45	Inhibitors
11	kcat/KM [mM/s]
1	Ki Value [mM]
28	KM Value [mM]
11	Localization
6	Metals/Ions
10	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
198	Organism
5	PDB ID
9	pH Optimum
3	pH Range
8	Posttranslational Modification
17	Protein Variants
7	Purification (Commentary)
11	Reaction
2	Reaction Type
51	Reference
88	Source Tissue
3	Specific Activity [micromol/min/mg]
3	Storage Stability
116	Substrates and Products (Substrate)
8	Subunits
70	Synonyms
6	Temperature Optimum [°C]
21	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 3.4.21.118 - kallikrein 8

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

3.45

benzyloxycarbonyl-Gly-Gly-Arg-7-amido-4-methylcoumarin

Homo sapiens

-

in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C

717863

29.02

Pro-Phe-Arg-7-amido-4-methylcoumarin

Homo sapiens

-

in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C

717863

31.2

tert-butyloxycarbonyl-Gln-Ala-Arg-7-amido-4-methylcoumarin

Homo sapiens

-

in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C

717863

15.1

tert-butyloxycarbonyl-Gln-Arg-Arg-7-amido-4-methylcoumarin

Homo sapiens

-

in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C

717863

3.85

tert-butyloxycarbonyl-Gln-Gly-Arg-7-amido-4-methylcoumarin

Homo sapiens

-

in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C

717863

13.91

tert-butyloxycarbonyl-Leu-Arg-Arg-7-amido-4-methylcoumarin

Homo sapiens

-

in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C

717863

11.12

tert-butyloxycarbonyl-Leu-Lys-Arg-7-amido-4-methylcoumarin

Homo sapiens

-

in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C

717863

11.96

tert-butyloxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin

Homo sapiens

-

in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C

717863

10.93

tert-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin

Homo sapiens

-

in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C

717863

283.4

tert-butyloxycarbonyl-Val-Pro-Arg-7-amido-4-methylcoumarin

Homo sapiens

-

in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C

717863

3.05

tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin

Homo sapiens

-

in 100 mM sodium phosphate, 0.01% (v/v) Tween 20, pH 8.5, at 37°C

717863