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Dabcyl-gammaPRPPAPVFY-Edans + H2O
Dabcyl-gammaPRPP + APVFY-Edans
human IgA1 with CH3 domain exchanged for that of human IgG1 + H2O
?
human immunoglobulin A1 + H2O
?
human immunoglobulin A1 + H2O
Fc fragment + Fab fragment
-
cleavage of the hinge region
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
human immunoglobulin A1 + H2O
immunoglobulin Fc + immunoglobulin Fab
-
cleavage of the hinge region
-
-
?
human monoclonal capsule-specific IgA + H2O
?
-
-
-
-
?
IgA2-IgA1 half hinge + H2O
?
Immunoglobulin A1 + H2O
?
immunoglobulin A1 + H2O
immunoglobulin A1 Fabalpha fragments + immunglobulin A1 Fcalpha
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
immunoglobulin IgA1 + H2O
effector domain of IgA1 + Fab determinants of IgA1
-
-
specific cleavage of hinge region. IgA1 bound to bacterial porin A is masked by the serogroup B polysaccharide capsule and less accessible to degradation. De novo synthesis of enzyme is required for degradation of porin-A-bound IgA1, specific cleavage of hinge region
-
?
IQADVPSVPSNNEEIY + H2O
IQADVP + SVPSNNEEIY
LPRPPAPVFSY + H2O
LPRP + PAPVFSY
NIVVAPPSPQANQAEEY + H2O
NIVVAPP + SPQANQAEEY
PPAPVY + H2O
Pro-Pro + APVY
-
-
-
?
PRPPAPVFSLDY + H2O
PRP + PAPVFSLDY
-
-
-
?
RAILPRPPAPVFSLDDY + H2O
RAILPRPP + APVFSLDDY
-
-
-
?
RAILPRPPAPVFY + H2O
RAILPRPP + APVFY
-
-
-
?
additional information
?
-
Dabcyl-gammaPRPPAPVFY-Edans + H2O
Dabcyl-gammaPRPP + APVFY-Edans
-
-
-
?
Dabcyl-gammaPRPPAPVFY-Edans + H2O
Dabcyl-gammaPRPP + APVFY-Edans
-
-
-
?
human IgA1 + H2O
?
-
-
-
?
human IgA1 + H2O
?
-
-
-
?
human IgA1 + H2O
?
-
-
cleavage of the peptide bond between amino acid residues 231-232 in each alpha chain
-
?
human IgA1 + H2O
?
-
-
-
?
human IgA1 + H2O
?
-
-
-
?
human IgA1 + H2O
?
-
-
-
?
human IgA1 + H2O
?
-
IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1
-
-
?
human IgA1 + H2O
?
-
human IgA1 possesses a unique hinge region composed of a repeated sequence rich in proline, serine and threonine, which are the specific cleavage sites of IgA1 protease
-
-
?
human IgA1 with CH3 domain exchanged for that of human IgG1 + H2O
?
-
-
-
-
?
human IgA1 with CH3 domain exchanged for that of human IgG1 + H2O
?
-
-
-
-
?
human IgA1 with CH3 domain exchanged for that of human IgG1 + H2O
?
-
-
-
-
?
human IgA1 with CH3 domain exchanged for that of human IgG1 + H2O
?
-
-
-
-
?
human immunoglobulin A1 + H2O
?
-
specific cleavage in the hinge region
-
-
?
human immunoglobulin A1 + H2O
?
-
specific cleavage in the hinge region, the C-terminal region of enzyme IgA1P is necessary for cleavage of IgA1
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
antibody with half of the IgA1 hinge region incorporated into the equivalent site in enzyme-resistant IgA2
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
antibody with half of the IgA1 hinge region incorporated into the equivalent site in enzyme-resistant IgA2
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
antibody with half of the IgA1 hinge region incorporated into the equivalent site in enzyme-resistant IgA2
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
antibody with half of the IgA1 hinge region incorporated into the equivalent site in enzyme-resistant IgA2
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
antibody with half of the IgA1 hinge region incorporated into the equivalent site in enzyme-resistant IgA2
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
antibody with half of the IgA1 hinge region incorporated into the equivalent site in enzyme-resistant IgA2
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
amino acid sequence requirements in the hinge of human immunoglobulin A1. Absolute requirement for Pro227 but not for Thr228, which can be replaced by Val. Enzyme from different strains may have different amino acid requirements for cleavage
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
amino acid sequence requirements in the hinge of human immunoglobulin A1. Absolute requirement for Pro227 but not for Thr228, which can be replaced by Val
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
amino acid sequence requirements in the hinge of human immunoglobulin A1. The enzyme shows no absolute requirement for either Pro or Thr at residue 227 to 228
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
-
?
