1.1.1.218: morphine 6-dehydrogenase

This is an abbreviated version, for detailed information about morphine 6-dehydrogenase, go to the full flat file.

Reaction

morphine
+
NAD(P)+
=
morphinone
+
NAD(P)H
+
H+

Synonyms

morphine 6-dehydrogenase, naloxone reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.218 morphine 6-dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.218 - morphine 6-dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-indanol + NADP+
1-indanone + NADPH
show the reaction diagram
-
-
-
-
?
3-hydroxyhexobarbital + NADP+
?
show the reaction diagram
-
does not serve as a substrate for guinea pig enzyme
-
-
?
benzenedihydrodiol + NADP+
?
show the reaction diagram
-
-
-
-
?
codeine + NAD(P)+
codeinone + NAD(P)H
show the reaction diagram
codeine + NADP+
codeinone + NADPH
show the reaction diagram
cyclohexene-2-ol + NADP+
cyclohexene-2-one + NADPH
show the reaction diagram
-
-
-
-
?
dihydrocodeine + NADP+
dihydrocodeinone + NADPH
show the reaction diagram
ethylmorphine + NAD(P)+
?
show the reaction diagram
morphine + NAD(P)+
morphinone + NAD(P)H
show the reaction diagram
-
-
-
-
ir
morphine + NADP+
morphinone + NADPH
show the reaction diagram
morphine + NADP+
morphinone + NADPH + H+
show the reaction diagram
nalorphine + NAD(P)+
(5alpha)-3-hydroxy-17-(prop-2-en-1-yl)-7,8-didehydro-4,5-epoxymorphinan-6-one + NAD(P)H + H+
show the reaction diagram
naloxone + NAD(P)H
6alpha-naloxol + NADP+
show the reaction diagram
normorphine + NAD(P)+
?
show the reaction diagram
trans-1,4-decalindiol + NADP+
?
show the reaction diagram
-
about 30% of the activity observed with morphine
-
-
?