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3.4.11.1: leucyl aminopeptidase

This is an abbreviated version!
For detailed information about leucyl aminopeptidase, go to the full flat file.

Word Map on EC 3.4.11.1

Reaction

release of an N-terminal amino acid, Xaa-/-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolysed, but rates on arylamides are exceedingly low =

Synonyms

A-LAP, acidic M17 leucine aminopeptidase, AcLAP, adipocyte-derived leucine aminopeptidase, Aminopeptidase, aminopeptidase A, Aminopeptidase A/I, aminopeptidase I, aminopeptidase II, Aminopeptidase III, aminopeptidase LAP2, aminopeptidase N, AP 28, AP 56, APDkam589, APN, b/LAP, bovine lens/leucine aminopeptidase, BSAP, cathepsin III, CsLAP1, CsLAP2, cysteinyl-glycine hydrolysing activity, cysteinylglycine-hydrolysing activity, cytosol aminopeptidase, DR57, EC 3.4.1.1, Eg-LAP, endoplasmic reticulum aminopeptidase, ER-aminopeptidase-1, ERAP, ERAP1, ERAP2, FgLAP, FrvX, FTBL protein, FTBL proteins, HSA, L-leucine aminopeptidase, la, LAP, LAP yspII, LAP-A, LAP-N, LAP1, LAP2, lap3, LapA, LAPc, LeuAP, leucinamide aminopeptidase, leucinaminopeptidase, leucine amino peptidase, leucine aminopeptidase, leucine aminopeptidase 1, leucine aminopeptidase 2, leucine aminopeptidase 3, leucine aminopeptidase A, leucine aminopeptidase LAP-N, leucine aminopeptidase N, leucine aminopeptidase,, leucine aminopeptidase-A, Leucyl aminopeptidase, leucyl aminopeptidase (animal), leucyl aminopeptidase (plant), leucyl aminopeptidase yspII, leucyl peptidase, leucylaminopeptidase, leucylpeptidase, LmLAP-A, M17 family leucyl aminopeptidase metalloprotease, M17 LAP, M17 leucine amino peptidase, M17 leucine aminopeptidase, M17 leucyl aminopeptidase, M42 aminopeptidase, major leucyl aminopeptidase, More, PA2939, PaAP, PepA, PepA peptidase A, PepB, peptidase B, peptidase II, peptidase S, pepZ, PfLAP, PH1527, PhTET2, PILS-AP, PILSAP, Placental leucine aminopeptidase, PLAP, proline aminopeptidase, Prolyl aminopeptidase, proteins, specific or class, FTBL, PtLAP, puromycin insensitive leucyl-specific aminopeptidase, puromycin-insensitive leucine specific aminopeptidase, puromycin-insensitive leucyl-specific aminopeptidase, PVX_118180, rLAP, rMHJ_0461, S-Lap1, S-Lap2, S-Lap3, S-Lap4, S-Lap5, S-Lap6, S-Lap7, S-Lap8, SmLAP1, SmLAP2, Smp_03000, Smp_083870, sperm-leucylaminopeptidase, TbLAP-A, TbLAP1, TcLAP-A, TM0042, TpLAP, XoLAP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.11 Aminopeptidases
                3.4.11.1 leucyl aminopeptidase