Immunoglobulin A1 + H2O
?
A0A2X3VMP4, A3CMW3, F0I116, F0I1W6, F0I7T0, F0IUS4, F2BS82, F2C6A9, F2CCY5, F3SHU7, F3US40, F3UXX0 -
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
amino acid sequence requirements in the hinge of human immunoglobulin A1. Absolute requirement for Pro227 but not for Thr228, which can be replaced by Val
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
enzyme cleaves the alpha-chain at the Pro223-Ser224 bond
Fcalpha fragment + Fabalpha fragment
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
enzyme cleaves the alpha-chain at the Pro223-Ser224 bond
Fcalpha fragment + Fabalpha fragment
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
enzyme cleaves the alpha-chain at the Pro223-Ser224 bond
Fcalpha fragment + Fabalpha fragment
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
29648, 29651, 37001, 37008, 37009, 37011, 37012, 37013, 37015, 37017, 37022, 37024, 37030, 37031 -
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
cleavage products have MW of 30000 Da and 33000 Da
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
type 1 protease cleaves peptide bond Pro231-Ser232
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
type 2 protease cleaves peptide bond 235-236
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
type 3 protease cleaves peptide bond 237-238
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
Fsalpha1 fragment + Fcalpha1 fragment
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
alpha-chain
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
type 2 enzyme cleaves peptide bond 235-236, type 1 enzyme cleaves bond 237-238 in the alpha chain of IgA
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
cleavage of peptide bond Pro235-Thr236
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
the activity level of the type 2 enzyme is 10fold that observed for the type 1 enzyme
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
type 2 protease cleaves peptide bond 235-236
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
type 1 protease cleaves peptide bond 237-238
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
enzyme cleaves the alpha-chain at the Pro223-Ser224 bond
Fcalpha fragment + Fabalpha fragment
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
enzyme cleaves the alpha-chain at the Pro223-Ser224 bond
Fcalpha fragment + Fabalpha fragment
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
specific for human IgA1
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
enzyme cleaves the alpha-chain at the Pro223-Ser224 bond
Fcalpha fragment + Fabalpha fragment
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
enzyme cleaves the alpha-chain at the Pro223-Ser224 bond
Fcalpha fragment + Fabalpha fragment
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
Streptococcus mitior
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
cleavage products have MW of 30000 Da and 33000 Da
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
cleaves peptide bond Pro227-Thr228
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
cleaves peptide bond Pro227-Thr228
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
cleavage of peptide bond Pro235-Thr236
MW of the Fabalpha fragment is 28500 Da and the MW of the Fcalpha fragement is 33000 Da
?
IQADVPSVPSNNEEIY + H2O
IQADVP + SVPSNNEEIY
-
-
-
?
IQADVPSVPSNNEEIY + H2O
IQADVP + SVPSNNEEIY
-
-
-
?
LAMP1 + H2O
?
-
i.e. lysosome-associated membrane protein 1
-
?
LAMP1 + H2O
?
-
i.e. lysosome-associated membrane protein 1. The enzyme cleaves LAMP1 thereby accelerating its degradation rate in infected A431 human epidermoid carcinoma cells and resulting in the alteration of lysosomes
-
?
LAMP1 + H2O
?
-
i.e. lysosome-associated membrane protein 1. The enzyme cleaves LAMP1 thereby accelerating its degradation rate in infected A431 human epidermoid carcinoma cells and resulting in the alteration of lysosomes. Infection of T84 monolayers also results in IgA1 protease-mediated reduction of LAMP1
-
?
LAMP1 + H2O
?
