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(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
(2S)-2-aceto-2-hydroxybutyrate + NADPH + H+
(R)-2,3-dihydroxy-3-methylvalerate + NADP+
(2S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
(2S)-2-acetolactate + NADPH
(2R)-2,3-dihydroxyisovalerate + NADP+
(2S)-2-acetolactate + NADPH + H+
(2R)-2,3-dihydroxyisovalerate + NADP+
(2S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
(2S)-2-acetolactate + NADPH + H+
3-hydroxy-3-methyl-2-oxobutyrate + NADP+
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH
-
the enzyme is involved in biosynthesis of the branched chain amino acids valine and leucine, pathway overview
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-
?
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
(S)-2-acetolactate + NADH + H+
(2R)-2,3-dihydroxy-3-methylbutanoate + NAD+
(S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
(S)-2-acetolactate + NADH + H+
2,3-dihydroxy-3-methylbutanoate + NAD+
(S)-2-acetolactate + NADPH + H+
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
(S)-2-acetolactate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
2-aceto-2-hydroxybutyrate + NADP+
(2R,3R)-2,3-dihydroxy-3-methylvalerate + NADPH + H+
-
-
-
r
2-aceto-2-hydroxybutyrate + NADPH
2,3-dihydroxy-3-methylvalerate + NADP+
2-aceto-2-hydroxybutyrate + NADPH + H+
2,3-dihydroxy-3-methylvalerate + NADP+
-
-
-
-
r
2-aceto-2-hydroxybutyrate + NADPH + H+
? + NADP+
2-acetolactate + NADH + H+
2,3-dihydroxy-3-methylbutanoate + NAD+ + H+
2-acetolactate + NADP+
(2R)-2,3-dihydroxy-3-isovalerate + NADPH + H+
-
-
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+ + H+
-
the enzyme is the second of the valine pathway
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-
r
2-acetolactate + NADPH
2,3-dihydroxyisovalerate + NADP+
2-acetolactate + NADPH
3-hydroxy-3-methyl-2-oxobutyrate + NADP+
-
-
-
-
?
2-acetolactate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
2-acetolactate + NADPH + H+
3-hydroxy-3-methyl-2-oxobutyrate + NADP+
2-glutaryl lactic acid + NADPH
? + NADP+
2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-ethyl-butanoate + NADP+
-
-
-
-
?
2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-ethylbutanoate + NADP+
2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-methyl-butanoate + NADP+
-
-
-
-
?
2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
2-ketobutyrate + NADPH + H+
?
-
-
-
-
r
2-ketoisovalerate + NADPH + H+
?
-
-
-
-
r
2-ketopantoate + NADPH + H+
?
-
-
-
-
r
2-ketovalerate + NADPH + H+
?
-
-
-
-
r
2-methylacetoacetate + NADPH + H+
3-hydroxy-2-methylbutanoate + NADP+
2-tribromomethyl acetolactic acid + NADPH
? + NADP+
2-trichloromethyl acetolactic acid + NADPH
? + NADP+
-
-
-
?
2-trifluormethyl acetolactic acid + NADPH
? + NADP+
-
-
-
?
3-hydroxy-2-ketobutyrate + NADPH + H+
?
-
-
-
-
r
3-hydroxy-3-ethyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-ethyl-butanoate + NADP+
-
-
-
-
?
3-hydroxy-3-ethyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-ethylbutanoate + NADP+
3-hydroxy-3-methyl-2-ketobutyrate + NADP+
?
-
-
-
-
r
3-hydroxy-3-methyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-methyl-butanoate + NADP+
-
-
-
-
?
3-hydroxy-3-methyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
3-hydroxypyruvate + NADPH + H+
?
3-hydroxypyruvate + NADPH + H+
? + NADP+
acetolactate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
hydroxypyruvate + NADPH
glycerate + NADP+
-
-
-
?
hydroxypyruvate + NADPH + H+
2,3-dihydroxypropanoate + NADP+
hydroxypyruvate + NADPH + H+
glycerate + NADP+
NADP+ + 3-hydroxy-3-methyl-2-oxobutanoate
NADPH + acetolactate
-
-
-
?
NADPH + 2-aceto-2-hydroxybutyrate
NADP+ + ?
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
NADPH + 2-oxo-3-hydroxyisovalerate
NADP+ + alpha,beta-dihydroxyisovalerate
-
-
-
?
NADPH + alpha-aceto-alpha-hydroxybutyrate
NADP+ + ?
