1.1.1.218: morphine 6-dehydrogenase

This is an abbreviated version, for detailed information about morphine 6-dehydrogenase, go to the full flat file.

Reaction

morphine
+
NAD(P)+
=
morphinone
+
NAD(P)H
+
H+

Synonyms

morphine 6-dehydrogenase, naloxone reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.218 morphine 6-dehydrogenase

pH Optimum

pH Optimum on EC 1.1.1.218 - morphine 6-dehydrogenase

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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.2
-
with NADH als cofactor, 67 mM sodium phosphate buffer
6.5
-
in presence of NADPH reduction of codeinone to codeine, in MOPS buffer
6.8
-
with NADPH as cofactor, 67 mM sodium phosphate buffer
8.6
-
with NADP+ as cofactor, in glycine-NaCl-NaOH buffer
9.1
-
with NADP+ as cofactor, in tricine-NaOH buffer
9.4
-
with NAD+ as cofactor, in glycine-NaCl-NaOH buffer
9.5
-
with NADP+ as cofactor, in glycine-NaOH buffer, oxidizing the C-6 hydroxy group of morphine and codeine
9.7
-
with NAD+ as cofactor, in glycine-NaCl-NaOH buffer