-
LAMP1 is a major integral membrane glycoprotein of lysosomes and significantly reduces its steady-state levels in an infected cell. Pilus-induced Ca2+ flux triggers lysosome exocytosis and increases the amount of LAMP1 accessible to IgA1 protease
-
?
LPRPPAPVFSY + H2O
LPRP + PAPVFSY
-
-
-
?
LPRPPAPVFSY + H2O
LPRP + PAPVFSY
-
-
-
?
NIVVAPPSPQANQAEEY + H2O
NIVVAPP + SPQANQAEEY
-
-
-
?
NIVVAPPSPQANQAEEY + H2O
NIVVAPP + SPQANQAEEY
-
-
-
?
polymeric IgA + H2O
?
-
-
-
-
?
polymeric IgA + H2O
?
-
-
-
-
?
secretory IgA + H2O
?
-
-
-
-
?
secretory IgA + H2O
?
-
-
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 protease is an important factor of meningitis
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
retained antigen-binding activity of Fabalpha fragments of human monoclonal immunoglobulin A1 cleaved by IgA 1 protease opens the possibility that IgA1 protease-producing bacteria growing in the presence of IgA1 antibodies are coated with Fabalpha fragments. Such fragments may conceivably protect the microorganism from the immune system by blocking access of intact antibody molecules of the same or other isotypes and of immunocompetent cells
-
-
?
additional information
?
-
-
IgA1 protease of the Brazilian purpuric fever clone may contribute to the pathogenic potential of the virulent phenotype in Brazil
-
-
?
additional information
?
-
-
the enzyme cleaves myeloma IgA1 and secretory IgA but not myeloma IgA2, IgM, or IgG
-
-
?
additional information
?
-
-
enzyme requires 10 or more appropriate amino acids between the Fab and Fc region to maintain a minimum critical distance between the scissile bond and the start of the Fc
-
-
?
additional information
?
-
-
no substrate: human IgA1 with CH3 domain exchanged for that of human IgG1. CH3 domain residues E403, Q406, T409 influence sensitivity to cleavage by enzyme
-
-
?
additional information
?
-
-
all three forms of capsule-specific IgA show comparable susceptibilities to cleavage by bacterial IgA1 protease, demonstrating that secretory component does not prevent the proteolytic degradation of IgA1 by IgA1 protease. IgA1 cleavage results in formation of identical Fab fragments for each of the molecular forms, thereby abolishing the contribution of multivalence of polymeric IgA and secretory IgA
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
the enzyme could play a role in the selective host specificity of mucosal pathogens
-
-
?
additional information
?
-
-
the enzyme could play a role in the selective host specificity of mucosal pathogens
-
-
?
additional information
?
-
-
the enzyme could play a role in the selective host specificity of mucosal pathogens
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
the cleavage of IgA1 by gonococcal IgA1 protease within the lumen of the female lower genital tract is unlikely to be a significant factor in the pathogenesis of infections by Neisseria gonorrhoeae
-
-
?
additional information
?
-
-
enzyme requires 9 or more appropriate amino acids between the Fab and Fc region to maintain a minimum critical distance between the scissile bond and the start of the Fc
-
-
?
additional information
?
-
-
no substrate: human IgA1 with CH3 domain exchanged for that of human IgG1
-
-
?
additional information
?
-
-
IgA1 protease is an important factor of meningitis
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
enzyme requires 10 or more appropriate amino acids between the Fab and Fc region to maintain a minimum critical distance between the scissile bond and the start of the Fc
-
-
?
additional information
?
-
-
no substrate: human IgA1 with CH3 domain exchanged for that of human IgG1
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
Streptococcus mitior
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
no substrate: IgA2-IgA1 half hinge, an antibody with half of the IgA1 hinge region incorporated into the equivalent site in enzyme-resistant IgA2
-
-
?
additional information
?
-
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
-
potential impotance of IgA proteases as an ecological determinant in the oral cavity and their role as a determinant of pathogenesis of pathogenic bacteria whose portal of entry is the mucosal surface
-
-
?
additional information
?
-
-
no substrate: IgA2-IgA1 half hinge, an antibody with half of the IgA1 hinge region incorporated into the equivalent site in enzyme-resistant IgA2
-
-
?
additional information
?
