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Ligand 4-coumaroyl-CoA

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

phenylpropanoid biosynthesis, tyrosine metabolism

KEGG

Arginine and proline metabolism, Biosynthesis of phenylpropanoids, Biosynthesis of secondary metabolites, Biosynthesis of various alkaloids, Biosynthesis of various plant secondary metabolites, Degradation of aromatic compounds, Flavonoid biosynthesis, Phenylpropanoid biosynthesis, Stilbenoid, diarylheptanoid and gingerol biosynthesis, Ubiquinone and other terpenoid-quinone biosynthesis more

MetaCyc

4-coumarate degradation (aerobic), 4-coumarate degradation (anaerobic), 4-hydroxybenzoate biosynthesis I (eukaryotes), 4-hydroxybenzoate biosynthesis III (plants), 6-gingerol analog biosynthesis (engineered), anthocyanidin acylglucoside and acylsambubioside biosynthesis, anthocyanidin modification (Arabidopsis), aromatic polyketides biosynthesis, avenanthramide biosynthesis, chlorogenic acid biosynthesis I, chlorogenic acid biosynthesis II, coumarins biosynthesis (engineered), curcuminoid biosynthesis, flavonoid biosynthesis, flavonoid biosynthesis (in equisetum), flavonoid di-C-glucosylation, flavonol acylglucoside biosynthesis I - kaempferol derivatives, flavonol acylglucoside biosynthesis II - isorhamnetin derivatives, flavonol acylglucoside biosynthesis III - quercetin derivatives, hinokiresinol biosynthesis, hordatine biosynthesis, hydroxycinnamic acid serotonin amides biosynthesis, hydroxycinnamic acid tyramine amides biosynthesis, kaempferol triglucoside biosynthesis, L-tyrosine degradation V (reductive Stickland reaction), naringenin biosynthesis (engineered), pelargonidin conjugates biosynthesis, phaselate biosynthesis, phenylphenalenone biosynthesis, phenylpropanoid biosynthesis, phloridzin biosynthesis, raspberry ketone biosynthesis, resveratrol biosynthesis, rosmarinic acid biosynthesis I, shisonin biosynthesis, spermidine hydroxycinnamic acid conjugates biosynthesis, superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside), umbelliferone biosynthesis, xanthohumol biosynthesis, yangonin biosynthesis more

Show all BRENDA pathways known for 4-coumaroyl-CoA

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (36 results)

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Show Natural Substrate (36 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.11.62

trans-4-coumaroyl-CoA + 2-oxoglutarate + O2 = 2,4-dihydroxycinnamoyl-CoA + succinate + CO2

751859

-

1.2.1.44

4-coumaroyl-CoA + NADPH + H+ = 4-coumaraldehyde + CoA + NADP+

725626, 743447, 743501, 743559, 743156, 742589, 743848, 743233

-

1.2.1.44

4-coumaroyl-CoA + NADPH + H+ = 4-coumaric aldehyde + CoA + NADP+

724494

-

1.2.1.44

4-coumaroyl-CoA + NADPH + H+ = 4-coumaroylaldehyde + CoA + NADP+

700489

-

1.2.1.44

coumaroyl-CoA + NADPH + H+ = coumaric aldehyde + CoA + NADP+

725147, 726367

-

1.2.1.44

4 entries

1.3.1.117

trans-4-coumaroyl-CoA + NADPH + H+ = dihydro-4-coumaroyl-CoA + NADP+

745999

-

2.3.1.133

4-coumaroyl-CoA + quinate = CoA + 5-(4-coumaroyl)quinate

720173

-

2.3.1.133

4-coumaroyl-CoA + shikimate = CoA + 4-coumaroylshikimate

720173

-

2.3.1.133

4-coumaroyl-CoA + shikimate = CoA + 5-O-(4-coumaroyl)shikimate

689750, 689416, 676373, 720787, 486281, 486284, 486285, 486278

-

2.3.1.140

4-coumaroyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + 2-O-(4-coumaroyl)-3-(3,4-dihydroxyphenyl)lactate

720636

-

2.3.1.140

4-coumaroyl-CoA + 3-(4-hydroxyphenyl)lactate = CoA + 2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)lactate

720636

-

2.3.1.133

3 entries

2.3.1.140

2 entries

2.3.1.144

coumaroyl-CoA + anthranilate = CoA + N-(4-hydroxycinnamoyl)-anthranilate

718662

-

2.3.1.170

malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = CoA + isoliquiritigenin + CO2 + NADP+ + H2O

3733

-

2.3.1.173

4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]

657434

-

2.3.1.211

2 4-coumaroyl-CoA + malonyl-CoA + H2O = 3 CoA + bisdemethoxycurcumin + 2 CO2

694037, 721196, 722042, 676373, 722655

-

2.3.1.212

4-coumaroyl-CoA + malonyl-CoA + H2O = 2 CoA + 4-hydroxybenzalacetone + 2 CO2

723358, 723451, 684699, 721184, 721796, 721798, 722174, 722314, 722633, 723327, 723330

-

2.3.1.215

4-hydroxycinnamoyl-CoA + cyanidin 3-O-beta-D-glucoside = CoA + ?

720758

-

2.3.1.215

4-hydroxycinnamoyl-CoA + delphinidin 3-O-beta-D-glucoside = CoA + ?

720758

-

2.3.1.215

4-hydroxycinnamoyl-CoA + pelargonidin 3-O-beta-D-glucoside = CoA + ?

720758

-

2.3.1.215

3 entries

2.3.1.218

4-coumaroyl-CoA + malonyl-CoA = (4-coumaroyl)acetyl-CoA + CO2 + CoA

719850

-

2.3.1.219

(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O = bisdemethoxycurcumin + 2 CO2 + CoA

719493

-

2.3.1.219

(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O = bisdemethoxycurcumin + CO2 + CoA

719850

-

2.3.1.219

4-coumaroyl-CoA + feruloylacetyl-CoA = demethoxycurcumin + CO2 + CoA

719850, 719493

-

2.3.1.219

3 entries

2.3.1.229

4-coumaroyl-CoA + S-adenosyl-L-methionine = CoA + S-methyl-5'-thioadenosine + N-(4-coumaroyl)-L-homoserine lactone

726035

-

2.3.1.249

2 4-coumaroyl-CoA + spermidine = 2 CoA + N1,N8-bis(4-coumaroyl)-spermidine

734888

-

2.3.1.64

4-coumaroyl-CoA + agmatine = CoA + 4-coumaroylagmatine

758017, 487360

-

2.3.1.64

p-coumaroyl-CoA + agmatine = CoA + p-coumaroylagmatine

706386

-

2.3.1.64

p-coumaroyl-CoA + putrescine = CoA + p-coumaroylputrescine

706386

-

2.3.1.74

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2

756987, 757756, 756665, 706346, 756820, 757913, 757970, 706814, 757489, 757784, 755796, 755721, 756166, 756731, 756859, 758097

-

2.3.1.74

4-coumaroyl-CoA + 3 malonyl-CoA = naringenin chalcone + 4 CoA + 3 CO2

487453, 487467, 95079, 487463, 487470, 487460, 487461, 3733, 672501

-

2.3.1.74

3 malonyl-CoA + 4-hydroxycinnamoyl-CoA = 4 CoA + naringenin chalcone

705629

-

2.3.1.95

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + trans-resveratrol + 4 CO2

718636, 706278, 720646, 721047

-

2.3.1.95

4-coumaroyl-CoA + malonyl-CoA = 3,4',5-trihydroxystilbene + CoA + CO2

487453

-

2.3.1.99

4-coumaroyl-CoA + quinate = CoA + 4-coumaroylquinate

720787

-

2.3.1.99

p-coumaroyl-CoA + quinate = CoA + 5-O-(p-coumaroyl)quinate

702918

-

2.3.1.64

3 entries

2.3.1.74

3 entries

2.3.1.95

2 entries

2.3.1.99

2 entries

4.1.2.61

4-coumaroyl-CoA = 4-hydroxybenzaldehyde + acetyl-CoA

653573

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.2.1.12

ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA

0, 653527, 652422, 651262, 653481, 653597, 653015, 653496, 651117, 652146, 653536, 653477

-

Substrate in Enzyme-catalyzed Reactions (130 results)

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Show Substrate (130 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.11.61

trans-4-coumaroyl-CoA + 2-oxoglutarate + O2 = 2,4-dihydroxycinnamoyl-CoA + succinate + CO2

751859

-

1.14.11.62

trans-4-coumaroyl-CoA + 2-oxoglutarate + O2 = 2,4-dihydroxycinnamoyl-CoA + succinate + CO2

