1.1.1.B4: (R)-specific secondary alcohol dehydrogenase

This is an abbreviated version, for detailed information about (R)-specific secondary alcohol dehydrogenase, go to the full flat file.

Reaction

(R)-R-CHOH-R'
+
NAD+
=
R-CO-R'
+
NADH
+
H+

Synonyms

ADH, ADH1, ADH2, ADHTt, carbonyl reductase (NADH, specific for (S)-configuration of alcohol), CHY1186, More, SDR, short-chain NAD(H)-dependent alcohol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B4 (R)-specific secondary alcohol dehydrogenase

KM Value

KM Value on EC 1.1.1.B4 - (R)-specific secondary alcohol dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5.4
(R)-1,3-butandiol
-
pH 8.5, 30°C
0.045 - 37.4
(R)-2-butanol
0.22 - 11.7
(R)-2-pentanol
52
(S)-1,3-butandiol
-
pH 8.5, 30°C
0.35
(S)-2-butanol
-
pH 8.5, 30°C
10
1-butanol
-
pH 8.5, 30°C
4
1-propanol
-
pH 8.5, 30°C
11.2
2,2,2-trifluoroacetophenone
-
pH 6.0, 65°C, recombinant enzyme, reduction reaction
0.065
2-butanol
-
pH 8.5, 30°C
0.04
2-butanone
-
pH 6.0, 30°C
0.84
2-Pentanol
-
pH 8.5, 30°C
0.075 - 0.11
2-propanol
0.76
3-Pentanol
-
pH 8.5, 30°C
0.065
acetone
-
pH 6.0, 30°C
6.5
ethanol
-
pH 8.5, 30°C
5.3
ethyl 2-oxopropanoate
pH 6.5, 50°C
-
1
ethylbenzoylformate
-
pH 6.0, 65°C, recombinant enzyme, reduction reaction
0.15 - 0.525
NAD+
0.01 - 0.13
NADH
0.017 - 0.028
NADPH
additional information
additional information
-
kinetics and substrate specificity, overview
-