-
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
-
IgA1 protease is an important factor of meningitis
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
the enzyme cleaves myeloma IgA1 and secretory IgA but not myeloma IgA2, IgM, or IgG
-
-
?
additional information
?
-
-
enzyme requires 12 or more appropriate amino acids between the Fab and Fc region to maintain a minimum critical distance between the scissile bond and the start of the Fc
-
-
?
additional information
?
-
-
polymeric and secretory IgA show comparable susceptibilities to functional inhibition by bacterial IgA1 protease cleavage, demonstrating that secretory component does not prevent the proteolytic degradation of IgA1 by IgA1 protease
-
-
?
additional information
?
-
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
enzyme requires 12 or more appropriate amino acids between the Fab and Fc region to maintain a minimum critical distance between the scissile bond and the start of the Fc
-
-
?
additional information
?
-
-
no substrate: IgA2-IgA1 half hinge, an antibody with half of the IgA1 hinge region incorporated into the equivalent site in enzyme-resistant IgA2
-
-
?
additional information
?
-
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
-
enzyme requires 12 or more appropriate amino acids between the Fab and Fc region to maintain a minimum critical distance between the scissile bond and the start of the Fc
-
-
?
additional information
?
-
-
no substrate: IgA2-IgA1 half hinge, an antibody with half of the IgA1 hinge region incorporated into the equivalent site in enzyme-resistant IgA2
-
-
?
additional information
?
-
-
the enzyme could play a role in the selective host specificity of mucosal pathogens
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
human IgA1 + H2O
?
-
IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1
-
-
?
human immunoglobulin A1 + H2O
?
-
specific cleavage in the hinge region
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
human immunoglobulin A1 + H2O
immunoglobulin Fc + immunoglobulin Fab
-
cleavage of the hinge region
-
-
?
Immunoglobulin A1 + H2O
?
immunoglobulin A1 + H2O
immunoglobulin A1 Fabalpha fragments + immunglobulin A1 Fcalpha
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
immunoglobulin IgA1 + H2O
effector domain of IgA1 + Fab determinants of IgA1
-
-
specific cleavage of hinge region. IgA1 bound to bacterial porin A is masked by the serogroup B polysaccharide capsule and less accessible to degradation. De novo synthesis of enzyme is required for degradation of porin-A-bound IgA1
-
?
additional information
?
-
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
-
?
Immunoglobulin A1 + H2O
?
A0A2X3VMP4, A3CMW3, F0I116, F0I1W6, F0I7T0, F0IUS4, F2BS82, F2C6A9, F2CCY5, F3SHU7, F3US40, F3UXX0 -
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
Immunoglobulin A1 + H2O
?
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
-
-
-
-
?
LAMP1 + H2O
?
-
i.e. lysosome-associated membrane protein 1. The enzyme cleaves LAMP1 thereby accelerating its degradation rate in infected A431 human epidermoid carcinoma cells and resulting in the alteration of lysosomes. Infection of T84 monolayers also results in IgA1 protease-mediated reduction of LAMP1
-
?
LAMP1 + H2O
?
-
LAMP1 is a major integral membrane glycoprotein of lysosomes and significantly reduces its steady-state levels in an infected cell. Pilus-induced Ca2+ flux triggers lysosome exocytosis and increases the amount of LAMP1 accessible to IgA1 protease
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 protease is an important factor of meningitis
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
retained antigen-binding activity of Fabalpha fragments of human monoclonal immunoglobulin A1 cleaved by IgA 1 protease opens the possibility that IgA1 protease-producing bacteria growing in the presence of IgA1 antibodies are coated with Fabalpha fragments. Such fragments may conceivably protect the microorganism from the immune system by blocking access of intact antibody molecules of the same or other isotypes and of immunocompetent cells
-
-
?
additional information
?
-
-
IgA1 protease of the Brazilian purpuric fever clone may contribute to the pathogenic potential of the virulent phenotype in Brazil
-
-
?
additional information
?
-
-
the enzyme cleaves myeloma IgA1 and secretory IgA but not myeloma IgA2, IgM, or IgG
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
the enzyme could play a role in the selective host specificity of mucosal pathogens
-
-
?
additional information
?
