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Literature summary for 1.1.1.86 extracted from

  • Chunduru, S.K.; Mrachko, G.T.; Calvo, K.C.
    Mechanism of ketol acid reductoisomerase--steady-state analysis and metal ion requirement (1989), Biochemistry, 28, 486-493.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,3-dihydroxy-3-methylbutyrate
-
Escherichia coli
2-Methyllactate uncompetitive; uncompetitive with respect to NADPH Escherichia coli
3-aminopyridine-NADP+
-
Escherichia coli
Mn2+ with acetolactate as substrate, Mn2+ behaves as a competitive inhibitor in presence of Mg2+ Escherichia coli
NADP+
-
Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Escherichia coli
Mg2+ Km: 0.42 mM Escherichia coli
Mg2+ with acetolactate as substrate , Mg2+ is the only divalent metal ion that supports enzyme catalysis Escherichia coli
Mn2+ activates reaction with 3-hydroxy-3-methyl-2-oxobutanoate, no effect on reaction with acetolactate Escherichia coli
additional information Mn2+, Co2+, Ni2+, Zn2+, Ca2+, Cu2+ and Co3+ can not substitute for Mg2+ Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-acetolactate + NADPH Escherichia coli enzyme of branched chain amino acid synthesis 2,3-dihydroxy-3-methylbutanoate + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
recombinant
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-acetolactate + NADPH enzyme of branched chain amino acid synthesis Escherichia coli 2,3-dihydroxy-3-methylbutanoate + NADP+
-
r
NADPH + 2-acetolactate
-
Escherichia coli NADP+ + 3-hydroxy-3-methyl-2-oxobutyrate
-
?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information
-
Escherichia coli