751859

-

1.2.1.44

4-coumaroyl-CoA + NADPH + H+ = 4-coumaraldehyde + CoA + NADP+

725626, 762841, 763766, 743447, 763103, 763599, 763691, 672472, 743501, 743559, 743156, 742589, 743848, 743233

-

1.2.1.44

4-coumaroyl-CoA + NADPH + H+ = 4-coumaric aldehyde + CoA + NADP+

724494

-

1.2.1.44

4-coumaroyl-CoA + NADPH + H+ = 4-coumaroylaldehyde + CoA + NADP+

700489

-

1.2.1.44

coumaroyl-CoA + NADPH + H+ = coumaraldehyde + CoA + NADP+

675132

-

1.2.1.44

coumaroyl-CoA + NADPH + H+ = coumaric aldehyde + CoA + NADP+

725147, 726367

-

1.2.1.44

p-coumaroyl-CoA + NADPH + H+ = p-coumaraldehyde + CoA + NADP+

676643, 676451

-

1.2.1.44

p-coumaroyl-CoA + NADPH = p-coumaric aldehyde + CoA + NADP+

288230, 288228, 288235, 288233, 288234

-

1.2.1.44

7 entries

1.3.1.108

4-coumaroyl-CoA + 2 NADH + 2 oxidized ferredoxin iron-sulfur cluster = ? + 2 NAD+ + 2 reduced ferredoxin iron-sulfur cluster

732091

-

1.3.1.117

trans-4-coumaroyl-CoA + NADPH + H+ = dihydro-4-coumaroyl-CoA + NADP+

745999

-

1.3.1.85

4-coumaroyl-CoA + NADPH + CO2 + H+ = (2S)2-carboxy-3-(4-hydroxyphenyl)propionyl-CoA + NADP+

739852

-

2.1.1.104

S-adenosyl-L-methionine + 4-coumaroyl-CoA = S-adenosyl-L-homocysteine + ?

758087

-

2.3.1.106

p-coumaroyl-CoA + tartronic acid = CoA + p-coumaroyltartronic acid

486106

-

2.3.1.110

4-coumaroyl-CoA + octopamine = CoA + N-(4-coumaroyl)octopamine

486133

-

2.3.1.110

4-coumaroyl-CoA + phenethylamine = CoA + N-(4-coumaroyl)phenethylamine

720789

-

2.3.1.110

4-coumaroyl-CoA + tryptamine = CoA + N-(4-coumaroyl)tryptamine

720789

-

2.3.1.110

4-coumaroyl-CoA + tyramine = CoA + N-(4-coumaroyl)tyramine

486130, 486131, 486133, 486132, 486128, 486134, 676598, 720789, 486126, 486127, 660244

-

2.3.1.110

4 entries

2.3.1.126

4-coumaroyl-CoA + isocitrate = CoA + 4-coumaroylisocitrate

486247

-

2.3.1.130

p-coumaroyl-CoA + galactarate = CoA + O-p-coumaroylgalactarate

486275

-

2.3.1.131

p-coumaroyl-CoA + glucarate = CoA + p-coumaroylglucarate

486275

-

2.3.1.132

p-coumaroyl-CoA + glucarolactone = CoA + O-p-coumaroylglucarolactone

486275

-

2.3.1.133

4-coumaroyl-CoA + 2,3-dihydroxybenzoate = CoA + 3-O-(4-coumaroyl)oxy-2-hydroxybenzoate

736977

-

2.3.1.133

4-coumaroyl-CoA + 2,3-dihydroxybenzoate = CoA + ?

720787

-

2.3.1.133

4-coumaroyl-CoA + 3,4-dihydroxybenzoate = CoA + 3-O-(4-coumaroyl)oxy-4-hydroxybenzoate

736977

-

2.3.1.133

4-coumaroyl-CoA + 3-aminobenzoate = CoA + 3-N-(4-coumaroyl)aminobenzoate

736977

-

2.3.1.133

4-coumaroyl-CoA + 3-aminobenzoate = CoA + ?

720787

-

2.3.1.133

4-coumaroyl-CoA + 3-hydroxyanthranilate = CoA + 3-(4-coumaroyl)oxyanthranilate

720787, 736977

-

2.3.1.133

4-coumaroyl-CoA + 3-hydroxybenzoate = CoA + 3-(4-coumaroyl)oxybenzoate

720787

-

2.3.1.133

4-coumaroyl-CoA + 3-hydroxybenzoate = CoA + 3-O-(4-coumaroyl)oxy-benzoate

736977

-

2.3.1.133

4-coumaroyl-CoA + 5-hydroxyanthranilate = CoA + 5-(4-coumaroyl)oxyanthranilate

736977

-

2.3.1.133

4-coumaroyl-CoA + catechol = CoA + 1-(4-coumaroyl)catechol

736977

-

2.3.1.133

4-coumaroyl-CoA + catechol = CoA + 1-O-(4-coumaroyl)catechol

736977

-

2.3.1.133

4-coumaroyl-CoA + gentisate = CoA + 5-O-(4-coumaroyl)gentisate

736977

-

2.3.1.133

4-coumaroyl-CoA + glycerol = CoA + 2-O-(4-coumaroyl)glycerol + 1-O-(4-coumaroyl)glycerol

720638

-

2.3.1.133

4-coumaroyl-CoA + hydroquinone = CoA + 1-(4-coumaroyl)hydroquinone

736977

-

2.3.1.133

4-coumaroyl-CoA + hydroquinone = CoA + 1-O-(4-coumaroyl)hydroquinone

736977

-

2.3.1.133

4-coumaroyl-CoA + L-malate = CoA + 2-O-(4-coumaryl)-L-malate

706306

-

2.3.1.133

4-coumaroyl-CoA + quinate = CoA + 4-coumaroylquinate

486281, 486278, 486280, 486282, 486285, 702918, 706306, 720173

-

2.3.1.133

4-coumaroyl-CoA + quinate = CoA + 5-(4-coumaroyl)quinate

720173

-

2.3.1.133

4-coumaroyl-CoA + quinate = CoA + 5-O-(4-coumaroyl)quinate

758066, 737024

-

2.3.1.133

4-coumaroyl-CoA + shikimate = CoA + 4-coumaroylshikimate

758066, 720173

-

2.3.1.133

4-coumaroyl-CoA + shikimate = CoA + 5-O-(4-coumaroyl)shikimate

689750, 689416, 486284, 486281, 720638, 676373, 486279, 486278, 486282, 486285, 706306, 720787, 737024, 736977, 486275, 486280, 486283

-

2.3.1.138

4-coumaroyl-CoA + putrescine = CoA + N-coumaroylputrescine

757363

-

2.3.1.138

coumaroyl-CoA + putrescine = CoA + N-coumaroylputrescine

486313, 486315

-

2.3.1.140

4-coumaroyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + 2-O-(4-coumaroyl)-3-(3,4-dihydroxyphenyl)lactate

660118, 486321, 720787, 756266, 720636, 676710

-

2.3.1.140

4-coumaroyl-CoA + 3-(4-hydroxyphenyl)lactate = CoA + 2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)lactate

486321, 720787, 756266, 720636, 720789, 676710

-

2.3.1.140

4-coumaroyl-CoA + D-phenyllactate = CoA + (R)-2-O-(4-coumaroyl)-3-phenyllactate

720787

-

2.3.1.140

4-coumaroyl-CoA + D-tyrosine = CoA + N-(4-coumaroyl)-D-tyrosine

720787

-

2.3.1.140

4-coumaroyl-CoA + mandelate = CoA + 2-O-(4-coumaroyl)-3-phenyllactate

756266

-

2.3.1.140

4-coumaroyl-CoA + phenyllactate = CoA + 2-O-(4-coumaroyl)-3-phenyllactate

756266

-

2.3.1.140

4-coumaroyl-CoA + shikimate = CoA + 5-O-(4-coumaroyl)shikimate

720789

-

2.3.1.140

4-coumaroyl-CoA + tyrosol = CoA + 2-O-(4-coumaroyl)tyrosol

756266

-

2.3.1.144

4-coumaroyl-CoA + 3-hydroxyanthranilate = CoA + N-(4-coumaroyl)-3-hydroxyanthranilate