-
-
the enzyme could play a role in the selective host specificity of mucosal pathogens
-
-
?
additional information
?
-
-
the enzyme could play a role in the selective host specificity of mucosal pathogens
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
the cleavage of IgA1 by gonococcal IgA1 protease within the lumen of the female lower genital tract is unlikely to be a significant factor in the pathogenesis of infections by Neisseria gonorrhoeae
-
-
?
additional information
?
-
-
IgA1 protease is an important factor of meningitis
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
Streptococcus mitior
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
-
potential impotance of IgA proteases as an ecological determinant in the oral cavity and their role as a determinant of pathogenesis of pathogenic bacteria whose portal of entry is the mucosal surface
-
-
?
additional information
?
-
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
-
IgA1 protease is an important factor of meningitis
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
the enzyme cleaves myeloma IgA1 and secretory IgA but not myeloma IgA2, IgM, or IgG
-
-
?
additional information
?
-
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
-
IgA1 proteases are the principal etiologic agents of bacterial meningitis, gonorrhoea and periodontal disease
-
-
?
additional information
?
-
-
streptococcal immunglobulin A1 protease does not cleave porcine IgA
-
-
?
additional information
?
-
-
the enzyme could play a role in the selective host specificity of mucosal pathogens
-
-
?
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Bachovchin, W.W.; Plaut, A.G.; Flentke, G.R.; Lynch, M.; Kettner, C.A.
Inhibition of IgA1 proteinases from Neisseria gonorrhoeae and Hemophilus influenzae by peptide prolyl boronic acids
J. Biol. Chem.
265
3738-3743
1990
Haemophilus influenzae, Neisseria gonorrhoeae, Streptococcus sanguinis
brenda
Plaut, A.G.
The IgA1 proteases of pathogenic bacteria
Annu. Rev. Microbiol.
37
603-622
1983
Prevotella melaninogenica, Streptococcus pneumoniae, Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Streptococcus mitior, Streptococcus sanguinis
brenda
Grundy, F.J.; Plaut, A.; Wright, A.
Haemophilus influenzae immunoglobulin A1 protease genes: cloning by plasmid integration-excision, comparative analyses, and localization of secretion determinants
J. Bacteriol.
169
4442-4450
1987
Haemophilus influenzae
brenda
Grundy, F.J.; Plaut, A.; Wright, A.
Localization of the cleavage site specificity determinant of Haemophilus influenzae immunoglobulin A1 protease genes
Infect. Immun.
58
320-331
1990
Haemophilus influenzae
brenda
Plaut, A.G.
Production and isolation of neissereal IgA proteases
Methods Enzymol.
165
117-120
1988
Neisseria gonorrhoeae
brenda
Simpson, D.A.; Hausinger, R.P.; Mulks, M.H.
Purification, characterization, and comparison of the immunoglobulin A1 proteases of Neisseria gonorrhoeae
J. Bacteriol.
170
1866-1873
1988
Neisseria gonorrhoeae
brenda
Frandsen, E.V.G.; Reinholdt, J.; Kilian, M.
Enzymatic and antigenic characterization of immunoglobulin A1 proteases from Bacteroides and Capnocytophaga spp.
Infect. Immun.
55
631-638
1987
Prevotella buccae, Prevotella buccalis, Prevotella oralis, Prevotella veroralis, Capnocytophaga gingivalis, Capnocytophaga ochracea, Capnocytophaga sputigena
brenda
Kapatais-Zoumbos, K.; Chandler, D.K.F.; Barile, M.F.
Survey of immunoglobulin A protease activity among selected species of Ureaplasma and Mycoplasma: specificity for host immunoglobulin A
Infect. Immun.
47
704-709
1985
Mycoplasma genitalium, Mycoplasma hominis, Mycoplasma pneumoniae, Ureaplasma urealyticum
brenda
Mortensen, S.B.; Kilian, M.
Purification and characterization of an immunoglobulin A1 protease from Bacteroides melaninogenicus
Infect. Immun.
45
550-557
1984
Prevotella melaninogenica
brenda
Mortensen, S.B.; Kilian, M.
