BRENDA - Enzyme Database show
show all sequences of 1.1.1.86

The reductoisomerase of Neurospora crassa

Kiritani, K.; Narise, S.; Wagner, R.P.; J. Biol. Chem. 241, 2047-2051 (1966)
No PubMed abstract available

Data extracted from this reference:

General Stability
General Stability
Organism
unstable in absence of NADPH and Mg2+, very unstable in Tris buffer, 2-mercaptoethanol stabilizes
Neurospora crassa
Inhibitors
Inhibitors
Commentary
Organism
Structure
NADH
-
Neurospora crassa
NADP+
-
Neurospora crassa
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.16
-
2-aceto-2-hydroxybutyrate
pH 7.5, 25C
Neurospora crassa
0.32
-
2-acetolactate
pH 7.5, 25C
Neurospora crassa
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
optimum concentration 5 mM; required
Neurospora crassa
additional information
metal ions other than Mg2+ are inhibitory
Neurospora crassa
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2-acetolactate + NADPH
Neurospora crassa
enzyme of branched chain amino acid synthesis
2,3-dihydroxy-3-methylbutanoate + NADP+
-
Neurospora crassa
r
2-acetolactate + NADPH
Neurospora crassa
enzyme of valine synthesis
2,3-dihydroxy-3-methylbutanoate + NADP+
-
Neurospora crassa
r
NADPH + alpha-aceto-alpha-hydroxybutyrate
Neurospora crassa
enzyme of isoleucine biosynthesis
NADP+ + ?
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Neurospora crassa
-
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
lipoprotein
purified enzyme contains 39-46% lipid
Neurospora crassa
Purification (Commentary)
Commentary
Organism
-
Neurospora crassa
Specific Activity [micromol/min/mg]
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
18.5
-
-
Neurospora crassa
Storage Stability
Storage Stability
Organism
-10, in presence of NADPH, 5 d, 70-80% loss of activity
Neurospora crassa
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-acetolactate + NADPH
enzyme of branched chain amino acid synthesis
639171
Neurospora crassa
2,3-dihydroxy-3-methylbutanoate + NADP+
-
639171
Neurospora crassa
r
2-acetolactate + NADPH
enzyme of valine synthesis
639171
Neurospora crassa
2,3-dihydroxy-3-methylbutanoate + NADP+
-
639171
Neurospora crassa
r
NADPH + 2-aceto-2-hydroxybutyrate
activity is 6-10times greater than that for 2-acetolactate
639171
Neurospora crassa
NADP+ + ?
-
-
-
?
NADPH + 2-acetolactate
-
639171
Neurospora crassa
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
-
-
?
NADPH + alpha-aceto-alpha-hydroxybutyrate
enzyme of isoleucine biosynthesis
639171
Neurospora crassa
NADP+ + ?
-
-
-
?
Temperature Stability [C]
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
40
-
5 min, about 90% loss of activity at pH 6.2, about 55% loss of activity at pH 6.5, 35% loss of activity oH 7.0, 30% loss of activity at pH 7.5, about 85% loss of activity at pH 8.0, about 90% loss of activity at pH 8.5
Neurospora crassa
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
2-acetolactate as substrate; alpha-aceto-alpha-hydroxybutyrate
Neurospora crassa
pH Range
pH Minimum
pH Maximum
Commentary
Organism
6.6
8.8
pH 6.6: about 65% of maximal activity, pH 8.8: about 90% of maximal activity, reaction with 2-acetolactate, Tris buffer
Neurospora crassa
7
8.5
pH 7.0: about 60% of maximal activity, pH 8.5: about 65% of maximal activity
Neurospora crassa
pH Stability
pH Stability
pH Stability Maximum
Commentary
Organism
6.2
-
40C, 5 min, 90% loss of activity
Neurospora crassa
6.5
-
40C, 5 min, 55% loss of activity
Neurospora crassa
7
-
40C, 5 min, 35% loss of activity
Neurospora crassa
7.5
-
40C, 5 min, 30% loss of activity
Neurospora crassa
8
-
40C, 5 min, 85% loss of activity
Neurospora crassa
8.5
-
40C, 5 min, 90% loss of activity
Neurospora crassa
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
-
Neurospora crassa
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
-
Neurospora crassa
General Stability (protein specific)
General Stability
Organism
unstable in absence of NADPH and Mg2+, very unstable in Tris buffer, 2-mercaptoethanol stabilizes
Neurospora crassa
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
NADH
-
Neurospora crassa
NADP+
-
Neurospora crassa
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.16
-
2-aceto-2-hydroxybutyrate
pH 7.5, 25C
Neurospora crassa
0.32
-
2-acetolactate
pH 7.5, 25C
Neurospora crassa
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
optimum concentration 5 mM; required
Neurospora crassa
additional information
metal ions other than Mg2+ are inhibitory
Neurospora crassa
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2-acetolactate + NADPH
Neurospora crassa
enzyme of branched chain amino acid synthesis
2,3-dihydroxy-3-methylbutanoate + NADP+
-
Neurospora crassa
r
2-acetolactate + NADPH
Neurospora crassa
enzyme of valine synthesis
2,3-dihydroxy-3-methylbutanoate + NADP+
-
Neurospora crassa
r
NADPH + alpha-aceto-alpha-hydroxybutyrate
Neurospora crassa
enzyme of isoleucine biosynthesis
NADP+ + ?
