1.1.1.86: ketol-acid reductoisomerase (NADP+)

This is an abbreviated version, for detailed information about ketol-acid reductoisomerase (NADP+), go to the full flat file.

Reaction

(2R)-2,3-dihydroxy-3-methylbutanoate
+
NADP+
=
(2S)-2-hydroxy-2-methyl-3-oxobutanoate
+
NADPH
+
H+

Synonyms

2-hydroxy-3-keto acid reductoisomerase, acetohydroxy acid isomeroreductase, acetohydroxy acid reductoisomerase, acetohydroxy-acid isomeroreductase , acetohydroxy-acid reductoisomerase , acetohydroxyacid isomeroreductase, acetolactate reductoisomerase, AHAIR, AHIR, alpha-keto-beta-hydroxylacil reductoisomerase, alpha-keto-beta-hydroxylacyl reductoisomerase, class II ketol-acid reductoisomerase, dehydrogenase, dihydroxyisovalerate (isomerizing), dihydroxyisovalerate dehydrogenase (isomerizing), Icl1p, Ilv5p, ilvC, IlvC-PanE, IlvC1, IlvC2, isomerase, ketol acid reducto-, isomeroreductase, KARI, ketol-acid reductoisomerase, reductoisomerase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.86 ketol-acid reductoisomerase (NADP+)

Substrates Products

Substrates Products on EC 1.1.1.86 - ketol-acid reductoisomerase (NADP+)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(2S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
show the reaction diagram
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH
show the reaction diagram
-
the enzyme is involved in biosynthesis of the branched chain amino acids valine and leucine, pathway overview
-
-
?
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+
(S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
show the reaction diagram
(S)-2-acetolactate + NADH + H+
(R)-2,3-dihydroxyisovalerate + NAD+
show the reaction diagram
(S)-2-acetolactate + NADH + H+
2,3-dihydroxy-3-methylbutanoate + NAD+
show the reaction diagram
(S)-2-acetolactate + NADPH + H+
(R)-2,3-dihydroxyisovalerate + NADP+
show the reaction diagram
(S)-2-acetolactate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
show the reaction diagram
2-aceto-2-hydroxybutyrate + NADP+
(2R,3R)-2,3-dihydroxy-3-methylvalerate + NADPH + H+
show the reaction diagram
-
-
-
-
r
2-aceto-2-hydroxybutyrate + NADPH
2,3-dihydroxy-3-methylvalerate + NADP+
show the reaction diagram
2-aceto-2-hydroxybutyrate + NADPH + H+
? + NADP+
show the reaction diagram
2-acetolactate + NADP+
(2R)-2,3-dihydroxy-3-isovalerate + NADPH + H+
show the reaction diagram
-
-
-
-
r
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+
show the reaction diagram
2-acetolactate + NADPH
2,3-dihydroxy-3-methylbutanoate + NADP+ + H+
show the reaction diagram
-
the enzyme is the second of the valine pathway
-
-
r
2-acetolactate + NADPH
2,3-dihydroxyisovalerate + NADP+
show the reaction diagram
2-acetolactate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
show the reaction diagram
2-acetolactate + NADPH + H+
3-hydroxy-2-ketobutyrate + NADP+
show the reaction diagram
-
-
-
-
r
2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-ethyl-butanoate + NADP+
show the reaction diagram
-
-
-
-
?
2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-ethylbutanoate + NADP+
show the reaction diagram
2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-methyl-butanoate + NADP+
show the reaction diagram
-
-
-
-
?
2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
show the reaction diagram
2-ketobutyrate + NADPH + H+
?
show the reaction diagram
-
-
-
-
r
2-ketoisovalerate + NADPH + H+
?
show the reaction diagram
-
-
-
-
r
2-ketopantoate + NADPH + H+
?
show the reaction diagram
-
-
-
-
r
2-ketovalerate + NADPH + H+
?
show the reaction diagram
-
-
-
-
r
2-methylacetoacetate + NADPH + H+
3-hydroxy-2-methylbutanoate + NADP+
show the reaction diagram
2-methylacetoacetate + NADPH + H+
3-hydroxy-2-methylbutanoate+ NADP+
show the reaction diagram
-
-
-
-
?
3-hydroxy-3-ethyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-ethyl-butanoate + NADP+
show the reaction diagram
-
-
-
-
?
3-hydroxy-3-ethyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-ethylbutanoate + NADP+
show the reaction diagram
3-hydroxy-3-methyl-2-ketobutyrate + NADP+
?
show the reaction diagram
-
-
-
-
r
3-hydroxy-3-methyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-methyl-butanoate + NADP+
show the reaction diagram
-
-
-
-
?
3-hydroxy-3-methyl-2-oxobutanoate + NADPH + H+
2,3-dihydroxy-3-methylbutanoate + NADP+
show the reaction diagram
3-hydroxypyruvate + NADPH + H+
?
show the reaction diagram
3-hydroxypyruvate + NADPH + H+
? + NADP+
show the reaction diagram
acetolactate + NADPH + H+
2,3-dihydroxy-2-methylbutanoate + NADP+
show the reaction diagram
hydroxypyruvate + NADPH
glycerate + NADP+
show the reaction diagram
-
-
-
?
hydroxypyruvate + NADPH + H+
2,3-dihydroxypropanoate + NADP+
show the reaction diagram
hydroxypyruvate + NADPH + H+
2,3-dihydroxypropanoate+ NADP+
show the reaction diagram
-
-
-
-
?
NADP+ + 3-hydroxy-3-methyl-2-oxobutanoate
NADPH + acetolactate
show the reaction diagram
-
-
-
?
NADPH + 2-aceto-2-hydroxybutyrate
NADP+ + ?
show the reaction diagram
NADPH + 2-acetolactate
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
show the reaction diagram
NADPH + 2-oxo-3-hydroxyisovalerate
NADP+ + alpha,beta-dihydroxyisovalerate
show the reaction diagram
-
-
-
?
NADPH + alpha-aceto-alpha-hydroxybutyrate
NADP+ + ?
show the reaction diagram
-
enzyme of isoleucine biosynthesis
-
-
?
pyrroline-5-carboxylate + NADPH + H+
? + NADP+
show the reaction diagram
pyruvate + NADPH + H+
2-hydroxypropanoate + NADP+
show the reaction diagram
pyruvate + NADPH + H+
?
show the reaction diagram
-
-
-
-
r
additional information
?
-