718662

-

2.3.1.144

4-coumaroyl-CoA + anthranilate = CoA + N-(4-coumaroyl)-anthranilate

718662

-

2.3.1.144

4-coumaroyl-CoA + anthranilate = CoA + N-4-(coumaroyl)anthranilate

736747, 486330

-

2.3.1.144

coumaroyl-CoA + anthranilate = CoA + N-(4-hydroxycinnamoyl)-anthranilate

718662

-

2.3.1.146

4-hydroxycinnamoyl-CoA + malonyl-CoA = cis-2-acetylresveratrol + CoA + CO2

703204

-

2.3.1.146

p-coumaroyl-CoA + 3 malonyl-CoA = resveratrol + 4 CoA + 4 CO2

637803, 637806

-

2.3.1.146

p-coumaroyl-CoA + 4 malonyl-CoA = 2-malonylresveratrol + 5 CoA + 5 CO2

703204

-

2.3.1.133

21 entries

2.3.1.138

2 entries

2.3.1.140

8 entries

2.3.1.144

4 entries

2.3.1.146

3 entries

2.3.1.151

2 malonyl-CoA + 4-coumaroyl-CoA = 3 CoA + 4-hydroxy-6-[(E)-2-(4-hydroxyphenyl)ethenyl]-2H-pyran-2-one + 2 CO2

720639

-

2.3.1.153

cyanidin-3,5-O-beta-D-diglucoside + 4-coumaroyl-CoA = CoA + cyanidin 3-O-beta-D-glucoside-5-O-(6-O-4-coumaroyl)-beta-D-glucoside

16329

-

2.3.1.153

delphinidin 3,5-di-O-beta-D-glucoside + 4-coumaroyl-CoA = CoA + delphinidin 3-O-beta-D-glucoside-5-O-(6-O-4-coumaroyl)-beta-D-glucoside

16329

-

2.3.1.159

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2

736426

-

2.3.1.159

4-coumaroyl-CoA + 3 malonyl-CoA = naringenin chalcone + 4 CoA + 3 CO2

673581

-

2.3.1.159

malonyl-CoA + 4-coumaroyl-CoA = CoA + naringenin chalcone

486401, 486402

-

2.3.1.153

2 entries

2.3.1.159

3 entries

2.3.1.170

malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = CoA + isoliquiritigenin + CO2 + NADP+ + H2O

3733

-

2.3.1.173

4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]

657434

-

2.3.1.188

p-coumaroyl-CoA + 16-hydroxypalmitic acid = CoA + (E)-16-(3-(4-hydroxyphenyl)acryloyloxy)hexadecanoic acid

700658, 700854

-

2.3.1.211

2 4-coumaroyl-CoA + malonyl-CoA + H2O = 3 CoA + bisdemethoxycurcumin + 2 CO2

694037, 721196, 722042, 676373, 722655, 757419

-

2.3.1.211

4-coumaroyl-CoA + 3-oxodecanoyl-CoA = (1E,4Z)-5-hydroxy-1-(4-hydroxyphenyl)dodeca-1,4-dien-3-one + CoA + CO2 + H2O

722042

-

2.3.1.211

4-coumaroyl-CoA + 3-oxododecanoyl-CoA = (1E,4Z)-5-hydroxy-1-(4-hydroxyphenyl)tetradeca-1,4-dien-3-one + CoA + CO2 + H2O

722042

-

2.3.1.211

4-coumaroyl-CoA + 3-oxooctanoyl-CoA = (1E,4Z)-5-hydroxy-1-(4-hydroxyphenyl)deca-1,4-dien-3-one + CoA + CO2 + H2O

722042

-

2.3.1.211

4-coumaroyl-CoA + 3-oxotetradecanoyl-CoA = (1E,4Z)-5-hydroxy-1-(4-hydroxyphenyl)hexadeca-1,4-dien-3-one + CoA + CO2 + H2O

722042

-

2.3.1.211

4-coumaroyl-CoA + cinnamoyl-CoA + malonyl-CoA + H2O = 3 CoA + cinnamoyl-4-coumaroyl-methane + 2 CO2

694037

-

2.3.1.212

4-coumaroyl-CoA + (2RS)-methylmalonyl-CoA + H2O = 2 CoA + 1-(4-hydroxyphenyl)pent-1-en-3-one + 2 CO2

722314

-

2.3.1.212

4-coumaroyl-CoA + malonyl-CoA + H2O = 2 CoA + 4-hydroxybenzalacetone + 2 CO2

723358, 723451, 684699, 721184, 721796, 721798, 722174, 722314, 722633, 723327, 723330, 757902, 757487

-

2.3.1.212

4-coumaroyl-CoA + methylmalonyl-CoA + H2O = 2 CoA + 1-(4-hydroxyphenyl)pent-1-en-3-one + 2 CO2

723327

-

2.3.1.212

4-coumaroylCoA + 2 malonyl-CoA + H2O = 2 CoA + bisnoryangonin + 2 CO2

721798, 721796

-

2.3.1.215

4-hydroxycinnamoyl-CoA + cyanidin 3,5-O-beta-D-diglucoside = CoA + cyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucosyl]-5-O-beta-D-glucoside

723385

-

2.3.1.215

4-hydroxycinnamoyl-CoA + cyanidin 3-O-beta-D-glucoside = CoA + ?

720758

-

2.3.1.215

4-hydroxycinnamoyl-CoA + cyanidin 3-O-beta-D-glucoside = CoA + cyanidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside]

723385

-

2.3.1.215

4-hydroxycinnamoyl-CoA + delphinidin 3,5-O-beta-D-diglucoside = CoA + delphinidin 3-O-(4-coumaroyl)-beta-D-glucoside-5-O-beta-D-glucoside

723385

-

2.3.1.215

4-hydroxycinnamoyl-CoA + delphinidin 3-O-beta-D-glucoside = CoA + ?

720758

-

2.3.1.215

4-hydroxycinnamoyl-CoA + delphinidin 3-O-beta-D-glucoside = CoA + delphinidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside]

723385

-

2.3.1.215

4-hydroxycinnamoyl-CoA + pelargonidin 3,5-O-beta-D-diglucoside = CoA + pelargonidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucosyl]-5-O-beta-D-glucoside

723385

-

2.3.1.215

4-hydroxycinnamoyl-CoA + pelargonidin 3-O-beta-D-glucoside = CoA + ?

720758

-

2.3.1.215

4-hydroxycinnamoyl-CoA + pelargonidin 3-O-beta-D-glucoside = CoA + pelargonidin 3-O-[6-O-(4-hydroxycinnamoyl)-beta-D-glucoside]

723385

-

2.3.1.215

malvidin 3-O-beta-D-glucoside + coumaroyl-CoA = CoA + malvidin 3-O-(6-O-coumaroyl)-beta-D-glucoside

737034

-

2.3.1.215

anthocyanidin 3-rhamnosylglucoside-5-glucoside + p-coumaroyl-CoA = CoA + anthocyanidin 3-(p-coumaroyl)rhamnosylglucoside-5-glucoside

676672

-

2.3.1.215

delphinidin 3-rhamnosylglucoside-5-glucoside + p-coumaroyl-CoA = CoA + delphinidin 3-(p-coumaroyl)rhamnosylglucoside-5-glucoside

676672

-

2.3.1.215

malvidin 3-rhamnosylglucoside-5-glucoside + p-coumaroyl-CoA = CoA + malvidin 3-(p-coumaroyl)rhamnosylglucoside-5-glucoside

676672

-

2.3.1.215

petunidin 3-rhamnosylglucoside-5-glucoside + p-coumaroyl-CoA = CoA + petunidin 3-(p-coumaroyl)rhamnosylglucoside-5-glucoside

676672

-

2.3.1.211

6 entries

2.3.1.212

4 entries

2.3.1.215

14 entries

2.3.1.218

4-coumaroyl-CoA + malonyl-CoA = (4-coumaroyl)acetyl-CoA + CO2 + CoA

719850

-

2.3.1.219

(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O = bisdemethoxycurcumin + 2 CO2 + CoA

719493

-

2.3.1.219

(4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O = bisdemethoxycurcumin + CO2 + CoA

719850

-

2.3.1.219

4-coumaroyl-CoA + (4-coumaroyl)acetyl-CoA + H2O = 2 CoA + bidemethoxycurcumin + CO2

758333

-

2.3.1.219

4-coumaroyl-CoA + cinnamoyl-diketide-N-acetylcysteamine + H2O = CoA + cinnamoyl-4-coumaroylmethane + N-acetylcysteamine

719850

-

2.3.1.219

4-coumaroyl-CoA + feruloylacetyl-CoA = demethoxycurcumin + CO2 + CoA

719850, 719493

-

2.3.1.219

5 entries

2.3.1.229

4-coumaroyl-CoA + S-adenosyl-L-methionine = CoA + S-methyl-5'-thioadenosine + N-(4-coumaroyl)-L-homoserine lactone

