Any feedback?
Information on EC 6.2.1.12 - 4-coumarate-CoA ligase
for references in articles please use BRENDA:EC6.2.1.12Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
6.2.1.12 4-coumarate-CoA ligaseSpecify your search results
Word Map
- 6.2.1.12
-
phenylpropanoids
- lignin
- flavonoid
-
ammonia-lyase
- chalcone
-
ferulic
-
4-hydroxylase
-
p-coumaric
- xylem
-
caffeic
- parsley
- populus
- cinnamate-4-hydroxylase
-
sinapic
-
cinnamyl
- monolignols
- crispum
- stilbene
-
lignification
-
petroselinum
- caffeate
- trans-cinnamate
- dihydroflavonol
-
4.3.1.5
- taeda
-
4-reductase
-
cinnamoylated
-
elicitor-treated
- glycinea
-
3-o-methyltransferase
-
3\'-hydroxylase
- cinnamoyl-coa
-
guaiacyl
-
hydroxycinnamoyl-coas
- megasperma
-
syringyl
- ccoaomt
-
adenylate-forming
- biotechnology
- synthesis
- drug development
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
4-coumarate:coa ligase, 4-coumarate:coenzyme a ligase, 4-coumarate-coa ligase, 4-coumarate coa ligase, 4-coumarate coenzyme a ligase, at4cl1, 4-coumaroyl-coa ligase, os4cl, 4-coumaroyl coa ligase, pl4cl1, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
4-coumarate coenzyme A ligase
4-coumarate/coenzyme A ligase
4-coumarate: CoA ligase
4-coumarate: coenzyme A ligase
4-coumarate:CoA ligase
4-coumarate:CoA-ligase
4-Coumarate:coenzyme A ligase
4-coumaroyl-CoA ligase
4-coumaroyl-CoA synthase
-
-
-
-
4-Coumaryl-CoA synthetase
-
-
-
-
4CL
4CL-A1
4CL-A2
4CL-B
4CL1
4CL2
4CL3
4CL4
Caffeolyl coenzyme A synthetase
-
-
-
-
Clone 4CL14
-
-
-
-
Clone 4CL16
-
-
-
-
Feruloyl CoA ligase
-
-
-
-
Feruloyl coenzyme A synthetase
-
-
-
-
Hydroxy-cinnamate:CoA ligase
-
-
-
-
Hydroxycinnamate:CoA ligase
-
-
-
-
Hydroxycinnamoyl CoA synthetase
-
-
-
-
OB4CL_ctg4
OS4CL
p-Coumaroyl CoA ligase
-
-
-
-
p-Coumaryl coenzyme A synthetase
-
-
-
-
p-Coumaryl-CoA ligase
-
-
-
-
p-Coumaryl-CoA synthetase
-
-
-
-
p-Hydroxycinnamic acid:CoA ligase
-
-
-
-
p-Hydroxycinnamoyl coenzyme A synthetase
-
-
-
-
Sinapoyl coenzyme A snthetase
-
-
-
-
Synthetase, p-coumaroyl coenzyme A
-
-
-
-
4-Coumarate:coenzyme A ligase
-
-
-
-
4CL
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA
-
-
-
-
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA
bi uni uni bi ping pong mechanism, catalytic reaction scheme and kinetics, overview
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acid-thiol ligation
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
KEGG
-
, , , , , Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, lipid metabolism, lipid metabolism, lipid metabolism, phenylpropanoid biosynthesis, phenylpropanoid biosynthesis, suberin monomers biosynthesis, Ubiquinone and other terpenoid-quinone biosynthesis, Ubiquinone and other terpenoid-quinone biosynthesis
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
4-coumarate:CoA ligase (AMP-forming)
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
37332-51-7
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-coumarate + MgATP2- + tetrapolyphosphate
adenosine 5'-pentaphosphate + ?
-
CoA omitted from the incubation mixture
-
r
4-coumarate + MgATP2- + tripolyphosphate
adenosine 5'-tetraphosphate + ?
-
CoA omitted from the incubation mixture
-
r
AMP + 3-oxo-2-(2'-[Z]-pentenyl)-cyclopentane-1-butanoic acid + CoA
?
-
weak substrate
-
-
?
AMP + 3-oxo-2-(2'-[Z]-pentenyl)-cyclopentane-1-hexanoic acid + CoA
?
-
weak substrate
-
-
?
ATP + (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid + CoA
?
-
-
-
-
?
ATP + 3-methoxcinnamate + CoA
AMP + diphosphate + 3-methoxycinnamoyl-CoA
-
-
-
-
?
ATP + 4-methoxyferulate + CoA
AMP + diphosphate + 4-methoxyferuloyl-CoA
-
-
-
-
?
ATP + cinnamic acid + CoA
AMP + diphosphate + cinnamoyl-CoA
-
3-phenyl-2-propenoic acid, 98%
-
-
?
ATP + decanoate + CoA
AMP + diphosphate + decanoyl-CoA
-
weak substrate
-
-
?
ATP + dihydro-4-coumarate + CoA
AMP + diphosphate + dihydro-4-coumaroyl-CoA
-
-
-
?
ATP + ferulic acid + CoA
AMP + diphosphate + 4-feruloyl-CoA
-
4-hydroxy-3-methoxycinnamic acid, 99%
-
-
?
ATP + hexadecanoate + CoA
AMP + diphosphate + hexadecanoyl-CoA
-
weak substrate
-
-
?