A rapid method for the detection and quantitation of IgA protease activity by macrobore gel-permeation chromatography
J. Chromatogr.
296
257-262
1984
Haemophilus influenzae
brenda
Koomey, J.M.; Falkow, S.
Nucleotide sequence homology between the immunoglobulin A1 protease genes of Neisseria gonorrhoeae, Neisseria meningitidis, and Haemophilus influenzae
Infect. Immun.
43
101-107
1984
Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis
brenda
Kilian, M.; Thomsen, B.
Antigenic heterogeneity of immunoglobulin A1 proteases from encapsulated and non-encapsulated Haemophilus influenzae
Infect. Immun.
42
126-132
1983
Haemophilus aegyptius, Haemophilus influenzae
brenda
Kilian, M.; Thomsen, B.; Petersen, T.E.; Bleeg, H.S.
Occurrence and nature of bacterial IgA proteases
Ann. N. Y. Acad. Sci.
409
612-624
1983
Porphyromonas asaccharolytica, Prevotella buccae, Porphyromonas gingivalis, Prevotella intermedia, Prevotella loescheii, Prevotella melaninogenica, Prevotella oris, Capnocytophaga gingivalis, Capnocytophaga ochracea, Capnocytophaga sputigena, Streptococcus pneumoniae, Gemella haemolysans, Haemophilus aegyptius, Haemophilus influenzae, Haemophilus parahaemolyticus, Neisseria gonorrhoeae, Neisseria meningitidis, Pseudomonas aeruginosa, Streptococcus mitior, Streptococcus sanguinis
brenda
Bricker, J.; Mulks, M.H.; Plaut, A.G.; Moxon, E.R.; Wright, A.
IgA1 proteases of Haemophilus influenzae: cloning and characterization in Escherichia coli K-12
Proc. Natl. Acad. Sci. USA
80
2681-2685
1983
Haemophilus influenzae
brenda
Koomey, J.M.; Gill, R.E.; Falkow, S.
Genetic and biochemical analysis of gonococcal IgA1 protease: cloning in Escherichia coli and construction of mutants of gonococci that fail to produce the activity
Proc. Natl. Acad. Sci. USA
79
7881-7885
1982
Neisseria gonorrhoeae
brenda
Kornfeld, S.J.; Plaut, A.G.
Secretory immunity and the bacterial IgA proteases
Rev. Infect. Dis.
3
521-534
1981
Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parahaemolyticus, Neisseria gonorrhoeae, Neisseria meningitidis, Streptococcus sanguinis
brenda
Kilian, M.; Mestecky, J.; Kulhavy, R.; Tomana, M.; Butler, W.T.
IgA1 proteases from Haemophilus influenzae, Streptococcus pneumoniae, Neisseria meningitidis, and Streptococcus sanguis: comparative immunochemical studies
J. Immunol.
124
2596-2600
1980
Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Streptococcus sanguinis
brenda
Kilian, M.; Mestecky, J.; Schrohenloher, R.E.
Pathogenic species of the genus Haemophilus and Streptococcus pneumoniae produce immunoglobulin A1 protease
Infect. Immun.
26
143-149
1979
Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis
brenda
Male, C.J.
Immunoglobulin A1 protease production by Haemophilus influenzae and Streptococcus pneumoniae
Infect. Immun.
26
254-261
1979
Streptococcus pneumoniae, Haemophilus influenzae
brenda
Blake, M.S.; Swanson, J.
Studies on gonococcus infection. XVI. Purification of Neisseria gonorrhoeae immunoglobulin A1 protease
Infect. Immun.
22
350-358
1978
Neisseria gonorrhoeae
brenda
Gilbert, J.V.; Plaut, A.G.; Fishman, Y.; Wright, A.
Cloning of the gene encoding streptococcal immunoglobulin A protease and its expression in Escherichia coli
Infect. Immun.
56
1961-1966
1988
Streptococcus sanguinis
brenda
Reinholt, J.
A method for titration of inhibiting antibodies to bacterial immunoglobulin A1 proteases in human serum and secretions
J. Immunol. Methods
191
39-48
1996
Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Streptococcus sanguinis
brenda
Hedges, S.R.; Mayo, M.S.; Kallman, L.; Mestecky, J.; Hook III, E.W.; Russell, M.W.