726035

-

2.3.1.249

2 4-coumaroyl-CoA + spermidine = 2 CoA + N1,N8-bis(4-coumaroyl)-spermidine

734888

-

2.3.1.302

p-coumaroyl-CoA + 4-hydroxyanthranilate = avenanthramide G + CoA

762520, 761938

-

2.3.1.302

p-coumaroyl-CoA + 5-hydroxyanthranilate = avenanthramide A + CoA

762520, 761814, 761938

-

2.3.1.302

p-coumaroyl-CoA + anthranilate = avenanthramide D + CoA

762520, 761938

-

2.3.1.302

p-coumaroyl-CoA + L-tyrosine = ? + CoA

762175

-

2.3.1.64

4-coumaroyl-CoA + agmatine = CoA + 4-coumaroylagmatine

487360, 487363, 758017, 487362, 487361

-

2.3.1.64

p-coumaroyl-CoA + agmatine = CoA + p-coumaroylagmatine

706386

-

2.3.1.64

p-coumaroyl-CoA + putrescine = CoA + p-coumaroylputrescine

706386

-

2.3.1.74

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2

756987, 757756, 756665, 706346, 756820, 757913, 757970, 719618, 706185, 706814, 737069, 736980, 757489, 757784, 755796, 755721, 756166, 756731, 756859, 758097, 757487, 758151

-

2.3.1.74

4-coumaroyl-CoA + (2RS)-methylmalonyl-CoA = 1-(4-hydroxyphenyl)pent-1-en-3-one

758097

-

2.3.1.74

4-coumaroyl-CoA + 3 malonyl-CoA = 4-coumaroyltriacetic acid lactone + 4 CoA + 3 CO2

720073

-

2.3.1.74

4-coumaroyl-CoA + 3 malonyl-CoA = naringenin chalcone + 4 CoA + 3 CO2

487453, 487467, 95079, 487463, 487470, 487460, 660170, 672501, 487479, 663042, 676286, 676378, 676727, 684699, 487461, 3733

-

2.3.1.74

malonyl CoA + 4-coumaroyl-CoA + NADH = 6'-deoxychalcone + CoA + CO2 + NAD+

487467, 3733, 487481, 487451, 487482

-

2.3.1.74

malonyl-CoA + 4-coumaroyl-CoA + NADPH = 5'-deoxyflavanone + CoA + CO2 + NADP+

3733, 487451

-

2.3.1.74

malonyl-CoA + 4-coumaroyl-CoA = naringenin chalcone + CoA + CO2

487466, 487478, 487457, 487451, 487453, 487459, 487463, 487456, 487468, 487469, 487471, 487470, 487460, 487472, 487483, 487450, 487454, 487464, 487484, 487461, 487455, 3733, 487475, 487474

-

2.3.1.74

3 malonyl-CoA + 4-hydroxycinnamoyl-CoA = 4 CoA + naringenin chalcone

705629

-

2.3.1.95

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + resveratrol + 4 CO2

736807

-

2.3.1.95

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + trans-resveratrol + 4 CO2

718636, 706278, 720646, 721047

-

2.3.1.95

4-coumaroyl-CoA + malonyl-CoA = 3,4',5-trihydroxystilbene + CoA + CO2

487453, 487728, 487729, 487726, 487730, 487723

-

2.3.1.99

4-coumaroyl-CoA + quinate = CoA + 4-coumaroylquinate

720787

-

2.3.1.99

4-coumaroyl-CoA + quinate = CoA + 5-O-(4-coumaroyl)quinate

487788, 676373, 486281, 486282, 672814, 758066, 756137, 487784, 487783, 486280, 486275

-

2.3.1.99

4-coumaroyl-CoA + shikimate = CoA + 4-coumaroylshikimate

758066

-

2.3.1.99

4-coumaroyl-CoA + shikimate = CoA + 5-O-(4-coumaroyl)shikimate

756137

-

2.3.1.99

p-coumaroyl-CoA + quinate = CoA + 5-O-(p-coumaroyl)quinate

659983, 486285, 702918

-

2.3.1.99

p-coumaroyl-CoA + shikimate = CoA + 5-O-(p-coumaroyl)shikimate

486275, 486285, 659983, 487783, 486280

-

2.3.1.302

4 entries

2.3.1.64

3 entries

2.3.1.74

8 entries

2.3.1.95

3 entries

2.3.1.99

6 entries

3.1.2.4

p-coumaroyl-CoA + H2O = p-coumaric acid + CoA

710261

-

4.1.2.61

4-coumaroyl-CoA + H2O = 4-hydroxybenzaldehyde + acetyl-CoA

757268

-

4.1.2.61

4-coumaroyl-CoA = 4-hydroxybenzaldehyde + acetyl-CoA

653573

-

4.1.2.61

4-hydroxycinnamoyl-CoA + H2O = 4-hydroxybenzaldehyde + acetyl-CoA

210668

-

4.1.2.61

p-coumaroyl-CoA = 4-hydroxy-3-methoxy-benzaldehyde + acetyl-CoA

682467

-

4.1.2.61

4 entries

Product in Enzyme-catalyzed Reactions (6 results)

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Show Product (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.8.3.23

3,4-dihydroxyphenylpropanoyl-CoA + 4-coumarate = 3,4-dihydroxyphenylpropanoate + 4-coumaroyl-CoA

0

-

4.2.1.175

(R)-3-(4-hydroxyphenyl)lactoyl-CoA = (E)-4-coumaroyl-CoA + H2O

0

-

6.2.1.12

ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA

0, 595, 653527, 608, 652422, 651262, 653481, 653536, 653597, 653015, 653496, 651117, 653477, 652146

-

6.2.1.2

ATP + trans-4-coumaric acid + CoA = AMP + diphosphate + trans-4-coumaroyl-CoA

0

-

6.2.1.30

ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaryl-CoA

0

-

6.2.1.30

ATP + trans-4-coumaric acid + CoA = AMP + diphosphate + trans-4-coumaroyl-CoA

0

-

6.2.1.30

2 entries

Inhibitor in Enzyme-catalyzed Reactions (6 results)

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Show Inhibitors (6 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.237

-

286351

-

1.1.1.237

50% inhibition at 0.5 mM

286350

-

1.1.1.237

2 entries

2.3.1.140

severe substrate inhibition of 4-coumaroyl-CoA with 3-(4-hydroxyphenyl)lactate as acceptor and less with 3-(3,4-dihydroxyphenyl)lactate

720636

-

2.3.1.64

the presence of this substrate inhibits the enzyme reaction with feruloyl-CoA

706386

-

2.3.1.74

above 0.01 mM

487463

-

2.3.1.74

substrate inhibition above 0.03 mM

487454

-

2.3.1.74

2 entries

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (1 entry)

EC NUMBER

ENZYME 3D STRUCTURE

2.3.1.133

5kjt, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (53 results)

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Show Turnover Number (53 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.2.1.44

0.0000265

-

pH 6.0, 25°C, recombinant GST-tagged enzyme

742589

1.2.1.44

0.0142

-

pH 6.0, 40°C, recombinant His-tagged mutant F155Y

743559

1.2.1.44

0.0183

-

pH 6.0, 40°C, recombinant His-tagged enzyme

743559

1.2.1.44

0.019

-

isoform CCR21, at pH 6.3 and 30°C

763103

1.2.1.44

0.02

-

pH 6.5, 30°C, mutant T154A

743501

1.2.1.44

0.031

-

mutant S123T of isoform CCR1, pH and temperature not specified in the publication

