1.1.1.86: ketol-acid reductoisomerase (NADP+)

This is an abbreviated version, for detailed information about ketol-acid reductoisomerase (NADP+), go to the full flat file.

Reaction

(2R)-2,3-dihydroxy-3-methylbutanoate
+
NADP+
=
(2S)-2-hydroxy-2-methyl-3-oxobutanoate
+
NADPH
+
H+

Synonyms

2-hydroxy-3-keto acid reductoisomerase, acetohydroxy acid isomeroreductase, acetohydroxy acid reductoisomerase, acetohydroxy-acid isomeroreductase , acetohydroxy-acid reductoisomerase , acetohydroxyacid isomeroreductase, acetolactate reductoisomerase, AHAIR, AHIR, alpha-keto-beta-hydroxylacil reductoisomerase, alpha-keto-beta-hydroxylacyl reductoisomerase, class II ketol-acid reductoisomerase, dehydrogenase, dihydroxyisovalerate (isomerizing), dihydroxyisovalerate dehydrogenase (isomerizing), Icl1p, Ilv5p, ilvC, IlvC-PanE, IlvC1, IlvC2, isomerase, ketol acid reducto-, isomeroreductase, KARI, ketol-acid reductoisomerase, reductoisomerase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.86 ketol-acid reductoisomerase (NADP+)

Turnover Number

Turnover Number on EC 1.1.1.86 - ketol-acid reductoisomerase (NADP+)

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.77 - 3.81
(S)-2-acetolactate
0.00417
2,3-Dihydroxy-3-methylbutanoate
Escherichia coli
-
pH 7.4, 25C
78.3
2-aceto-2-hydroxybutyrate
Salmonella enterica subsp. enterica serovar Typhimurium
-
30C
1.2 - 18.3
2-acetolactate
0.12 - 3.6
2-hydroxy-2-ethyl-3-oxobutanoate
0.24 - 3.6
2-Hydroxy-2-methyl-3-oxobutanoate
0.167
2-Ketobutyrate
Escherichia coli
-
pH 8.0, 37C
0.182
2-ketoisovalerate
Escherichia coli
-
pH 8.0, 37C
0.194
2-ketopantoate
Escherichia coli
-
pH 8.0, 37C
0.05
2-Ketovalerate
Escherichia coli
-
pH 8.0, 37C
0.4 - 2
2-Methylacetoacetate
0.594
3-hydroxy-2-ketobutyrate
Escherichia coli
-
pH 8.0, 37C
0.18 - 3.8
3-hydroxy-3-ethyl-2-oxobutanoate
-
3.511
3-hydroxy-3-methyl-2-ketobutyrate
Escherichia coli
-
pH 8.0, 37C
0.3 - 5.2
3-Hydroxy-3-methyl-2-oxobutanoate
4.5 - 26
3-hydroxypyruvate
0.5 - 2
Hydroxypyruvate
0.00183 - 0.3
NADH
0.00015 - 0.000667
NADP+
0.0000933 - 0.98
NADPH
0.021 - 8.6
pyruvate