Literature summary for 6.2.1.12 extracted from

Kang, K.; Park, M.; Park, S.; Kim, Y.S.; Lee, S.; Lee, S.G.; Back, K.
Production of plant-specific tyramine derivatives by dual expression of tyramine N-hydroxycinnamoyltransferase and 4-coumarate:coenzyme A ligase in Escherichia coli (2009), Biotechnol. Lett., 31, 1469-1475.

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Application

Application	Comment	Organism
synthesis	heterologous expression of biosynthetic genes encoding 4-coumarate:coenzyme A ligase and tyramine N-hydroxycinnamoyltransferase cloned from Arabidopsis thaliana and pepper, respectively. Simultaneous supplementation of substrates to the recombinant Escherichia coli results in the secretion of multiple tyramine derivatives into the medium at high yield: 4-coumaroyltyramine at 189 mg/l, feruloyltyramine at 135 mg/l, caffeoyltyramine at 40 mg/l. The recombinant Escherichia coli also produces, albeit at low concentration, a range of dopamine derivatives such as feruloyldopamine	Arabidopsis thaliana

Cloned(Commentary)

Cloned (Comment)	Organism
-	Arabidopsis thaliana
expression in together with tyramine N-hydroxycinnamoyltransferase in Escherichia coli	Arabidopsis thaliana

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	-	Arabidopsis thaliana	-	-

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	-	-	-

Synonyms

Synonyms	Comment	Organism
4-Coumarate:coenzyme A ligase	-	Arabidopsis thaliana
4CL	-	Arabidopsis thaliana

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Release 2023.1 (January 2023)