IC50 Value

IC50 Value on EC 3.4.11.1 - leucyl aminopeptidase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.18
1,10-phenanthroline
Morimus funereus
-
-
1
2-amino-1,4-dihydro-2-isoquinolin-3-one
Bos taurus
-
-
0.12
3-amino-2-tetralone
Bos taurus
-
-
0.1
4-amino-3-(L-arginylamino)benzoic acid
Homo sapiens
pH and temperature not specified in the publication
0.0032 - 0.1
4-amino-3-(L-tyrosylamino)benzoic acid
0.011 - 0.013
benzyl N-(3-amino-4-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl)-L-tryptophanate
0.1
benzyl N-(3-amino-4-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl)-L-valinate
Homo sapiens
pH and temperature not specified in the publication
0.0239
benzyl N-(4-amino-3-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl)-L-tryptophanate
Homo sapiens
pH and temperature not specified in the publication
0.0089 - 0.021
benzyl N-[3-amino-4-(L-leucylamino)benzoyl]-L-tryptophanate
0.000709 - 0.0025
benzyl N-[3-amino-4-(L-norleucylamino)benzoyl]-L-tryptophanate
0.0062 - 0.1
benzyl N-[3-amino-4-(L-norleucylamino)benzoyl]-L-valinate
0.07
benzyl N-[3-amino-4-([(2S)-2-amino-4-[4-(benzyloxy)phenyl]butanoyl]amino)benzoyl]-L-tryptophanate
Homo sapiens
pH and temperature not specified in the publication
0.0011 - 0.02
benzyl N-[3-amino-4-[(O-benzyl-L-tyrosyl)amino]benzoyl]-L-tryptophanate
0.1
benzyl N-[4-amino-3-(D-norleucylamino)benzoyl]-L-valinate
Homo sapiens
pH and temperature not specified in the publication
0.00098 - 0.0016
benzyl N-[4-amino-3-(L-norleucylamino)benzoyl]-L-tryptophanate
0.0098 - 0.04
benzyl N-[4-amino-3-(L-tyrosylamino)benzoyl]-L-tryptophanate
0.05
benzyl N-[4-amino-3-(L-tyrosylamino)benzoyl]-L-valinate
Homo sapiens
pH and temperature not specified in the publication
0.1
benzyl N-[4-amino-3-[(O-benzyl-L-tyrosyl)amino]benzoyl]-L-tryptophanate
Homo sapiens
pH and temperature not specified in the publication
0.0000005 - 0.025
bestatin
0.0205
bestatin methyl ester
Plasmodium falciparum
inhibitory activity against recombinant enzyme
0.47
cysteine
Morimus funereus
-
-
0.0025
methyl 3-amino-4-(L-arginylamino)benzoate
Homo sapiens
pH and temperature not specified in the publication
0.1
methyl 3-amino-4-(L-leucylamino)benzoate
Homo sapiens
pH and temperature not specified in the publication
0.0011
methyl 3-amino-4-(L-norleucylamino)benzoate
Homo sapiens
pH and temperature not specified in the publication
0.058
methyl 3-amino-4-(L-tyrosylamino)benzoate
Homo sapiens
pH and temperature not specified in the publication
0.058 - 0.1
methyl 3-amino-4-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoate
0.0037
methyl 4-amino-3-(L-arginylamino)benzoate
Homo sapiens
pH and temperature not specified in the publication
0.0098 - 0.1
methyl 4-amino-3-(L-norleucylamino)benzoate
0.1
methyl 4-amino-3-(L-tyrosylamino)benzoate
Homo sapiens
pH and temperature not specified in the publication
0.1
methyl 4-amino-3-[[(2S)-2-amino-4-(4-hydroxyphenyl)butanoyl]amino]benzoate
Homo sapiens
pH and temperature not specified in the publication
0.1
methyl N-(3,4-diaminobenzoyl)-L-tyrosinate
Homo sapiens
pH and temperature not specified in the publication
0.0055 - 0.0094
methyl N-(3-amino-4-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl)-L-tyrosinate
0.0077 - 0.1
methyl N-(4-amino-3-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl)-L-tyrosinate
0.0014 - 0.0026
methyl N-[3-amino-4-(L-arginylamino)benzoyl]-L-tyrosinate
0.000755 - 0.1
methyl N-[3-amino-4-(L-norleucylamino)benzoyl]-L-tyrosinate
0.015 - 0.016
methyl N-[3-amino-4-(L-tyrosylamino)benzoyl]-L-tyrosinate
