1.1.1.218: morphine 6-dehydrogenase

This is an abbreviated version, for detailed information about morphine 6-dehydrogenase, go to the full flat file.

Reaction

morphine
+
NAD(P)+
=
morphinone
+
NAD(P)H
+
H+

Synonyms

morphine 6-dehydrogenase, naloxone reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.218 morphine 6-dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.218 - morphine 6-dehydrogenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
-
2,2'-dipyridyl
-
-
5alpha-dihydrotestosterone
5beta-dihydrotestosterone
androsterone
Barbital
-
1mM, 68% inhibition
CdCl2
-
dithiol modifier, strong competitive inhibitor to cofactor
chenodeoxycholic acid
-
0.1 mM, 24% inhibition
cholic acid
-
0.1 mM, 10% inhibition
CuSO4
epiandrosterone
-
0.1 mM, 77% inhibition
estradiol
indomethacin
-
1 mM, 84% inhibition
iodoacetate
-
-
Ketamine
lithocholic acid
naloxone
-
1mM, 61% inhibition
p-chloromercuribenzoic acid
Phenylarsine oxide
prostaglandin E1
-
-
pyrazole
-
1 mM, 20% inhibition
quercetin
quercitrin
-
-
testosterone
additional information
-