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3.4.11.1: leucyl aminopeptidase

This is an abbreviated version!
For detailed information about leucyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.1

Reaction

release of an N-terminal amino acid, Xaa-/-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolysed, but rates on arylamides are exceedingly low =

Synonyms

A-LAP, acidic M17 leucine aminopeptidase, AcLAP, adipocyte-derived leucine aminopeptidase, Aminopeptidase, aminopeptidase A, Aminopeptidase A/I, aminopeptidase I, aminopeptidase II, Aminopeptidase III, aminopeptidase LAP2, aminopeptidase N, AP 28, AP 56, APDkam589, APN, b/LAP, bovine lens/leucine aminopeptidase, BSAP, cathepsin III, CsLAP1, CsLAP2, cysteinyl-glycine hydrolysing activity, cysteinylglycine-hydrolysing activity, cytosol aminopeptidase, DR57, EC 3.4.1.1, Eg-LAP, endoplasmic reticulum aminopeptidase, ER-aminopeptidase-1, ERAP, ERAP1, ERAP2, FgLAP, FrvX, FTBL protein, FTBL proteins, HSA, L-leucine aminopeptidase, la, LAP, LAP yspII, LAP-A, LAP-N, LAP1, LAP2, lap3, LapA, LAPc, LeuAP, leucinamide aminopeptidase, leucinaminopeptidase, leucine amino peptidase, leucine aminopeptidase, leucine aminopeptidase 1, leucine aminopeptidase 2, leucine aminopeptidase 3, leucine aminopeptidase A, leucine aminopeptidase LAP-N, leucine aminopeptidase N, leucine aminopeptidase,, leucine aminopeptidase-A, Leucyl aminopeptidase, leucyl aminopeptidase (animal), leucyl aminopeptidase (plant), leucyl aminopeptidase yspII, leucyl peptidase, leucylaminopeptidase, leucylpeptidase, LmLAP-A, M17 family leucyl aminopeptidase metalloprotease, M17 LAP, M17 leucine amino peptidase, M17 leucine aminopeptidase, M17 leucyl aminopeptidase, M42 aminopeptidase, major leucyl aminopeptidase, More, PA2939, PaAP, PepA, PepA peptidase A, PepB, peptidase B, peptidase II, peptidase S, pepZ, PfLAP, PH1527, PhTET2, PILS-AP, PILSAP, Placental leucine aminopeptidase, PLAP, proline aminopeptidase, Prolyl aminopeptidase, proteins, specific or class, FTBL, PtLAP, puromycin insensitive leucyl-specific aminopeptidase, puromycin-insensitive leucine specific aminopeptidase, puromycin-insensitive leucyl-specific aminopeptidase, PVX_118180, rLAP, rMHJ_0461, S-Lap1, S-Lap2, S-Lap3, S-Lap4, S-Lap5, S-Lap6, S-Lap7, S-Lap8, SmLAP1, SmLAP2, Smp_03000, Smp_083870, sperm-leucylaminopeptidase, TbLAP-A, TbLAP1, TcLAP-A, TM0042, TpLAP, XoLAP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.1 leucyl aminopeptidase

