1.1.1.86: ketol-acid reductoisomerase (NADP+)

This is an abbreviated version, for detailed information about ketol-acid reductoisomerase (NADP+), go to the full flat file.

Reaction

(2R)-2,3-dihydroxy-3-methylbutanoate
+
NADP+
=
(2S)-2-hydroxy-2-methyl-3-oxobutanoate
+
NADPH
+
H+

Synonyms

2-hydroxy-3-keto acid reductoisomerase, acetohydroxy acid isomeroreductase, acetohydroxy acid reductoisomerase, acetohydroxy-acid isomeroreductase , acetohydroxy-acid reductoisomerase , acetohydroxyacid isomeroreductase, acetolactate reductoisomerase, AHAIR, AHIR, alpha-keto-beta-hydroxylacil reductoisomerase, alpha-keto-beta-hydroxylacyl reductoisomerase, class II ketol-acid reductoisomerase, dehydrogenase, dihydroxyisovalerate (isomerizing), dihydroxyisovalerate dehydrogenase (isomerizing), Icl1p, Ilv5p, ilvC, IlvC-PanE, IlvC1, IlvC2, isomerase, ketol acid reducto-, isomeroreductase, KARI, ketol-acid reductoisomerase, reductoisomerase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.86 ketol-acid reductoisomerase (NADP+)

KCat KM Value

KCat KM Value on EC 1.1.1.86 - ketol-acid reductoisomerase (NADP+)

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4.6 - 34.1
(S)-2-acetolactate
101726
2.4 - 120
2-acetolactate
2257
0.012 - 11.67
2-hydroxy-2-ethyl-3-oxobutanoate
29384
0.02 - 7.14
2-Hydroxy-2-methyl-3-oxobutanoate
7990
0.01 - 0.06
2-Methylacetoacetate
43162
0.01 - 13.1
3-hydroxy-3-ethyl-2-oxobutanoate
213988
0.03 - 11.92
3-Hydroxy-3-methyl-2-oxobutanoate
29486
3.3 - 4.16
3-hydroxypyruvate
1370
0.02 - 0.06
Hydroxypyruvate
389
0.0046 - 9
NADH
8
0.01 - 54.5
NADPH
5
0.0024 - 0.0061
pyrroline-5-carboxylate
10887
0.001 - 0.008
pyruvate
31