-
enzyme of isoleucine biosynthesis
-
-
?
pyrroline-5-carboxylate + NADPH + H+
? + NADP+
pyruvate + NADPH + H+
2-hydroxypropanoate + NADP+
pyruvate + NADPH + H+
?
-
-
-
-
r
additional information
?
-
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
-
-
-
-
r
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
-
-
-
-
r
(2S)-2-aceto-2-hydroxybutyrate + NADPH + H+
(R)-2,3-dihydroxy-3-methylvalerate + NADP+
-
-
-
?
(2S)-2-aceto-2-hydroxybutyrate + NADPH + H+
(R)-2,3-dihydroxy-3-methylvalerate + NADP+
-
-
-
?
(2S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
the enzyme prefers NADPH as a cofactor rather than NADH. kcat/Km for NADPH is 322fold higher than kcat/KM for NADH
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-
?
(2S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
the enzyme prefers NADPH as a cofactor rather than NADH. kcat/Km for NADPH is 322fold higher than kcat/KM for NADH
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-
?
(2S)-2-acetolactate + NADPH
(2R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
?
(2S)-2-acetolactate + NADPH
(2R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
?
(2S)-2-acetolactate + NADPH + H+
(2R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
?
(2S)-2-acetolactate + NADPH + H+
(2R)-2,3-dihydroxyisovalerate + NADP+
the reaction includes the initial deprotonation of the substrate C2 hydroxy group, bridged by the two Mg2+ ions, alkyl migration from the C2-alkoxide carbon atom to the C3-carbon
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-
?
(2S)-2-acetolactate + NADPH + H+
(2R)-2,3-dihydroxyisovalerate + NADP+
the reaction includes the initial deprotonation of the substrate C2 hydroxy group, bridged by the two Mg2+ ions, alkyl migration from the C2-alkoxide carbon atom to the C3-carbon
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-
?
(2S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
the enzyme prefers NADPH as a cofactor rather than NADH. kcat/Km for NADPH is 322fold higher than kcat/KM for NADH
-
-
?
(2S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
the enzyme prefers NADPH as a cofactor rather than NADH. kcat/Km for NADPH is 322fold higher than kcat/KM for NADH
-
-
?
(2S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
?
(2S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
?
(2S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
?
(2S)-2-acetolactate + NADPH + H+
3-hydroxy-3-methyl-2-oxobutyrate + NADP+
-
-
-
?
(2S)-2-acetolactate + NADPH + H+
3-hydroxy-3-methyl-2-oxobutyrate + NADP+
-
-
-
-
?
(2S)-2-acetolactate + NADPH + H+
3-hydroxy-3-methyl-2-oxobutyrate + NADP+
-
-
-
?
(2S)-2-acetolactate + NADPH + H+
3-hydroxy-3-methyl-2-oxobutyrate + NADP+
-
-
-
?
(2S)-2-acetolactate + NADPH + H+
3-hydroxy-3-methyl-2-oxobutyrate + NADP+
-
-
-
?
(2S)-2-acetolactate + NADPH + H+
3-hydroxy-3-methyl-2-oxobutyrate + NADP+
-
-
-
?
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
-
-
-
-
r
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
-
-
-
r
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
conformational changes in a plant ketol-acid reductoisomerase upon Mg2+ and NADPH binding, overview
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-
r
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
-
the enzyme performs a two-step reaction of an alkyl migration followed by an NADPH-dependent reduction rection
-
-
r
(S)-2-acetolactate + NADH + H+
(2R)-2,3-dihydroxy-3-methylbutanoate + NAD+
the enzyme can also use NADH for efficient catalysis. Higher activity by with NADPH as compared to NADH. kcat/Km ratio of NADH/NADPH is 0.051
-
-
?
(S)-2-acetolactate + NADH + H+
(2R)-2,3-dihydroxy-3-methylbutanoate + NAD+
the enzyme can also use NADH for efficient catalysis. Higher activity by with NADPH as compared to NADH. kcat/Km ratio of NADH/NADPH is 0.051
-
-
?
(S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
-
-
-
r
(S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
-
-
-
r
(S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
-
-
-
r
(S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
-
-
-
r
(S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
-
-
-
r
(S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
-
-
-
r
(S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
-
-
-
r
(S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
-
-
-
-
?
(S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
-
-
-
r
(S)-2-acetolactate + NADH + H+
2,3-dihydroxy-3-methylbutanoate + NAD+
-
-
-
?
(S)-2-acetolactate + NADH + H+
2,3-dihydroxy-3-methylbutanoate + NAD+
-
-
-
?
(S)-2-acetolactate + NADH + H+
2,3-dihydroxy-3-methylbutanoate + NAD+
-
-
-
?
