1.1.1.B4: (R)-specific secondary alcohol dehydrogenase (NADH)

This is an abbreviated version, for detailed information about (R)-specific secondary alcohol dehydrogenase (NADH), go to the full flat file.

Reaction

(R)-R-CHOH-R'
+
NAD+
=
R-CO-R'
+
NADH
+
H+

Synonyms

(R)-epinephrine dehydrogenase, ADH, ADH1, ADH2, ADHTt, carbonyl reductase, carbonyl reductase (NADH, specific for (S)-configuration of alcohol), CHY1186, CpCR, mLDH, More, SADH, SDR, secondary alcohol dehydrogenase, short-chain NAD(H)-dependent alcohol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B4 (R)-specific secondary alcohol dehydrogenase (NADH)

Inhibitors

Inhibitors on EC 1.1.1.B4 - (R)-specific secondary alcohol dehydrogenase (NADH)

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-butyl-3-methylimidazolium tetrafluoroborate
-
65% inhibition at 2 mM
8-hydroxyquinoline
-
1 mM, 55% residual activity
Ag+
-
complete inhibition
alpha,alpha'-dipyridyl
-
1 71, 43% residual activity
Ca2+
-
10% inhibition at 1 mM and 30% at 100 mM
CaCl2
-
1 mM, 21% residual activity
CoCl2
-
1 mM, 57% residual activity
CuSO4
-
1 mM, complete loss of activity
Fe3+
-
0.5 mM, 68% of initial activity
FeCl2
-
1 mM, 81% residual activity
FeCl3
-
1 mM, 65% residual activity
FeSO4
-
1 mM, complete loss of activity
iodoacetate
-
5% inhibition at 1 mM
Mg2+
-
33% inhibition at 100 mM
MgSO4
-
1 mM, 94% residual activity
MnSO4
-
1 mM, 69% residual activity
NiCl2
-
1 mM, 96% residual activity
o-phenanthroline
-
1 mM, 43% residual activity
p-chloromercuribenzoate
-
1 mM, 4% residual activity
Zn2+
-
inhibits at 1 mM
ZnCl2
-
1 mM, 73% residual activity
additional information
-
no effects by 5 mM 2-mercaptoethanol
-