0.016
methyl N-[3-amino-4-[(O-benzyl-L-tyrosyl)amino]benzoyl]-L-tyrosinate
Homo sapiens
pH and temperature not specified in the publication
0.0064 - 0.1
methyl N-[4-amino-3-(D-norleucylamino)benzoyl]-D-tyrosinate
0.000518 - 0.0096
methyl N-[4-amino-3-(L-arginylamino)benzoyl]-D-tyrosinate
0.039 - 0.1
methyl N-[4-amino-3-(L-tyrosylamino)benzoyl]-L-threoninate
0.033 - 0.11
methyl N-[4-amino-3-(L-tyrosylamino)benzoyl]-L-tyrosinate
0.035
methyl N2-(3,4-diaminobenzoyl)-L-argininate
Homo sapiens
pH and temperature not specified in the publication
0.1
methyl N2-(3,4-diaminobenzoyl)-L-lysinate
Homo sapiens
pH and temperature not specified in the publication
0.011 - 0.012
methyl N2-(3-amino-4-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl)-L-argininate
0.0048 - 0.1
methyl N2-(4-amino-3-[[(2S)-2-amino-4-(4-hydroxyphenyl)butanoyl]amino]benzoyl)-L-lysinate
0.002 - 0.0249
methyl N2-(4-amino-3-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl)-L-lysinate
0.011
methyl N2-[3-amino-4-(L-arginylamino)benzoyl]-L-lysinate
Homo sapiens
pH and temperature not specified in the publication
0.03
methyl N2-[3-amino-4-(L-norleucylamino)benzoyl]-L-lysinate
Homo sapiens
pH and temperature not specified in the publication
0.1
methyl N2-[3-amino-4-(L-tyrosylamino)benzoyl]-L-lysinate
Homo sapiens
pH and temperature not specified in the publication
0.017 - 0.042
methyl N2-[4-amino-3-(L-arginylamino)benzoyl]-L-lysinate
0.052
methyl N2-[4-amino-3-(L-leucylamino)benzoyl]-L-lysinate
Homo sapiens
pH and temperature not specified in the publication
0.0025 - 0.0107
methyl N2-[4-amino-3-(L-norleucylamino)benzoyl]-D-argininate
0.0083 - 0.018
methyl N2-[4-amino-3-(L-norleucylamino)benzoyl]-L-lysinate
0.013 - 0.1
methyl N2-[4-amino-3-([(2S)-2-amino-4-[4-(benzyloxy)phenyl]butanoyl]amino)benzoyl]-L-lysinate
0.0019 - 0.1
N-(3,4-diaminobenzoyl)-L-tryptophan
0.008 - 0.0094
N-(3-amino-4-[[(2S)-2-amino-4-(4-hydroxyphenyl)butanoyl]amino]benzoyl)-L-tryptophan
0.1
N-(3-amino-4-[[(2S)-2-amino-4-phenylbutanoyl]amino]benzoyl)-L-valine
Homo sapiens
pH and temperature not specified in the publication
0.038 - 0.1
N-(4-amino-3-[[(2R)-2-amino-4-(4-hydroxyphenyl)butanoyl]amino]benzoyl)-L-tryptophan
0.0011 - 0.0038
N-[3-amino-4-(L-arginylamino)benzoyl]-L-tryptophan
0.000237 - 0.0028
N-[3-amino-4-(L-norleucylamino)benzoyl]-L-tryptophan
0.038
N-[3-amino-4-(L-norleucylamino)benzoyl]-L-valine
Homo sapiens
pH and temperature not specified in the publication
0.0048 - 0.019
N-[3-amino-4-(L-tyrosylamino)benzoyl]-L-tryptophan
0.1
N-[4-amino-3-(D-norleucylamino)benzoyl]-L-valine
Homo sapiens
pH and temperature not specified in the publication
0.000589 - 0.0012
N-[4-amino-3-(L-arginylamino)benzoyl]-L-tryptophan
0.005
N-[4-amino-3-(L-arginylamino)benzoyl]-L-valine
Homo sapiens
pH and temperature not specified in the publication
0.0036 - 0.0038
N-[4-amino-3-(L-norleucylamino)benzoyl]-L-tryptophan
0.012 - 0.1
N-[4-amino-3-(L-tyrosylamino)benzoyl]-L-tryptophan
0.1
N-[4-amino-3-(L-tyrosylamino)benzoyl]-L-valine
Homo sapiens
pH and temperature not specified in the publication
0.0021 - 0.0068
N2-[4-amino-3-(L-leucylamino)benzoyl]-L-lysine
0.0026
N2-[4-amino-3-(L-phenylalanylamino)benzoyl]-L-lysine
Homo sapiens
pH and temperature not specified in the publication
0.0045
N2-[4-amino-3-(L-tyrosylamino)benzoyl]-L-lysine
Homo sapiens
pH and temperature not specified in the publication
0.008
nitrobestatin
Plasmodium falciparum
inhibitory activity against recombinant enzyme
0.02
purpurin
Danio rerio
-
pH 7.4, 37°C