Specific Activity

Specific Activity on EC 3.4.11.1 - leucyl aminopeptidase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0007
-
purified enzyme, substrate leukotriene D4
0.012
-
crude enzyme extract, day 24 of development
0.021
-
cytosolic fraction, substrate bimane-S-cysteinylglycine
0.044
-
kidney enzyme, substrate is N-(6-methoxy-2-methylpyridin-3-yl)-(S)-2-amino-4-methylpentanamide
0.18
-
purified enzyme
0.184
-
cytosolic fraction, substrate cysteinylglycine
0.192
-
purified recombinant enzyme
0.75
-
-
0.958
-
substrate L-leucine-4-methylcoumaryl-7-amide, pH 7.0, 37°C
1
mutant K310V, substrate Asp-Leu
1.5
-
leucyl-p-nitroanilide assay
10.9
purified enzyme
11
wild-type enzyme, substrate Ile-Leu and Val-Leu
11.4
mutant enzyme N345L, using Leu-p-nitroanilide as substrate, at pH 8.0
112.3
-
purified recombinant wild-type enzyme, substrate L-Leu-L-Arg
126
wild-type enzyme, substrate Asn-Leu
128
wild-type enzyme, substrate Cys-Leu
129 - 223
purified recombinant wild-type enzyme, substrate Leu-Leu
130.4
-
purified recombinant enzyme, substrate Leu-Gly
131.3
-
purified recombinant wild-type enzyme, substrate L-Phe-L-Leu
132.5
purified native enzyme, pH 8.5, 50°C, substrate Leu-4-nitroanilide
137
mutant R402W, substrate Leu-Leu
139
-
purified recombinant enzyme, substrate Arg-Gly
14
-
purified enzyme, substrate cysteinyl-bis-glycine
141.6
-
purified recombinant wild-type enzyme, substrate L-Leu-L-Asn
142
-
L-leucine-4-nitroanilide, pH 8.5, 50°C, 50% activity in the presence of 1 M NaCl
150.4
-
purified recombinant wild-type enzyme, substrate L-Leu-L-Ser
150.9
-
purified recombinant wild-type enzyme, substrate L-His-L-Leu
153.4
-
purified recombinant wild-type enzyme, substrate L-Pro-L-Leu
155.4
-
periplasm, cleavage of leucyl-hydrazide
16.5
pH 7.5, 80°C
164
wild-type enzyme, substrate Met-Leu
170.3
-
purified enzyme, substrate Leu-Gly
18
wild-type enzyme, substrate Thr-Leu and Ala-Leu
18.36
-
cytosol, cleavage of leucyl-hydrazide
19
-
purified enzyme, substrate Arg-Gly-Ser
196.7
-
purified enzyme, substrate Arg-Gly-Ser
200.8
-
purified recombinant wild-type enzyme, substrate L-Leu-L-Tyr
202
-
L-leucine-4-nitroanilide, pH 8.5, 60°C
21
-
purified enzyme, substrate Arg-Gly-Gly
214.3
-
purified recombinant wild-type enzyme, substrate L-Trp-L-Leu
221
-
Leu-Arg-Pro-Gly, pH 8.5, 50°C
23.7
-
purified enzyme, substrate Arg-Gly-Leu or Arg-Gly-Phe
239
purified recombinant wild-type enzyme, substrate Asp-Leu
240.48
purified recombinant enzyme, pH 8.5, 50°C, substrate Leu-4-nitroanilide
241.6
-
purified recombinant enzyme, substrate Leu-Gly-Gly
25
wild-type enzyme, substrate Trp-Leu
260
-
leucylamide assay
261.3
-
purified recombinant wild-type enzyme, substrate L-Thr-L-Leu
262.3
-
Leu-Gly-Arg-Ser-Gly-Gly-Asp-Ile-Ile-Lys-Lys-Met-Gln-Thr-Leu, pH 8.5, 50°C
268.1
-
1 mM leucyl-hydrazide, 0.05 M Tris/HCl buffer, pH 7.5
28.8
mutant enzyme N345Q, using Leu-p-nitroanilide as substrate, at pH 8.0
281.6
-
purified recombinant wild-type enzyme, substrate L-Val-L-Leu
3.9
-
L-leucine-4-nitroanilide, pH not specified in the publication, temperature not specified in the publication
300.1
-
purified enzyme, substrate Arg-Gly-Gly
310
mutant K310V, substrate Leu-Leu
318
-
purified enzyme, substrate Leu-Gly
32
wild-type enzyme, substrate Tyr-Leu
320.6
-
purified recombinant wild-type enzyme, substrate L-Ala-L-Leu
325.4
-
purified recombinant wild-type enzyme, substrate L-Leu-L-Met
345.3
-
purified recombinant wild-type enzyme, substrate L-Met-L-Leu
355.1
-
purified enzyme, substrate Arg-Gly-Phe
39
wild-type enzyme, substrate Phe-Leu
39.9
-
purified recombinant enzyme, substrate Arg-Gly-Asp
396.3
-
purified enzyme, substrate Arg-Gly-Leu
3977
-
after 4850.5fold purification, at 37°C
4.1
pH 7.5, 50°C, substrate: L-Leu-4-nitroanilide
4.3
-
purified enzyme, substrate Arg-Gly-Arg
4.54
-
substrate Leu-Gly-Gly
408
wild-type enzyme, substrate Glu-Leu
419.3
-
purified recombinant wild-type enzyme, substrate L-Leu-L-Leu
440.9
-
purified recombinant wild-type enzyme, substrate L-Leu-L-Phe
443.1
-
purified enzyme, substrate Arg-Gly
45.7
-
purified recombinant wild-type enzyme, substrate L-Tyr-L-Leu
47.7
-
purified recombinant enzyme, substrate Arg-Gly-Ser
49
wild-type enzyme, substrate Gln-Leu
5.1
-
kidney enzyme, substrate is L-leucine-4-nitroanilide
52
-
purified enzyme, substrate S-nitrosocysteinylglycine
53.2
-
purified recombinant enzyme, substrate Arg-Gly-Phe
53.5
-
purified enzyme, substrate Leu-Gly-Gly
550
wild-type enzyme, substrate Asp-Leu
57.1
-
purified enzyme, substrate Arg-Gly
58
-
substrate L-Leu-amide
6.5
-
kidney enzyme, substrate is N-(6-methoxypyridin-3-yl)-(S)-2-amino-4-methylpentanamide
6.64
-
4-[(E)-2-[4-cyano-5-(dicyanomethylidene)-2,2-dimethyl-2,5-dihydrofuran-3-yl]ethenyl]phenyl L-leucinate, pH 7.4, 25°C
604.7
-
purified enzyme, substrate Leu-Gly-Gly
63
mutant R402W, substrate Asp-Leu
68.7
-
purified enzyme, substrate Arg-Gly-Arg
69.3
-
purified enzyme, substrate Arg-Gly-Asp
7.7
-
N-(6-methoxy-2-methylpyridin-3-yl),(S)-2-amino-4-methylpentanamide, pH not specified in the publication, temperature not specified in the publication
70.9
-
purified recombinant enzyme, substrate Arg-Gly-Leu
77.5
-
purified recombinant enzyme, substrate Arg-Gly-Gly
790.5
-
purified enzyme, substrate Arg-Gly-Asp
8.4
-
kidney enzyme, substrate is (S)-2-amino-N-(6-(dimethylamino)pyridin-3-yl)-4-methylpentanamide
9.5
-
purified enzyme, substrate cysteinylglycine
9.6
-
kidney enzyme, substrate is L-leucyl-4-methylcoumaryl 7-amide
9.8
-
purified recombinant wild-type enzyme, substrate L-Leu-L-Asp
additional information