763599

1.2.1.44

0.05

-

pH 6.5, 30°C, wild-type enzyme

743501

1.2.1.44

0.129

-

isoform CCR20, at pH 6.3 and 30°C

763103

1.2.1.44

0.188

-

100 mM sodium/potassium phosphate buffer pH 6.3, 250 mM NADPH

700489

1.2.1.44

0.232

-

isoform CCR2-1, pH and temperature not specified in the publication

763599

1.2.1.44

0.32

-

100 mM sodium/potassium phosphate buffer pH 6.3, 250 mM NADPH

700489

1.2.1.44

0.324

-

isoform CCR1, pH and temperature not specified in the publication

763599

1.2.1.44

0.353

-

isoform CCR19, at pH 6.3 and 30°C

763103

1.2.1.44

0.43

-

CCR1

675132

1.2.1.44

1.2

-

recombinant isozyme CCR1, pH 6.0, 25°C

743447

1.2.1.44

1.63

-

-

676643

1.2.1.44

8.42

-

pH 6.5, 30°C, mutant Y154Y

743501

1.2.1.44

105

-

in 100 mM phosphate buffer pH 6.5, at 30°C

725147

1.2.1.44

18 entries

1.3.1.117

0.0019

-

pH 50, 35°C

745999

1.3.1.85

0.0735

-

mutant enzyme V350A, pH and temperature not specified in the publication

739852

1.3.1.85

0.109

-

mutant enzyme V350G, pH and temperature not specified in the publication

739852

2.3.1.159

0.034

-

pH 7.0, 30°C

673581

2.3.1.159

0.113

-

pH 7.0, 30°C

736426

2.3.1.212

0.01

-

pH 9.5, 35°C

757487

2.3.1.212

0.011

-

at pH 9.5 and 50°C

757487

2.3.1.212

0.0298

-

pH 8.0, 30°C, recombinant wild-type enzyme

722174, 722633, 723330

1.3.1.85

2 entries

2.3.1.159

2 entries

2.3.1.212

3 entries

2.3.1.215

0.13

-

pH 6.5, 30°C

737034

2.3.1.219

0.006

-

pH 7.5, 37°C, CURS2

719493

2.3.1.219

0.0142

-

pH 7.5, 37°C, CURS2

719493

2.3.1.219

0.0157

-

pH 7.5, 37°C, CURS2

719493

2.3.1.219

3.15

-

pH 8.0, 37°C, with cinnamoyl-diketide-N-acetylcysteaminyl-CoA

719850

2.3.1.219

4 entries

2.3.1.249

3.4

-

pH 7.3, 30°C, recombinant His6-tagged enzyme

734888

2.3.1.74

0.007

-

pH 7.0, 35°C, mutant enzyme L263M/F265Y/S338G

660170

2.3.1.74

0.0167

-

pH 8.0, 30°C

663042

2.3.1.74

0.02

-

pH 7.0, 37°C

755721

2.3.1.74

0.0202

-

pH 7.0, 37°C

755721

2.3.1.74

0.021

-

-

487479

2.3.1.74

0.042

-

pH 7.0, 35°C, wild-type enzyme

660170

2.3.1.74

0.045

-

at pH 7.5 and 40°C

757487

2.3.1.74

0.045

-

pH 9.5, 35°C

757487

2.3.1.74

0.05

-

mutant enzyme Q82P, at pH 8.0, temperature not specified in the publication

756731

2.3.1.74

0.085

-

mutant enzyme Q82P/C198F, at pH 8.0, temperature not specified in the publication

756731

2.3.1.74

0.087

-

in the presence of 0.001 mM chalcone isomerase-like protein CHIL, at pH 7.5 and 30°C

757756

2.3.1.74

0.11

-

wild type enzyme, at pH 8.0, temperature not specified in the publication

756731

2.3.1.74

0.178

-

mutant enzyme R105Q, at pH 8.0, temperature not specified in the publication

756731

2.3.1.74

1.27

-

in the absence of chalcone isomerase-like protein CHIL, at pH 7.5 and 30°C

757756

2.3.1.95

0.0005

-

pH 4.0, 30°C, recombinant STS

718636

2.3.1.95

0.0017

-

pH 4.0, 30°C, recombinant STS

718636

2.3.1.95

0.0023

-

pH 4.0, 30°C, recombinant STS

718636

2.3.1.95

0.003

-

pH 4.0, 30°C, recombinant STS

718636

2.3.1.95

0.02

-

-

487729

2.3.1.74

14 entries

2.3.1.95

5 entries

2.3.1.99

1.88

-

cosubstrate quinate, pH not specified in the publication, 30°C

756137

4.1.2.61

2.3

-

at 30°C

210668

K_M Value (137 results)

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Show KM Value (137 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.2.1.44

0.00227

-

-

676643

1.2.1.44

0.0028

-

pH and temperature not specified in the publication

725626

1.2.1.44

0.00427

-

-

288228

1.2.1.44

0.01595

-

pH 6.0, 40°C, recombinant His-tagged wild-type enzyme

743559

1.2.1.44

0.01636

-

isoform CCR21, at pH 6.3 and 30°C

763103

1.2.1.44

0.01973

-

pH 6.0, 40°C, recombinant His-tagged mutant F155Y

743559

1.2.1.44

0.02408

-

isoform CCR20, at pH 6.3 and 30°C

763103

1.2.1.44

0.0248

-

pH 6.0, 25°C, recombinant GST-tagged enzyme

742589

1.2.1.44

0.0316

-

100 mM sodium/potassium phosphate buffer pH 6.3, 250 mM NADPH

700489

1.2.1.44

0.03666

-

isoform CCR19, at pH 6.3 and 30°C

763103

1.2.1.44

0.0397

-

-

672472

1.2.1.44

0.05581

-

isoform CCR1, pH and temperature not specified in the publication

763599

1.2.1.44

0.0572

-

100 mM sodium/potassium phosphate buffer pH 6.3, 250 mM NADPH

700489

1.2.1.44

0.06

-

in 100 mM phosphate buffer pH 6.5, at 30°C

725147

1.2.1.44

0.07

-

pH 6.5, 30°C, mutant T154A

743501

1.2.1.44

0.1

-

pH 6.5, 30°C, wild-type enzyme

743501

1.2.1.44

0.1

-

-

288230

1.2.1.44

0.113

-

pH 6.5, 30°C, mutant Y154Y

743501

1.2.1.44

0.11608

-

isoform CCR2-1, pH and temperature not specified in the publication

763599

1.2.1.44

0.1165

-

at pH 6.0, temperature not specified in the publication

763766

1.2.1.44

0.1265

-

at pH 6.0, temperature not specified in the publication

763766

1.2.1.44

0.2086

-

recombinant isozyme CCR1, pH 6.0, 25°C

743447

1.2.1.44

0.2157

-

at pH 6.0, temperature not specified in the publication

763766

1.2.1.44

0.2743

-

at pH 6.0, temperature not specified in the publication

763766

1.2.1.44

0.377

-

pH 6.25, 37°C, recombinant His-tagged enzyme

743156

1.2.1.44

25 entries

1.3.1.117

0.097

-

pH 50, 35°C

745999

1.3.1.85

0.14

-

mutant enzyme V350A, pH and temperature not specified in the publication

739852

1.3.1.85

0.2

-

mutant enzyme V350G, pH and temperature not specified in the publication

739852

2.3.1.110

0.002

-

-

486132

2.3.1.110

0.0037

-

with tyramine as acceptor

486130

2.3.1.110

0.0067

-

+ tyramine

486126

2.3.1.110

0.017

-

-

486134

2.3.1.110

0.02

-

30°C, pH 8.5, recombinant enzyme

676598

2.3.1.110

0.0233

-

pH 8.5, 30°C

660244

2.3.1.110

0.057

-

with tyramine, pH 7.5, 30°C, recombinant AAT1

720789

2.3.1.110

0.157

-

with tryptamine, pH 7.5, 30°C, recombinant AAT1

720789

2.3.1.110

0.3

-

with phenethylamine, pH 7.5, 30°C, recombinant AAT1

720789

1.3.1.85

2 entries

2.3.1.110

9 entries

2.3.1.126

0.055

-

-

486247

2.3.1.133

0.0015

-

pH 7.0, 30°C, with 3-hydroxybenzoate

720787

2.3.1.133

0.0031

-

pH 7.0, 30°C, with 2,3-dihydroxybenzoate

720787

2.3.1.133

0.0043

-

pH 7.0, 30°C, with shikimate

720787

2.3.1.133

0.00813

-

pH 8.0, 37°C, recombinant GST-tagged enzyme, with shikimate

720173

2.3.1.133

0.0086

-

-

486280, 486282

2.3.1.133

0.00964

-

pH 8.0, 37°C, recombinant GST-tagged enzyme, with quinate

720173

2.3.1.133

0.0185

-

pH 7.0, 30°C, with 3-aminobenzoate

720787

2.3.1.133

0.022

-

pH 7.0, 30°C, with 3-hydroxyanthranilate

720787

2.3.1.133

0.024

-

-

486275

2.3.1.133

0.0295

-

pH 6.5, 30°C

758066

2.3.1.133

0.0378

-

pH 6.5, 30°C

758066

2.3.1.133

0.0601

-

pH 7.5, 37°C, with glycerol

720638

2.3.1.133

0.5

-

-

486283

2.3.1.133

0.6

-

-

486285

2.3.1.133

1.2

-

-

486279

2.3.1.133

8.13

-

with shikimate, pH 8.0, 37°C

720173

2.3.1.133

9.64

-

with quinate, pH 8.0, 37°C

720173

2.3.1.133

14.3

-

-

486281

2.3.1.140

0.0013

-

pH 7.0, 30°C, with 3-(3,4-dihydroxyphenyl)lactate, native RAS

720787

2.3.1.140

0.0018

-

pH 7.0, 30°C, with 3-(3,4-dihydroxyphenyl)lactate, recombinant RAS

720787

2.3.1.140

0.0032

-

with 3-(3,4-dihydroxyphenyl)lactate, pH 7.0, 30°C, crude recombinant His-tagged enzyme