(S)-2-acetolactate + NADPH + H+
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
?
(S)-2-acetolactate + NADPH + H+
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
-
?
(S)-2-acetolactate + NADPH + H+
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
?
(S)-2-acetolactate + NADPH + H+
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
?
(S)-2-acetolactate + NADPH + H+
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
the enzyme can also use NADH for efficient catalysis. Higher activity by with NADPH as compared to NADH. kcat/Km ratio of NADH/NADPH is 0.051
-
-
?
(S)-2-acetolactate + NADPH + H+
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
?
(S)-2-acetolactate + NADPH + H+
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
the enzyme can also use NADH for efficient catalysis. Higher activity by with NADPH as compared to NADH. kcat/Km ratio of NADH/NADPH is 0.051
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-
?
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
second enzyme in the branched-chain amino acid biosynthesis pathway
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-
?
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
second enzyme in the branched-chain amino acid biosynthesis pathway
-
-
?
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
-
?
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
-
-
-
r
(S)-2-acetolactate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
?
(S)-2-acetolactate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
?
(S)-2-acetolactate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
?
2-aceto-2-hydroxybutyrate + NADPH
2,3-dihydroxy-3-methylvalerate + NADP+
-
-
-
-
?
2-aceto-2-hydroxybutyrate + NADPH
2,3-dihydroxy-3-methylvalerate + NADP+
-
the enzyme is involved in biosynthesis of the branched chain amino acids valine and leucine, pathway overview
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-
?
2-aceto-2-hydroxybutyrate + NADPH + H+
? + NADP+
-
-
-
r
2-aceto-2-hydroxybutyrate + NADPH + H+
? + NADP+
-
-
-
r
2-acetolactate + NADH + H+
2,3-dihydroxy-3-methylbutanoate + NAD+ + H+
-
-
-
-
r
2-acetolactate + NADH + H+
2,3-dihydroxy-3-methylbutanoate + NAD+ + H+
-
-
-
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
second common reaction in the biosynthesis of the branched chain amino acids
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of valine synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
-
?
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
not reversible at pH 7.5, reversible at pH 9-10
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
-
enzyme of branched chain amino acid synthesis
-
r
2-acetolactate + NADPH
2,3-dihydroxyisovalerate + NADP+
-
-
-
-
?
2-acetolactate + NADPH
2,3-dihydroxyisovalerate + NADP+
-
the enzyme is involved in biosynthesis of the branched chain amino acid isoleucine, pathway overview
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-
?
2-acetolactate + NADPH
2,3-dihydroxyisovalerate + NADP+
-
-
-
?
2-acetolactate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
-
?
2-acetolactate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
-
r
2-acetolactate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
-
?
2-acetolactate + NADPH + H+
3-hydroxy-3-methyl-2-oxobutyrate + NADP+
-
-
-
?
2-acetolactate + NADPH + H+
3-hydroxy-3-methyl-2-oxobutyrate + NADP+
-
-
-
?
2-glutaryl lactic acid + NADPH
? + NADP+
-
-
-
?
2-glutaryl lactic acid + NADPH
? + NADP+
-
-
-
?
2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-ethylbutanoate + NADP+
-
-
-
-
?
2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-ethylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-ethylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-ethylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-ethylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-ethylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-ethylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-ethylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-ethylbutanoate + NADP+
-
-
-
-
?
2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-ethylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-ethylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-ethylbutanoate + NADP+
-
-
-
-
?
2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-ethylbutanoate + NADP+
-
-
-
-
?
2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
-
-
-
-
?
2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
-
-
-
-
?
2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
-
-
-
-
?
2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
-
-
-
-
?
2-methylacetoacetate + NADPH + H+
3-hydroxy-2-methylbutanoate + NADP+
-
-
-
-
?
2-methylacetoacetate + NADPH + H+
3-hydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-methylacetoacetate + NADPH + H+
3-hydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-methylacetoacetate + NADPH + H+
3-hydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-methylacetoacetate + NADPH + H+
3-hydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-methylacetoacetate + NADPH + H+
3-hydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-methylacetoacetate + NADPH + H+
3-hydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-methylacetoacetate + NADPH + H+
3-hydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-methylacetoacetate + NADPH + H+
3-hydroxy-2-methylbutanoate + NADP+
-
-
-
-
?
2-methylacetoacetate + NADPH + H+
3-hydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-methylacetoacetate + NADPH + H+
3-hydroxy-2-methylbutanoate + NADP+
-
-
-
?
