1.1.1.218: morphine 6-dehydrogenase

This is an abbreviated version, for detailed information about morphine 6-dehydrogenase, go to the full flat file.

Reaction

morphine
+
NAD(P)+
=
morphinone
+
NAD(P)H
+
H+

Synonyms

morphine 6-dehydrogenase, naloxone reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.218 morphine 6-dehydrogenase

KM Value

KM Value on EC 1.1.1.218 - morphine 6-dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.12
1-Indanol
-
cosubstrate NAD+
0.92
3-hydroxyhexobarbital
-
cosubstrate NAD+
0.002
5alpha-androstan-17beta-ol-3-one
-
similar values of other 17beta-hydroxysteroids
1.75
benzenedihydrodiol
-
cosubstrate NAD+
0.033 - 0.45
codeine
0.12
codeinone
-
cosubstrate NADPH
0.54
cyclohexene-2-ol
-
cosubstrate NAD+
0.39 - 2.91
Dihydrocodeine
0.4 - 1.54
ethylmorphine
0.12 - 5.5
morphine
0.0022
NADH
-
-
0.35
NADP+
-
-
0.0065
NADPH
-
-
0.015 - 0.048
nalorphine
0.27 - 0.44
naloxone
0.044 - 0.64
normorphine
0.009
testosterone
-
cosubstrate NAD+