ATP + octadecanoate + CoA
AMP + diphosphate + octadecanoyl-CoA
-
weak substrate
-
-
?
ATP + propanoate + CoA
AMP + diphosphate + propanoyl-CoA
-
weak substrate
-
-
?
ATP + sinapic acid + CoA
AMP + diphosphate + 4-sinapoyl-CoA
-
3,5-dimethoxy-4-hydroxycinnamic acid, 98%, predominantly trans isomer
-
-
?
ATP + tetradecanoate + CoA
AMP + diphosphate + tetradecanoyl-CoA
-
-
-
-
?
CTP + ferulate + CoA
CMP + diphosphate + feruloyl-CoA
-
7.7% of the activity relative to ATP
-
-
?
GTP + ferulate + CoA
GMP + diphosphate + feruloyl-CoA
-
5.7% of the activity relative to ATP
-
-
?
ITP + ferulate + CoA
IMP + diphosphate + feruloyl-CoA
-
20.2% of the activity relative to ATP
-
-
?
MgATP2-
diadenosine 5',5'',P1,P4-tetraphosphate + ?
-
no additional substrate, CoA omitted from the incubation mixture
-
?
UTP + ferulate + CoA
UMP + diphosphate + feruloyl-CoA
-
12.5% of the activity relative to GTP
-
-
?
ATP + 2-coumarate + CoA
AMP + diphosphate + 2-coumaroyl-CoA
-
-
-
?
ATP + 3,4,5-trimethoxycinnamate + CoA
AMP + diphosphate + 3,4,5-trimethoxycinnamoyl-CoA
-
isoenzyme 1 is active, isoenzyme 2 not
-
-
?
ATP + 3,4,5-trimethoxycinnamate + CoA
AMP + diphosphate + 3,4,5-trimethoxycinnamoyl-CoA
-
no activity
-
-
?
ATP + 3,4,5-trimethoxycinnamate + CoA
AMP + diphosphate + 3,4,5-trimethoxycinnamoyl-CoA
-
no activity
-
-
?
ATP + 3,4-dimethoxycinnamate + CoA
AMP + diphosphate + 3,4-dimethoxycinnamoyl-CoA
-
84% of the activity relative to ferulate
-
-
?
ATP + 3,4-dimethoxycinnamate + CoA
AMP + diphosphate + 3,4-dimethoxycinnamoyl-CoA
-
-
-
?
ATP + 3,4-dimethoxycinnamate + CoA
AMP + diphosphate + 3,4-dimethoxycinnamoyl-CoA
-
-
?
ATP + 3,4-dimethoxycinnamate + CoA
AMP + diphosphate + 3,4-dimethoxycinnamoyl-CoA
-
isoenzyme 1 is active, isoenzyme 2 not
-
-
?
ATP + 3,4-dimethoxycinnamate + CoA
AMP + diphosphate + 3,4-dimethoxycinnamoyl-CoA
-
substrate for 4CL1 but not for 4CL2 and 4CL3
-
?
ATP + 3,4-dimethoxycinnamate + CoA
AMP + diphosphate + 3,4-dimethoxycinnamoyl-CoA
-
-
-
-
?
ATP + 3,4-dimethoxycinnamate + CoA
AMP + diphosphate + 3,4-dimethoxycinnamoyl-CoA
-
-
-
-
?
ATP + 3,4-dimethoxycinnamate + CoA
AMP + diphosphate + 3,4-dimethoxycinnamoyl-CoA
-
no activity
-
-
?
ATP + 3-coumarate + CoA
AMP + diphosphate + 3-coumaroyl-CoA
-
high activity
-
-
?
ATP + 4-coumarate + CoA
?
-
4-coumarate-CoA ligase is the last enzyme of the general phenylpropanoid metabolism, supplying substrates for lignin formation and other individual phenylpropanoid pathways
-
-
?
ATP + 4-coumarate + CoA
?
-
enzyme of B-ring-deoxy flavonoid biosymthesis
-
-
?
ATP + 4-coumarate + CoA
?
-
enzyme is involved in the resistance response of soybean against pathogen attack. The different substrate affinities for substituted cinnamic acids and the differential regulation of the 3 isoenzymes, may play a pivotal role in distributing substituted cinnamate intermediates at a branch point of general phenylpropanoid metabolism into subsequent specific pathways
-
-
?
ATP + 4-coumarate + CoA
?
-
enzyme has an important role in the determination of the composition and the amount of lignin in tobacco plants
-
-
?
ATP + 4-coumarate + CoA
?
-
key enzyme of general phenylpropanoid metabolism
-
-
?
ATP + 4-coumarate + CoA
?
-
the isoenzymes can play an important role in the control of the monomeric composition of lignins
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
52% of the activity with caffeate
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
high activity
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
plant phenylpropanoid metabolism
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
plant phenylpropanoid metabolism
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
plant phenylpropanoid metabolism
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
plant phenylpropanoid metabolism
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
plant phenylpropanoid metabolism, 4CL2 involved in coenzyme A ester formation and cocatalytic AMP-donor in (di)adenosine polyphosphate synthesis
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
plant phenylpropanoid metabolism, class II enzymes part of flavonoid pathway, class I enzymes probably involved in lignin formation and phenolic compound other than flavonoids
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
140% of the activity relative to ferulate
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
assay at pH 7.5
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
plant phenylpropanoid metabolism
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
plant phenylpropanoid metabolism
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
-
-
-
?
ATP + 4-coumarate + CoA
AMP + diphosphate + 4-coumaroyl-CoA
-
-
-
-
ir