2-methylacetoacetate + NADPH + H+
3-hydroxy-2-methylbutanoate + NADP+
-
-
-
-
?
2-methylacetoacetate + NADPH + H+
3-hydroxy-2-methylbutanoate + NADP+
-
-
-
-
?
2-tribromomethyl acetolactic acid + NADPH
? + NADP+
-
-
-
?
2-tribromomethyl acetolactic acid + NADPH
? + NADP+
-
-
-
?
3-hydroxy-3-ethyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-ethylbutanoate + NADP+
-
-
-
-
?
3-hydroxy-3-ethyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-ethylbutanoate + NADP+
-
-
-
?
3-hydroxy-3-ethyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-ethylbutanoate + NADP+
-
-
-
?
3-hydroxy-3-ethyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-ethylbutanoate + NADP+
-
-
-
?
3-hydroxy-3-ethyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-ethylbutanoate + NADP+
-
-
-
?
3-hydroxy-3-ethyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-ethylbutanoate + NADP+
-
-
-
?
3-hydroxy-3-ethyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-ethylbutanoate + NADP+
-
-
-
?
3-hydroxy-3-ethyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-ethylbutanoate + NADP+
-
-
-
?
3-hydroxy-3-ethyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-ethylbutanoate + NADP+
-
-
-
-
?
3-hydroxy-3-ethyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-ethylbutanoate + NADP+
-
-
-
?
3-hydroxy-3-ethyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-ethylbutanoate + NADP+
-
-
-
?
3-hydroxy-3-ethyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-ethylbutanoate + NADP+
-
-
-
-
?
3-hydroxy-3-ethyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-ethylbutanoate + NADP+
-
-
-
-
?
3-hydroxy-3-methyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
-
?
3-hydroxy-3-methyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
?
3-hydroxy-3-methyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
?
3-hydroxy-3-methyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
?
3-hydroxy-3-methyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
-
?
3-hydroxy-3-methyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
?
3-hydroxy-3-methyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
-
?
3-hydroxy-3-methyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
-
-
-
-
?
3-hydroxypyruvate + NADPH + H+
?
-
-
-
-
?
3-hydroxypyruvate + NADPH + H+
?
-
-
-
-
r
3-hydroxypyruvate + NADPH + H+
?
-
-
-
-
?
3-hydroxypyruvate + NADPH + H+
? + NADP+
-
-
-
r
3-hydroxypyruvate + NADPH + H+
? + NADP+
-
-
-
r
acetolactate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
-
-
-
r
acetolactate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
-
-
-
-
r
hydroxypyruvate + NADPH + H+
2,3-dihydroxypropanoate + NADP+
-
-
-
-
?
hydroxypyruvate + NADPH + H+
2,3-dihydroxypropanoate + NADP+
-
-
-
?
hydroxypyruvate + NADPH + H+
2,3-dihydroxypropanoate + NADP+
-
-
-
?
hydroxypyruvate + NADPH + H+
2,3-dihydroxypropanoate + NADP+
-
-
-
?
hydroxypyruvate + NADPH + H+
2,3-dihydroxypropanoate + NADP+
-
-
-
?
hydroxypyruvate + NADPH + H+
2,3-dihydroxypropanoate + NADP+
-
-
-
?
hydroxypyruvate + NADPH + H+
2,3-dihydroxypropanoate + NADP+
-
-
-
?
hydroxypyruvate + NADPH + H+
2,3-dihydroxypropanoate + NADP+
-
-
-
?
hydroxypyruvate + NADPH + H+
2,3-dihydroxypropanoate + NADP+
-
-
-
-
?
hydroxypyruvate + NADPH + H+
2,3-dihydroxypropanoate + NADP+
-
-
-
?
hydroxypyruvate + NADPH + H+
2,3-dihydroxypropanoate + NADP+
-
-
-
?
hydroxypyruvate + NADPH + H+
2,3-dihydroxypropanoate + NADP+
-
-
-
-
?
hydroxypyruvate + NADPH + H+
2,3-dihydroxypropanoate + NADP+
-
-
-
-
?
hydroxypyruvate + NADPH + H+
glycerate + NADP+
-
-
-
-
?
hydroxypyruvate + NADPH + H+
glycerate + NADP+
-
-
-
?
hydroxypyruvate + NADPH + H+
glycerate + NADP+
-
-
-
?
NADPH + 2-aceto-2-hydroxybutyrate
NADP+ + ?
-
activity is 6-10times greater than that for 2-acetolactate
-
-
?
NADPH + 2-aceto-2-hydroxybutyrate
NADP+ + ?
-
-
-
-
?
