1.1.1.218: morphine 6-dehydrogenase

This is an abbreviated version, for detailed information about morphine 6-dehydrogenase, go to the full flat file.

Reaction

morphine
+
NAD(P)+
=
morphinone
+
NAD(P)H
+
H+

Synonyms

morphine 6-dehydrogenase, naloxone reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.218 morphine 6-dehydrogenase

Reference

Reference on EC 1.1.1.218 - morphine 6-dehydrogenase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yamano, S; Kageura, E.; Ishida, T.; Toki, S.
Purification and characterization of guinea pig liver morphine 6-dehydrogenase
J. Biol. Chem.
260
5259-5264
1985
Cavia porcellus, Cavia porcellus Hartley
Manually annotated by BRENDA team
Yamano, S.; Nishida, F; Toki, S.
Guinea-pig liver morphine 6-dehydrogenase as a naloxone reductase
Biochem. Pharmacol.
35
4321-4326
1986
Cavia porcellus, Cavia porcellus Hartley
Manually annotated by BRENDA team
Bruce, N.C.; Wilmot, C.J.; Jordan, K.N.; Trebilcock, A.E.; Stephens, L.D.G.; Lowe, Ch.R.
Microbial degradation of the morphine alkaloids: identification of morphinone as an intermediate in the metabolism of morphine by Pseudomonas putida M10
Arch. Microbiol.
154
465-470
1990
Pseudomonas putida, Pseudomonas putida M10
Manually annotated by BRENDA team
Bruce, N.C.; Wilmot, C.J.; Jordan, K.N.; Stephens, L.D.G.; Lowe, Ch.R.
Microbial degradation of the morphine alkaloids
Biochem. J.
274
875-880
1991
Pseudomonas putida, Pseudomonas putida M10
-
Manually annotated by BRENDA team
Walker, E.H.; Bruce, N.C.
Towards engineering an improved morphine dehydrogenase
Ann. N. Y. Acad. Sci.
799
6-10
1996
Pseudomonas putida, Pseudomonas putida M10
Manually annotated by BRENDA team
Yamano, S.; Ito, K.; Ogata, S.; Toki, S.
Purification, characterization and partial primary structure of morphine 6-dehydrogenase from rabbit liver cytosol
Arch. Biochem. Biophys.
341
81-88
1997
Oryctolagus cuniculus
Manually annotated by BRENDA team
Yamano, S.; Takahashi, A.; Todaka, T.; Toki, S.
In vivo and in vitro formation of morphinone from morphine in rat
Xenobiotica
27
645-656
1997
Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Todaka, T.; Yamano, S.; Toki, S.
Purification and characterization of NAD-dependent morphine 6-dehydrogenase from hamster liver cytosol, a new member of the aldo-keto reductase superfamily
Arch. Biochem. Biophys.
374
189-197
2000
Mesocricetus auratus
Manually annotated by BRENDA team
Walker, E.H.; French, C.E.; Rathbone, D.A.; Bruce, N.C.
Mechanistic studies of morphine dehydrogenase and stabilization against covalent inactivation
Biochem. J.
345
687-692
2000
Pseudomonas putida, Pseudomonas putida M10
Manually annotated by BRENDA team
Todaka, T.; Ishida, T.; Kita, H.; Narimatsu, S.; Yamano, S.
Bioactivation of morphine in human liver: isolation and identification of morphinone, a toxic metabolite
Biol. Pharm. Bull.
28
1275-1280
2005
Homo sapiens
Manually annotated by BRENDA team