720636

2.3.1.140

0.0047

-

pH 7.0, 30°C, with 3-(4-hydroxyphenyl)lactate, native RAS

720787

2.3.1.140

0.0048

-

with 3-(4-hydroxyphenyl)lactate, pH 7.0, 30°C, native crude enzyme

720636

2.3.1.140

0.0073

-

with 3-(3,4-dihydroxyphenyl)lactate, pH 7.0, 30°C, native crude enzyme

720636

2.3.1.140

0.0092

-

pH 7.0, 30°C, with 3-(4-hydroxyphenyl)lactate, recombinant RAS

720787

2.3.1.140

0.0094

-

with 3-(4-hydroxyphenyl)lactate, pH 7.0, 30°C, crude recombinant His-tagged enzyme

720636

2.3.1.140

0.0107

-

pH 7.0, 30°C, with D-phenyllactate, recombinant RAS

720787

2.3.1.140

0.014

-

with 3-(4-hydroxyphenyl)lactate, pH 7.5, 30°C, recombinant AAT1

720789

2.3.1.140

0.02

-

-

486321

2.3.1.140

0.0817

-

pH 7.0, 30°C, with D-tyrosine, recombinant RAS

720787

2.3.1.140

0.083

-

with shikimate, pH 7.5, 30°C, recombinant AAT1

720789

2.3.1.146

0.0009

-

isozyme PDSTS3

637803

2.3.1.146

0.0053

-

isozyme PDSTS2

637803

2.3.1.133

18 entries

2.3.1.140

13 entries

2.3.1.146

2 entries

2.3.1.153

0.19

-

with delphinidin 3,5-diglucoside as cosubstrate

16329

2.3.1.159

0.0136

-

pH 7.0, 30°C

736426

2.3.1.159

19.7

-

pH 7.0, 30°C

673581

2.3.1.188

0.01

-

pH 7.0, 30°C

700854

2.3.1.188

0.0143

-

pH 7.0, 30°C

700658

2.3.1.212

0.003

-

pH 8.0, 30°C

723451

2.3.1.212

0.01

-

pH 8.0, 30°C, recombinant wild-type enzyme

722174, 722633, 723330

2.3.1.212

0.01289

-

at pH 9.5 and 50°C

757487

2.3.1.212

0.013

-

pH 7.5, 35°C

757487

2.3.1.159

2 entries

2.3.1.188

2 entries

2.3.1.212

4 entries

2.3.1.215

0.0012

-

pH 6.5, 30°C

737034

2.3.1.219

0.0034

-

pH 7.5, 37°C, CURS2

719493

2.3.1.219

0.085

-

pH 8.0, 37°C, with cinnamoyl-diketide-N-acetylcysteaminyl-CoA

719850

2.3.1.219

0.089

-

pH 7.5, 37°C, CURS2

719493

2.3.1.219

0.189

-

pH 7.5, 37°C, CURS2

719493

2.3.1.219

4 entries

2.3.1.249

0.0106

-

pH 7.3, 30°C, recombinant His6-tagged enzyme

734888

2.3.1.302

0.16

-

pH 7, temperature not specified in the publication

762520

2.3.1.64

0.00074

-

-

487361

2.3.1.64

0.001

-

isoenzyme 1

487363

2.3.1.64

0.0015

-

-

487362

2.3.1.64

0.0016

-

isoenzyme 3

487363

2.3.1.64

0.0021

-

isoenzyme 2

487363

2.3.1.64

0.0021

-

recombinant enzyme

487363

2.3.1.74

0.0006

-

-

487463, 487456, 487460

2.3.1.74

0.0008

-

isozyme AI

487457

2.3.1.74

0.001

-

isozyme AII

487457

2.3.1.74

0.0015

-

-

487461

2.3.1.74

0.0016

-

-

487454

2.3.1.74

0.0017

-

-

487471

2.3.1.74

0.002

-

-

487474

2.3.1.74

0.0022

-

-

487467

2.3.1.74

0.0023

-

-

487466

2.3.1.74

0.0023

-

C169S/Q100E/K180Q triple mutant

487482

2.3.1.74

0.0025

-

wild-type enzyme

487482

2.3.1.74

0.00473

-

in the presence of 0.001 mM chalcone isomerase-like protein CHIL, at pH 7.5 and 30°C

757756

2.3.1.74

0.0049

-

pH 7.0, 35°C, wild-type enzyme

660170

2.3.1.74

0.00517

-

pH 8.0, 30°C

663042

2.3.1.74

0.0057

-

-

487464

2.3.1.74

0.0078

-

pH 7.0, 35°C, mutant enzyme L263M/F265Y/S338G

660170

2.3.1.74

0.0136

-

wild type enzyme, at pH 8.0, temperature not specified in the publication

756731

2.3.1.74

0.0142

-

mutant enzyme R105Q, at pH 8.0, temperature not specified in the publication

756731

2.3.1.74

0.01642

-

at pH 7.5 and 40°C

757487

2.3.1.74

0.01642

-

pH 7.5, 35°C

757487

2.3.1.74

0.0179

-

pH 7.0, 37°C

755721

2.3.1.74

0.0198

-

mutant enzyme Q82P/C198F, at pH 8.0, temperature not specified in the publication

756731

2.3.1.74

0.0213

-

mutant enzyme Q82P, at pH 8.0, temperature not specified in the publication

756731

2.3.1.74

0.0361

-

-

487479

2.3.1.74

0.0409

-

-

672501

2.3.1.74

0.048

-

37°C, pH 7.2

676378

2.3.1.74

0.0497

-

in the absence of chalcone isomerase-like protein CHIL, at pH 7.5 and 30°C

757756

2.3.1.95

0.002

-

-

487723

2.3.1.95

0.00287

-

pH 4.0, 30°C, recombinant STS

718636

2.3.1.95

0.00443

-

pH 4.0, 30°C, recombinant STS

718636

2.3.1.95

0.00856

-

pH 4.0, 30°C, recombinant STS

718636

2.3.1.95

0.011

-

-

487729

2.3.1.95

0.0119

-

pH 4.0, 30°C, recombinant STS

718636

2.3.1.95

0.016

-

P375G mutant enzyme

487726

2.3.1.95

0.022

-

-

487726

2.3.1.99

0.003

-

-

487783

2.3.1.99

0.008

-

-

486280

2.3.1.99

0.0295

-

pH 6.5, 30°C

758066

2.3.1.99

0.0378

-

pH 6.5, 30°C

758066

2.3.1.99

0.15

-

pH 6.6, 30°C, cosubstrate: quinate

486285

2.3.1.99

0.519

-

cosubstrate quinate, pH not specified in the publication, 30°C

756137

2.3.1.99

0.6

-

pH 6.6, 30°C, cosubstrate: shikimate

486285

2.3.1.99

10

-

-

486281

2.3.1.64

6 entries

2.3.1.74

27 entries

2.3.1.95

8 entries

2.3.1.99

8 entries

4.1.2.61

5.2

-

-

210668

References & Links

Literature References (218)

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Show Reference (218 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

595

9177055

3-Hydroxybenzoate:coenzyme A ligase and 4-coumarate:coenzyme A ligase from cultured cells of Centaurium erythraea

1997

Barillas, W.; Beerhues, L.

Planta

202

112-116

608

240682

Isoenzymes of p-coumarate:CoA ligase from cell suspension cultures of Glycine max

1975

Knobloch, K.H.; Hahlbrock, K.

Eur. J. Biochem.

52

311-320

3733

3355160

NAD(P)H-dependent 6-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract

1988

Ayabe, S.; Udagawa, A.; Furuya, T.

Arch. Biochem. Biophys.

261

458-462

16329

9363752

Anthocyanin 5-aromatic acyltransferase from Gentiana triflora

1997

Fujiwara, H.; Tanaka, Y.; Fukui, Y.; Nakao, M.; Ashikari, T.; Kusumi, T.

Eur. J. Biochem.

249

45-51

95079

3008651

In vitro inhibition of carrot chalcone synthase by 3'-nucleotidase: the role of the 3-phosphate group of malonyl-coenzyme A in flavonoid biosynthesis

1986

Hinderer, W.; Seitz, H.U.

Arch. Biochem. Biophys.

246

217-224

210668

10222033

4-Hydroxycinnamoyl-CoA hydratase/lyase (HCHL)-an enzyme of phenylpropanoid chain cleavage from Pseudomonas

1999

Mitra, A.; Kitamura, Y.; Gasson, M.J.; Narbad, A.; Parr, A.J.; Pyne, J.; Rhodes, M.J.C.; Sewter, C.; Walton, N.J.

Arch. Biochem. Biophys.

365

10-16

286350

-

Hydroxyphenylpyruvate reductase from cell suspension cultures of Coleus blumei Benth

1991

Häusler, E.; Petersen, M.; Alfermann, A.W.

