Literature summary for 6.2.1.12 extracted from

Chen, J.Y.; Wen, P.F.; Kong, W.F.; Pan, Q.H.; Wan, S.B.; Huang, W.D.
Changes and subcellular localizations of the enzymes involved in phenylpropanoid metabolism during grape berry development (2006), J. Plant Physiol., 163, 115-127.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell wall	-	Vitis vinifera	5618	-
additional information	subcellular enzyme localization in berries	Vitis vinifera	-	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Vitis vinifera

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 4-coumarate + CoA	Vitis vinifera	-	AMP + diphosphate + 4-coumaroyl-CoA	-	?
additional information	Vitis vinifera	three key enzymes: phenylalanine ammonia-lyase, cinnamate-4-hydroxylase, and 4-coumarate-coenzyme A ligase, catalyzing the biosynthesis of these compounds during berry development, contents of gallic, protocatechuic, gentisic and caffeic acid all change drastically during berry development, while other compounds containing 4-hydroxybenzoic, vanillic, syringic, chlorogenic, 4-coumaric, ferulic and sinapic acid vary only slightly	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Vitis vinifera	-	cv. Cabernet Sauvignon	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
fruit	the enzyme is located predominantly in the secondarily thickened walls and the parenchyma cells of mesocarp vascular tissue, developmental changes in enzyme activity, overview	Vitis vinifera	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	changes in phenolic acids contents in fruits during development, overview	Vitis vinifera

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 4-coumarate + CoA	-	Vitis vinifera	AMP + diphosphate + 4-coumaroyl-CoA	-	?
additional information	three key enzymes: phenylalanine ammonia-lyase, cinnamate-4-hydroxylase, and 4-coumarate-coenzyme A ligase, catalyzing the biosynthesis of these compounds during berry development, contents of gallic, protocatechuic, gentisic and caffeic acid all change drastically during berry development, while other compounds containing 4-hydroxybenzoic, vanillic, syringic, chlorogenic, 4-coumaric, ferulic and sinapic acid vary only slightly	Vitis vinifera	?	-	?

Synonyms

Synonyms	Comment	Organism
4-Coumarate:coenzyme A ligase	-	Vitis vinifera

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
40	-	assay at	Vitis vinifera

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8.9	-	assay at	Vitis vinifera

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Vitis vinifera

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Release 2023.1 (January 2023)