1.1.1.86: ketol-acid reductoisomerase (NADP+)

This is an abbreviated version, for detailed information about ketol-acid reductoisomerase (NADP+), go to the full flat file.

Reaction

(2R)-2,3-dihydroxy-3-methylbutanoate
+
NADP+
=
(2S)-2-hydroxy-2-methyl-3-oxobutanoate
+
NADPH
+
H+

Synonyms

2-hydroxy-3-keto acid reductoisomerase, acetohydroxy acid isomeroreductase, acetohydroxy acid reductoisomerase, acetohydroxy-acid isomeroreductase , acetohydroxy-acid reductoisomerase , acetohydroxyacid isomeroreductase, acetolactate reductoisomerase, AHAIR, AHIR, alpha-keto-beta-hydroxylacil reductoisomerase, alpha-keto-beta-hydroxylacyl reductoisomerase, class II ketol-acid reductoisomerase, dehydrogenase, dihydroxyisovalerate (isomerizing), dihydroxyisovalerate dehydrogenase (isomerizing), Icl1p, Ilv5p, ilvC, IlvC-PanE, IlvC1, IlvC2, isomerase, ketol acid reducto-, isomeroreductase, KARI, ketol-acid reductoisomerase, reductoisomerase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.86 ketol-acid reductoisomerase (NADP+)

KI Value

KI Value on EC 1.1.1.86 - ketol-acid reductoisomerase (NADP+)

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00002
1-aminocarbonyl-cyclopropane carboxylate
-
-
0.0203
1-aminocarbonylcyclopropanecarboxylate
-
pH 8.0, 30C, recombinant enzyme
0.031
1-carbamoylcyclopropanecarboxylic acid
-
pH 8.0, 30C
0.000058
1-cyano-cyclopropane carboxylate
-
-
207.9
1-cyano-N-[[(E)-(3,3-dichloroprop-1-yn-1-yl)diazenyl]sulfanyl]cyclopropanecarboxamide
-
-
0.0585
1-cyanocyclopropanecarboxylate
-
pH 8.0, 30C, recombinant enzyme
0.095 - 95.3
1-cyanocyclopropanecarboxylic acid
0.0056
1-hydroxycyclopropanecarboxylate
-
pH 8.0, 30C, recombinant enzyme
0.145
2,3-dihydroxy-3-isovalerate
-
pH 8.2, 30C, (2S)-2-aceto-2-hydroxybutanoate as variable substrate, 0.250 mM NADPH as fixed substrate
0.095 - 1.5
2,3-dihydroxyisovalerate
0.00019 - 0.00046
2-dimethylphosphinoyl-2-hydroxyacetic acid
0.24 - 3.6
2-hydroxy-2-methyl-3-oxopentanoate
0.35
4,4'-(pentamethylenedioxy)dibenzamidne bis(2-hydroxyethanesulfonate)
-
-
0.00009 - 0.0000903
cyclopropane-1,1-dicarboxylate
0.076
cyclopropane-1,1-dicarboxylic acid
-
pH 8.0, 30C
0.000716
dimethylmalonate
-
pH 8.0, 30C, recombinant enzyme
0.035
ethyl [(2-chlorophenyl)(hydroxy)amino](oxo)acetate
-
-
0.049
ethyl [hydroxy(2-methylphenyl)amino](oxo)acetate
-
-
0.351
ethyl [hydroxy(4-methylphenyl)amino](oxo)acetate
-
-
1.704
ethyl [[4-(cyanomethyl)phenyl](hydroxy)amino](oxo)acetate
-
-
0.0025 - 0.0032
ethylene glycol
0.034
methyl [hydroxy(1-methylethyl)amino](oxo)acetate
-
-
0.0000974 - 0.00275
N-Hydroxy-N-isopropyloxamate
0.005 - 0.33
NADP+
0.0012 - 0.0226
NADPH
additional information
1-cyano-N-(4-methylphenyl)cyclopropanecarboxamide