Z. Naturforsch. C

46

371-376

286351

-

The biosynthesis of rosmarinic acid in suspension cultures of Coleus blumei

1994

Petersen, M.; Häusler E.; Meinhard J.; Karwatzki, B.; Gertlowski C.

Plant Cell Tissue Organ Cult.

38

171 - 179

288228

6365550

Purification and properties of cinnamoyl-CoA reductase and cinnamyl alcohol dehydrogenase from poplar stems (Populus X euramericana)

1984

Sarni, F.; Grand, C.; Boudet, A.M.

Eur. J. Biochem.

139

259-265

288230

7454

Enzymic synthesis of lignin precursors. Purification and properties of a cinnamoyl-CoA: NADPH reductase from cell suspension cultures of soybean (Glycine max)

1976

Wengenmayer, H.; Ebel, J.; Grisebach, H.

Eur. J. Biochem.

65

529-536

288233

7042334

Enzymic synthesis of lignin precursors. Comparison of cinnamoyl-CoA reductase and cinnamyl alcohol:NADP+ dehydrogenase from spruce (Picea abies L.) and soybean (Glycine max L.)

1981

Luderitz, T.; Grisebach, H.

Eur. J. Biochem.

119

115-124

288234

236926

Reduction of coenzyme A thioesters of cinnamic acids with an enzyme preparation from lignifying tissue of Forsythia

1975

Gross, G.G.; Kreiten, W.

FEBS Lett.

54

259-262

288235

-

Purification and characterization of cinnamoyl-CoA reductase from Eucalyptus gunnii

1995

Goffner, D.; Campbell, M.M.; Boudet, A.M.

Colloq. Inst. Natl. Rech. Agron.

69

329-330

486106

-

Hydroxycinnamoyl-coenzyme-A:tartronate hydroxycinnamoyltransferase in protein preparations from mung bean

1986

Strack, D.; Ruhoff, R.; Gräwe, W.

Phytochemistry

25

833-837

486126

-

The biosynthesis of feruloyltyramine in Nicotiana tabacum

1984

Negrel, J.; Martin, C.

Phytochemistry

23

2797-2801

486127

-

Partial purification of tyramine feruloyl transferase from TMV inoculated tobacco leaves

1989

Fleurence, J.; Negrel, J.

Phytochemistry

28

733-736

486128

11382813

Cloning and characterization of a hydroxycinnamoyl-CoA: tyramine N-(hydroxycinnamoyl)transferase induced in response to UV-C and wounding from Capsicum annuum

2001

Back, K.; Jang, S.M.; Lee, B.C.; Schmidt, A.; Strack, D.; Kim, K.M.

Plant Cell Physiol.

42

475-481

486130

10879473

Induction of N-hydroxycinnamoyltyramine synthesis and tyramine N-hydroxycinnamoyltransferase (THT) activity by wounding in maize leaves

2000

Ishihara, A.; Kawata, N.; Matsukawa, T.; Iwamura, H.

Biosci. Biotechnol. Biochem.

64

1025-1031

486131

11281128

L-Tyrosine beta-naphthylamide is a potent competitive inhibitor of tyramine N-(hydroxycinnamoyl)transferase in vitro

2001

Negrel, J.; Javelle, F.

Phytochemistry

56

523-527

486132

9288939

Purification, characterization and partial amino acid sequencing of hydroxycinnamoyl-CoA:tyramine N-(hydroxycinnamoyl)transferase from tobacco cell-suspension cultures

1997

Negrel, J.; Javelle, F.

Eur. J. Biochem.

247

1127-1135

486133

9933628

Cloning and expression of a potato cDNA encoding hydroxycinnamoyl-CoA:tyramine N-(hydroxycinnamoyl)transferase

1999

Schmidt, A.; Grimm, R.; Schmidt, J.; Scheel, D.; Strack, D.; Rosahl, S.

J. Biol. Chem.

274

4273-4280

486134

10467029

Purification, characterization, and immunolocalization of hydroxycinnamoyl-CoA: tyramine N-(hydroxycinnamoyl)transferase from opium poppy

1999

Yu, M.; Facchini, P.J.

Planta

209

33-44

486247

-

Hydroxycinnamic acid esters of isocitric acid: Accumulation and enzymatic synthesis in Amaranthus cruentus

1987

Strack, D.; Leicht, P.; Bokern, M.; Wray, V.; Grotjahn, L.

Phytochemistry

26

2919-2923

486275

-

Enzymatic synthesis of hydroxycinnamic acid esters of sugar acids and hydroaromatic acids by protein preparations from rye (Secale cereale) primary leaves

1987

Strack, D.; Keller, H.; Weissenböck, G.

J. Plant Physiol.

131

61-73

486278

-

Enzymic synthesis of hydroxycinnamic acid esters of glucaric acid and hydroaromatic acids from the respective 1-O-hydroxycinnamoylglucoside and hydroxycinnamoyl-Coenzyme A thioester as acyldonors with a protein preparation from Cestrum elegans leaves

1987

Strack, D.; Gross, W.; Heilemann, J.; Keller, H.; Ohm, S.

Z. Naturforsch. C

43c

32-36

486279

-

Partial purification and properties of p-hydroxycinnamoyl-CoA: shikimate-p-hydroxy-cinnamoyl transferase from higher plants

1980

Ulbrich, B.; Zenk, M.H.

Phytochemistry

19

1625-1629

486280

-

Partial purification and characterization of hydroxycinnamoyl CoA:transferase from apple and date fruits

1992

Lotfy, L.; Fleuriet, A.; Macheix, J.J.

Phytochemistry

31

767-772

486281

-

Hydroxycinnamoyl-CoA: transferases in higher plants. II. Characterization in Cichorium endivia and Raphanus sativus and comparison with other plants

1994

Lotfy, S.; Fleuriet, A.; Macheix, J.J.

Plant Physiol. Biochem.

32

355-363

486282

-

Inactivation and kinetic characterization of hydroxycinnamoyl-CoA:hydroaromatic acid O-hydroxycinnamoyltransferases from Cichorium endivia and Phoenix dactylifera

1995

Lotfy, S.

Plant Physiol. Biochem.

33

423-431

486283

12226354

Hydroxycinnamoyltransferases Involved in the accumulation of caffeic acid esters in gametophytes and sporophytes of Equisetum arvense

1996

Hohlfeld, M.; Veit, M.; Strack, D.

Plant Physiol.

111

1153-1159

486284

12428018

Differential production of meta hydroxylated phenylpropanoids in sweet basil peltate glandular trichomes and leaves is controlled by the activities of specific acyltransferases and hydroxylases

2002

Gang, D.R.; Beuerle, T.; Ullmann, P.; Werck-Reichhart, D.; Pichersky, E.

Plant Physiol.

130

1536-1544

486285

12381722

Purification, cloning, and properties of an acyltransferase controlling shikimate and quinate ester intermediates in phenylpropanoid metabolism

2003

Hoffmann, L.; Maury, S.; Martz, F.; Geoffroy, P.; Legrand, M.

J. Biol. Chem.

278

95-103

486313

16668786

Purification and properties of putrescine hydroxycinnamoyl transferase from tobacco (Nicotiana tabaccum) cell suspensions

1992

Negrel, J.; Paynot, M.; Javelle, F.

Plant Physiol.

98

1264-1269

486315

-

The biosynthesis of cinnamoylputrescines in callus tissue cultures of Nicotiana tabaccum

1989

Negrel, J.

Phytochemistry

28

477-481

486321

-

Characterization of rosmarinic acid synthase from cell cultures of Coleus blumei

1991

Petersen, M.S.

Phytochemistry

30

2877-2881

486330

9426598

Characterization and heterologous expression of hydroxycinnamoyl/benzoyl-CoA:anthranilate N-hydroxycinnamoyl/benzoyltransferase from elicited cell cultures of carnation, Dianthus caryophyllus L

1997

Yang, Q.; Reinhard, K.; Schiltz, E.; Matern, U.

Plant Mol. Biol.

35

777-789

486401

11054106

Specificities of functionally expressed chalcone and acridone synthases from Ruta graveolens

2000

Springob, K.; Lukacin, R.; Ernwein, C.; Groning, I.; Matern, U.

Eur. J. Biochem.

267

6552-6559

486402

11728463

Transformation of acridone synthase to chalcone synthase

2001

Lukacin, R.; Schreiner, S.; Matern, U.

FEBS Lett.

508

413-417

487360

-

The biosynthesis of coumaroylagmatine in barley seedlings

1981

Bird, C.R.; Smith, T.A.

Phytochemistry

20

2345-2346

487361

-

Agmatine coumaroyltransferase (barley seedlings)

1983

Bird, C.R.; Smith, T.A.