-
-
?
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
lipoprotein
purified enzyme contains 39-46% lipid
Neurospora crassa
Purification (Commentary) (protein specific)
Commentary
Organism
-
Neurospora crassa
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [mol/min/mg]
Specific Activity Maximum [mol/min/mg]
Commentary
Organism
18.5
-
-
Neurospora crassa
Storage Stability (protein specific)
Storage Stability
Organism
-10, in presence of NADPH, 5 d, 70-80% loss of activity
Neurospora crassa
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-acetolactate + NADPH
enzyme of branched chain amino acid synthesis
639171
Neurospora crassa
2,3-dihydroxy-3-methylbutanoate + NADP+
-
639171
Neurospora crassa
r
2-acetolactate + NADPH
enzyme of valine synthesis
639171
Neurospora crassa
2,3-dihydroxy-3-methylbutanoate + NADP+
-
639171
Neurospora crassa
r
NADPH + 2-aceto-2-hydroxybutyrate
activity is 6-10times greater than that for 2-acetolactate
639171
Neurospora crassa
NADP+ + ?
-
-
-
?
NADPH + 2-acetolactate
-
639171
Neurospora crassa
NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
-
-
?
NADPH + alpha-aceto-alpha-hydroxybutyrate
enzyme of isoleucine biosynthesis
639171
Neurospora crassa
NADP+ + ?
-
-
-
?
Temperature Stability [C] (protein specific)
Temperature Stability Minimum [C]
Temperature Stability Maximum [C]
Commentary
Organism
40
-
5 min, about 90% loss of activity at pH 6.2, about 55% loss of activity at pH 6.5, 35% loss of activity oH 7.0, 30% loss of activity at pH 7.5, about 85% loss of activity at pH 8.0, about 90% loss of activity at pH 8.5
Neurospora crassa
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
-
2-acetolactate as substrate; alpha-aceto-alpha-hydroxybutyrate
Neurospora crassa
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
6.6
8.8
pH 6.6: about 65% of maximal activity, pH 8.8: about 90% of maximal activity, reaction with 2-acetolactate, Tris buffer
Neurospora crassa
7
8.5
pH 7.0: about 60% of maximal activity, pH 8.5: about 65% of maximal activity
Neurospora crassa
pH Stability (protein specific)
pH Stability
pH Stability Maximum
Commentary
Organism
6.2
-
40C, 5 min, 90% loss of activity
Neurospora crassa
6.5
-
40C, 5 min, 55% loss of activity
Neurospora crassa
7
-
40C, 5 min, 35% loss of activity
Neurospora crassa
7.5
-
40C, 5 min, 30% loss of activity
Neurospora crassa
8
-
40C, 5 min, 85% loss of activity
Neurospora crassa
8.5
-
40C, 5 min, 90% loss of activity
Neurospora crassa
Other publictions for EC 1.1.1.86
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738067
Tadrowski
Metal ions play an essential c ...
Escherichia coli, Oryza sativa
Chemistry
22
7427-7436
2016
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2
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2
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2
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2
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6
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4
2
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4
4
738219
Lv
Crystal structure of Mycobacte ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
FEBS J.
283
1184-1196
2016
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1
1
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1
2
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1
1
4
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8
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1
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6
1
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4
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6
1
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2
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731279
Cahn
Cofactor specificity motifs an ...
Alicyclobacillus acidocaldarius subsp. acidocaldarius, Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM446, Azotobacter vinelandii, Azotobacter vinelandii ATCC BAA-1303, Ignisphaera aggregans, Ignisphaera aggregans DSM 17230, Ignisphaera aggregans DSM17230, uncultured archaeon
Biochem. J.