NADPH + 2-aceto-2-hydroxybutyrate
NADP+ + ?
-
-
-
-
?
NADPH + 2-aceto-2-hydroxybutyrate
NADP+ + ?
-
-
-
-
?
NADPH + 2-aceto-2-hydroxybutyrate
NADP+ + ?
-
-
-
-
?
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
-
-
?
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
-
-
-
?
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
-
-
-
r
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
-
-
-
?
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
-
-
-
?
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
-
-
-
?
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
-
-
-
?
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
-
-
-
?
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
not reversible at pH 7.5, reversible at pH 9-10
-
-
?, r
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
alpha-keto-beta-hydroxyisovalerate is not a free intermediate
-
-
?, r
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
ordered reaction with NADPH and the acetohydroxy acid adding in that order, and dihydroxy acid released before NADP+. 4 mol of NADPH bind per mol of enzyme
-
-
?
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
-
-
-
?
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
-
-
-
?
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
-
-
?
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
-
-
-
?
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
-
-
-
?
pyrroline-5-carboxylate + NADPH + H+
? + NADP+
-
-
-
-
?
pyrroline-5-carboxylate + NADPH + H+
? + NADP+
-
-
-
?
pyrroline-5-carboxylate + NADPH + H+
? + NADP+
-
-
-
?
pyrroline-5-carboxylate + NADPH + H+
? + NADP+
-
-
-
?
pyrroline-5-carboxylate + NADPH + H+
? + NADP+
-
-
-
-
?
pyrroline-5-carboxylate + NADPH + H+
? + NADP+
-
-
-
?
pyrroline-5-carboxylate + NADPH + H+
? + NADP+
-
-
-
-
?
pyrroline-5-carboxylate + NADPH + H+
? + NADP+
-
-
-
-
?
pyruvate + NADPH + H+
2-hydroxypropanoate + NADP+
-
-
-
-
?
pyruvate + NADPH + H+
2-hydroxypropanoate + NADP+
-
-
-
?
pyruvate + NADPH + H+
2-hydroxypropanoate + NADP+
-
-
-
?
pyruvate + NADPH + H+
2-hydroxypropanoate + NADP+
-
-
-
?
pyruvate + NADPH + H+
2-hydroxypropanoate + NADP+
-
-
-
-
?
pyruvate + NADPH + H+
2-hydroxypropanoate + NADP+
-
-
-
?
pyruvate + NADPH + H+
2-hydroxypropanoate + NADP+
-
-
-
-
?
pyruvate + NADPH + H+
2-hydroxypropanoate + NADP+
-
-
-
-
?
additional information
?
-
-
the enzyme is involved in biosynthesis of branched amino acids valine, isoleucine, and leucine, pathway overview
-
-
?
additional information
?
-
-
the enzyme catalyses the second reaction in the biosynthesis of the branched-chain amino acids
-
-
?
additional information
?
-
-
the enzyme is involved in the biosynthesis of the branched-chain amino acids
-
-
?
additional information
?
-
-
structure-biological activity relationship, overview
-
-
?
additional information
?
-
-
structure-biological activity relationship, overview
-
-
?
additional information
?
-
KARI catalyzes two reactions: alkyl migration and reduction. Structure-function relationship, effects of ligand binding, MG2+ and NADPH, on the enzyme conformation, overview
-
-
?
additional information
?
-
-
KARI catalyzes two reactions: alkyl migration and reduction. Structure-function relationship, effects of ligand binding, MG2+ and NADPH, on the enzyme conformation, overview
-
-
?
additional information
?
-
-
structure-activity relationship
-
-
?
additional information
?
-
-
enzyme expression is up-regulated in germinating cysts developing appressoria, which are important for interaction of pathogen and host plants tomato and potato
-
-
?
additional information
?
-
-
the enzyme is involved in biosynthesis of branched chain amino acids valine, isoleucine, and leucine, effects of KARI inhibition effects on other enzymes, such as alcohol dehydrogenase, EC 1.1.1.1, pyruvate dehydrogenase, EC 4.1.1.1, lactate dehydrogenase, EC 1.1.1.27, and alanine aminotransferase, EC 2.6.1.2, overview
-
-
?
additional information
?
-
-
the enzyme is involved in the biosynthesis of the branched-chain amino acids
-
-
?
additional information
?
-
-
the enzyme is involved in the biosynthesis of the branched-chain amino acids
-
-
?
additional information
?
-
-
the enzyme catalyzes the isomerization of 2-oxo-3-hydroxyisovalerate to 2-acetolactate
-
-
?
additional information
?
-
-
structure-biological activity relationship, overview
-
-
?