Methods Enzymol.

94

344-347

487362

-

Agmatine coumaroyltransferase from barley seedlings

1983

Bird, C.R.; Smith, T.A.

Phytochemistry

22

2401-2403

487363

12582168

A new class of N-hydroxycinnamoyltransferases. Purification, cloning, and expression of barley agmatine coumaroyltransferase (EC 2.3.1.64)

2003

Burhenne, K.; Kristensen, B.K.; Rasmussen, S.K.

J. Biol. Chem.

278

13919-13927

487450

7436427

Highly purified flavanone synthase from parsley catalyzes the formation of naringenin chalcone

1980

Heller, W.; Hahlbrock, K.

Arch. Biochem. Biophys.

200

617-619

487451

-

Isolation of a novel NADPH-dependent reductase which coacts with chalcone synthase in the biosynthesis of 6'-deoxychalcone

1988

Welle, R.; Grisebach, H.

FEBS Lett.

236

221-225

487453

-

Stilbene and chalcone synthases: Related enzymes with key functions in plant-specific pathways

1990

Schröder, J.; Schröder, G.

Z. Naturforsch. C

45c

1-8

487454

-

Preparation and assay of chalcone synthase from walnut tree tissue

1992

Claudot, A.C.; Drouet, A.

Phytochemistry

31

3377-3380

487455

2033084

The role of cysteines in polyketide synthases. Site-directed mutagenesis of resveratrol and chalcone synthases, two key enzymes in different plant-specific pathways

1991

Lanz, T.; Tropf, S.; Marner, F.J.; Schröder, J.; Schröder, G.

J. Biol. Chem.

266

9971-9976

487456

-

Biochemical and immunological characterization of chalcone synthase from rye leaves

1988

Peters, A.; Schneider-Poetsch, H.A.W.; Schwarz, H.; Weissenböck, G.

J. Plant Physiol.

133

178-182

487457

24226691

Chalcone synthases from spinach (Spinacia oleracea L.). I. Purification, peptide patterns, and immunological properties of different forms

1988

Beerhues, L.; Wiermann, R.

Planta

173

532-543

487459

-

Purification and properties of chalcone synthase from cell suspension cultures of soybean

1987

Welle, R.; Grisebach, H.

Z. Naturforsch. C

42c

1200-1206

487460

3087289

Isolation and characterization of buckwheat (Fagopyrum esculentum M.) chalcone synthase and its polyclonal antibodies

1986

Hrazdina, G.; Lifson, E.; Weeden, N.F.

Arch. Biochem. Biophys.

247

414-419

487461

3777940

The role of chalcone synthase in the regulation of flavonoid biosynthesis in developing oat primary leaves

1986

Knogge, W.; Schmelzer, E.; Weissenböck, G.

Arch. Biochem. Biophys.

250

364-372

487463

4015104

Chalcone synthase from cell suspension cultures of Daucus carota L

1985

Hinderer, W.; Seitz, H.U.

Arch. Biochem. Biophys.

240

265-272

487464

4044560

Purification and some properties of chalcone synthase from a carrot suspension culture induced for anthocyanin synthesis and preparation of its specific antiserum

1985

Ozeki, Y.; Sakano, K.; Komamine, A.; Tanaka, Y.; Noguchi, H.; Sankawa, U.; Suzuki, T.

J. Biochem.

98

9-17

487466

-

Chalcone synthase from cell suspension cultures of phaseolus vulgaris L.

1983

Whitehead, I.M.; Dixon, R.A.

Biochim. Biophys. Acta

747

298-303

487467

6853502

Substrate specificity of chalcone synthase from Petroselinum hortense. Formation of phloroglucinol derivatives from aliphatic substrates

1983

Schuz, R.; Heller, W.; Hahlbrock, K.

J. Biol. Chem.

258

6730-6734

487468

7396511

Chalcone synthesis with enzyme extracts from tulip anther tapetum using a biphasic enzyme assay

1980

Sutfeld, R.; Wiermann, R.

Arch. Biochem. Biophys.

201

64-72

487469

-

Purification of chalcone synthase from tulip anthers and comparison with the synthase from cosmos petals

1981

Sutfeld, R.; Wiermann, R.

Z. Naturforsch. C

36c

30-34

487470

-

Flavanone synthase from cell suspension cultures of Haplopappus gracilis and comparison with the synthase from parsely

1978

Saleh, N.A.M.; Fritsch, H.; Kreuzaler, F.; Grisebach, H.

Phytochemistry

17

183-186

487471

-

Characterization and development and localization of Flavanone synthase in tulip anthers

1978

Sutfeld, R.; Kehrel, B.; Wiermann, R.

Z. Naturforsch. C

33c

841-846

487472

-

Photoregulation of phenylalanine ammonia-lyase (PAL) and chalcone synthase (CHS) in the accumulation of anthocyanin in alpine and prairie ecotypes of Stellaria longipes under varied R/FR

2002

Alokam, S.; Li, Y.; Li, W.; Chinnappa, C.C.; Reid, D.M.

Physiol. Plant.

116

531-538

487474

9678580

A chalcone synthase with an unusual substrate preference is expressed in barley leaves in response to UV light and pathogen attack

1998

Christensen, A.B.; Gregersen, P.L.; Schroder, J.; Collinge, D.B.

Plant Mol. Biol.

37

849-857

487475

8799149

Duplication and functional divergence in the chalcone synthase gene family of Asteraceae: Evolution with substrate change and catalytic simplification

1996

Helariutta, Y.; Kotilainen, M.; Elomaa, P.; Kalkkinen, N.; Bremer, K.; Teeri, T.H.; Albert, V.A.

Proc. Natl. Acad. Sci. USA

93

9033-9038

487478

8225835

Structure, function, and regulation of the chalcone synthase

1993

Martin, C.R.

Int. Rev. Cytol.

147

233-284

487479

11112437

Enzymatic Formation of Unnatural Aromatic Polyketides by Chalcone Synthase

2000

Morita, H.; Takahashi, Y.; Noguchi, H.; Abe, I.

Biochem. Biophys. Res. Commun.

279

190-195

487481

10973790

Evidence for catalytic cysteine-histidine dyad in chalcone synthase

2000

Suh, D.Y.; Kagami, J.; Fukuma, K.; Sankawa, U.

Biochem. Biophys. Res. Commun.

275

725-730

487482

7713888

Reaction mechanisms of homodimeric plant polyketide synthases (stilbene and chalcone synthase). A single active site for the condensing reaction is sufficient for synthesis of stilbenes, chalcones, and 6'-deoxychalcones

1995

Tropf, S.; Kaercher, B.; Schroeder, G.; Schroeder, J.

J. Biol. Chem.

270

7922-7928

487483

10556516

Cross-reaction of chalcone synthase and stilbene synthase overexpressed in Escherichia coli

1999

Yamaguchi, T.; Kurosaki, F.; Suh, D.Y.; Sankawa, U.; Nishioka, M.; Akiyama, T.; Shibuya, M.; Ebizuka, Y.

FEBS Lett.

460

457-461

487484

11437245

Molecular and biochemical characterization of three aromatic polyketide synthase genes from Rubus idaeus

2001

Zheng, D.; Schroder, G.; Schroder, J.; Hrazdina, G.

Plant Mol. Biol.

46

1-15

487723

6427224

Purification and properties of a stilbene synthase from induced cell suspension cultures of peanut

1984

Schöppner, A.; Kindl, H.

J. Biol. Chem.

259

6806-6811

487726

-

Identification of amino acid residues important in the cyclization reactions of chalcone and stilbene synthases

2000

Suh, D.Y.; Fukuma, K.; Kagami, J.; Yamazaki, Y.; Shibuya, M.; Ebizuka, Y.; Sankawa, U.

Biochem. J.

350

229-235

487728

11714355

Stilbene compounds and stilbene synthase expression during ripening, wilting, and UV treatment in grape cv. Corvina

2001

Versari, A.; Parpinello, G.P.; Tornielli, G.B.; Ferrarini, R.; Giulivo, C.

J. Agric. Food Chem.

49

5531-5536

487729

11432743

Novel polyketides synthesized with a higher plant stilbene synthase

2001

Morita, H.; Noguchi, H.; Schroder, J.; Abe, I.

Eur. J. Biochem.

268

3759-3766

487730

12620343

Aromatic and pyrone polyketides synthesized by a stilbene synthase from Rheum tataricum

2003

Samappito, S.; Page, J.E.; Schmidt, J.; De-Eknamkul, W.; Kutchan, T.M.

Phytochemistry

62

313-323

487783

-

The enzymic conversion of hydroxycinnamic acids to p-coumarylquinic and chlorogenic acids in tomato fruits

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