468
475-484
2015
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4
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4
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16
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11
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16
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1
1
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8
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8
4
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4
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16
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16
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1
1
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-
737785
Reisse
Identification and optimizatio ...
Meiothermus ruber, Meiothermus ruber DSM 1279
Biochimie
108
76-84
2015
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-
1
-
1
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5
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3
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1
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4
1
1
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1
5
1
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2
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1
2
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1
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5
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1
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4
1
1
-
1
5
1
-
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-
-
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5
5
738989
Verdel-Aranda
Molecular annotation of ketol- ...
Corynebacterium glutamicum, Escherichia coli, Streptomyces ambofaciens, Streptomyces ambofaciens ATCC 23877, Streptomyces avermitilis, Streptomyces avermitilis DSM 46492, Streptomyces coelicolor, Streptomyces coelicolor ATCC BAA-471, Streptomyces coelicolor BAA-471, Streptomyces griseus, Streptomyces lividans, Streptomyces lividans TK24, Streptomyces pristinaespiralis, Streptomyces viridifaciens
Microb. Biotechnol.
8
239-252
2015
-
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72
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22
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114
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72
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72
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-
114
-
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72
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-
79
81
735831
Oh
Production of 2-butanol from c ...
Klebsiella pneumoniae subsp. pneumoniae, Klebsiella pneumoniae subsp. pneumoniae ATCC 700721
Biotechnol. Lett.
36
57-62
2014
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1
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739528
Brinkmann-Chen
General approach to reversing ...
Alicyclobacillus acidocaldarius subsp. acidocaldarius, Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446, Methanococcus aeolicus, Methanococcus aeolicus DSM 17508
Proc. Natl. Acad. Sci. USA
110
10946-10951
2013
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3
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9
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10
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10
10
725718
Wong
Bacterial and plant ketol-acid ...
Escherichia coli
J. Mol. Biol.
424
168-179
2012
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3
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1
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711725
Liu
High throughput receptor-based ...
Oryza sativa
Chem. Biol. Drug Des.
75
228-232
2010
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5
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698065
Wang
-
The design, synthesis of amide ...
Spinacia oleracea
Front. Chem. Chin.
4
186-190
2009
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6
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699243
Liu
Synthesis, bioactivity and SAR ...
Oryza sativa
J. Enzyme Inhib. Med. Chem.
24
545-552
2009
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1
1
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16
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16
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699584
Leung
Conformational changes in a pl ...
Oryza sativa
J. Mol. Biol.
389
167-182
2009
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1
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1
1
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1
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1
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712079
Wang
-
The design, synthesis of amide ...
Brassica rapa subsp. campestris, Echinochloa crus-galli, Oryza sativa
Front. Chem.
4
186-190
2009
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684636
Omura
Targeting of mitochondrial Sac ...
Saccharomyces cerevisiae
Appl. Microbiol. Biotechnol.
78
503-513
2008
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697346
Wang
-
Molecular design, synthesis an ...
Escherichia coli, Oryza sativa, Spinacia oleracea
Chin. Chem. Lett.
19
651-654
2008
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1
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3
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3
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Differentially expressed prote ...
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Synthesis, bioactivity, theore ...
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3
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9
9
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1
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9
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9
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2
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1
2
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17
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44
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3
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1
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1
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1
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9
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9
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1
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5
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Elevated amino acid biosynthes ...
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1
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Fermentative metabolism is ind ...
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1
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1
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670482
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Synthesis, crystal structure a ...
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45
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5
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Cyclopropane-1,1-dicarboxylate ...
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2005
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6
3
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1
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2
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2
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1
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1
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6
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1
1
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6
6
3
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1
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1
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2
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2
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1
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1
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670830
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The crystal structure of a bac ...
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2005
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1
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1
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1
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1
1
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654104
McCourt
Facile crystallization of Esch ...
Escherichia coli
Acta Crystallogr. Sect. D
60
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2004
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1
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Leyval
Characterisation of the enzyme ...
Corynebacterium glutamicum
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2003
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1
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1
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1
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1
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2
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2
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2
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1
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1
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1
-
1
-
1
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1
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656519
Ahn
Crystal structure of class I a ...
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J. Mol. Biol.
328
505-515
2003
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1
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1
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1
1
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654058
Eom
Crystallization and preliminar ...
Pseudomonas aeruginosa
Acta Crystallogr. Sect. D
58
2145-2146
2002
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1
1
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1
1
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1
1
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1
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1
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1
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1
1
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-
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639187
Dumas
Enzymology, structure, and dyn ...
Escherichia coli, Spinacia oleracea, Triticum aestivum
Acc. Chem. Res.
34
399-408
2001
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1
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4
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3
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3
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6
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3
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3
1
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4
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3
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6
-
-
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-
-
-
-
-
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639186
Thomazeau
-
Structure of spinach acetohydr ...
Spinacia oleracea
Acta Crystallogr. Sect. D
56
389-397
2000
-
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1
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-
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1
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1
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1
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2
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1
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1
1
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1
-
1
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-
-
2
-
-
-
-
-
-
-
-
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-
-
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639185
Wessel
A loop deletion in the plant a ...
Spinacia oleracea
Biochemistry
37
12753-12760
1998
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1
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1
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1
2
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1
2
1
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4
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1
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1
1
2
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1
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1
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1
1
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1
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1
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2
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1
2
1
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1
-
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1
1
2
-
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1
-
-
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-
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639182
Biou
The crystal structure of plant ...
Spinacia oleracea
EMBO J.
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3405-3415
1997
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1
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-
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2
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1
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-
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-
1
1
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-
-
1
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-
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1
-
1
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-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
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639183
Rane
Reversal of the nucleotide spe ...
Escherichia coli
Arch. Biochem. Biophys.
338
83-89
1997
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7
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1
16
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1
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1
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1
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1
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2
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15
-
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1
5
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1
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7
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1
5
16
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1
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1
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1
-
-
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2
-
-
-
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15
-
-
-
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-
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-
639184
Dumas
Purification and characterizat ...
Spinacia oleracea
FEBS Lett.
408
156-160
1997
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1
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2
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2
1
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1
3
1
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1
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1
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1
1
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2
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1
2
1
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1
1
3
1
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1
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639181
Dumas
-
Interactions of plant acetohyd ...
Ipomoea purpurea, Solanum nigrum, Spinacia oleracea
Biochem. J.
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813-820
1994
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6
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3
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6
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3
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6
-
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-
-
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-
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639180
Durner
Ketol-acid reductoisomerase fr ...
Hordeum vulgare
Plant Physiol.
103
903-910
1993
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1
3
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2
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2
1
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1
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1
2
1
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1
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1
2
3
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1
2
1
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1
-
2
1
-
2
1
-
-
-
-
1
-
-
1
-
-
-
-
-
-
639178
Mrachko
The pH dependence of the kinet ...
Escherichia coli
Arch. Biochem. Biophys.
294
446-453
1992
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4
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1
1
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1
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1
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1
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2
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4
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1
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639179
Dumas
-
Isolation and kinetic properti ...
Spinacia oleracea
Biochem. J.
288
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12
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3
12
4
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1
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3
1
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1
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639177
Aulabaugh
Oxalyl hydroxamates as reactio ...
Escherichia coli
Biochemistry
29
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1990
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3
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4
1
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2
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639175
Chunduru
Mechanism of ketol acid reduct ...
Escherichia coli
Biochemistry
28
486-493
1989
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5
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3
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1
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2
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1
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2
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1
1
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1
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5
1
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3
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1
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1
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2
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639176
Dumas
Purification and characterizat ...
Spinacia oleracea
Biochem. J.
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1989
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1
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2
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1
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1
1
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1
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1
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1
1
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3
1
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2
2
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639174
Hofler
The subunit structure of alpha ...
Salmonella enterica subsp. enterica serovar Typhimurium
J. Biol. Chem.
250
877-882
1975
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1
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1
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1
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33969
Ryan
Subcellular localization of is ...
Saccharomyces cerevisiae
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1974
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639172
Shematek
A kinetic study of alpha-aceto ...
Salmonella enterica subsp. enterica serovar Typhimurium
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158
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1973
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639169
Arfin
Purification and properties of ...
Salmonella enterica subsp. enterica serovar Typhimurium
J. Biol. Chem.
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1118-1127
1969
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7
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9
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1
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639171
Kiritani
-
The reductoisomerase of Neuros ...
Neurospora crassa
J. Biol. Chem.
241
2047-2051
1966
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6
1
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5
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6
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639170
Satyanarayana
Biosynthesis of valine and iso ...
Vigna radiata var. radiata
Biochim. Biophys. Acta
110
380-388
1965
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