Evaluation of immunoglobulin A1 (IgA1) protease and IgA1 protease-inhibitory activity in human female genital infection with Neisseria gonorrhoeae
Infect. Immun.
66
5826-5832
1998
Neisseria gonorrhoeae
brenda
Lomholt, H.; Kilian, M.
Distinct antigenic and genetic properties of the immunoglobulin A1 protease produced by Haemophilus influenzae biogroup aegyptius associated with Brazilian purpuric fever in Brazil
Infect. Immun.
63
4389-4394
1995
Haemophilus influenzae
brenda
Frandsen, E.V.G.; Kjeldsen, M.; Kilian, M.
Inhibition of Prevotella and Capnocytophaga immunoglobulin A1 proteases by human serum
Clin. Diagn. Lab. Immunol.
4
458-464
1997
Prevotella buccae, Prevotella buccalis, Prevotella loescheii, Prevotella melaninogenica, Prevotella oris, Capnocytophaga ochracea, Prevotella denticola
brenda
Spooner, R.K.; Russell, W.C.; Thirkell, D.
Characterization of the immunoglobulin A protease of Ureaplasma urealyticum
Infect. Immun.
60
2544-2546
1992
Ureaplasma urealyticum
brenda
Poulsen, K.; Reinholdt, J.; Kilian, M.
Characterization of the Streptococcus pneumoniae immunoglobulin A1 protease gene (iga) and its translation product
Infect. Immun.
64
3957-3966
1996
Streptococcus pneumoniae, Streptococcus sanguinis
brenda
Poulsen, K.; Reinholdt, J.; Jespergaard, C.; Boye, K.; Brown, T.A.; Hauge, M.; Kilian, M.
A comprehensive genetic study of streptococcal immunoglobulin A1 proteases: evidence for recombination within and between species
Infect. Immun.
66
181-190
1998
Streptococcus mitis, Streptococcus oralis
brenda
Blake, M.S.; Eastby, C.
Studies on the gonococcal IgA1 protease II. Improved methods of enzyme purification and production of monoclonal antibodies to the enzyme
J. Immunol. Methods
144
215-221
1991
Neisseria gonorrhoeae, Neisseria meningitidis
brenda
Mansa, B.; Kilian, M.
Retained antigen-binding activity of Fab alpha fragments of human monoclonal immunoglobulin A1 (IgA1) cleaved by IgA1 protease
Infect. Immun.
52
171-174
1986
Haemophilus influenzae
brenda
Poulsen, K.; Hjorth, J.P.; Kilian, M.
Limited diversity of the immunoglobulin A1 protease gene (iga) among Haemophilus influenzae serotype b strains
Infect. Immun.
56
987-992
1988
Haemophilus influenzae
brenda
Tyler, B.M.; Cole, M.F.
Effect of IgA1 protease on the ability of secretory IgA1 antibodies to inhibit the adherence of Streptococcus mutans
Microbiol. Immunol.
42
503-508
1998
Streptococcus mutans
brenda
McLeod, D.T.; Croughan, M.J.; Brettle, R.P.; Calder, M.A.
Lack of immunoglobulin A1 protease production by Branhamella catarrhalis
Infect. Immun.
52
631-632
1986
no activity in Moraxella catarrhalis
brenda
Ayala, B.P.; Vasquez, B.; Clary, S.; Tainer, J.A.; Rodland, K.; So, M.
The pilus-induced Ca2+ flux triggers lysosome exocytosis and increases the amount of Lamp1 accessible to Neisseria IgA1 protease
Cell. Microbiol.
3
265-275
2001
Neisseria gonorrhoeae
brenda
Hopper, S.; Vasquez, B.; Merz, A.; Clary, S.; Wilbur, J.S.; So, M.
Effects of the immunoglobulin A1 protease on Neisseria gonorrhoeae trafficking across polarized T84 epithelial monolayers
Infect. Immun.
68
906-911
2000
Neisseria gonorrhoeae
brenda
Batten, M.R.; Senior, B.W.; Kilian, M.; Woof, J.M.
Amino acid sequence requirements in the hinge of human immunoglobulin A1 (IgA1) for cleavage by streptococcal IgA1 proteases
Infect. Immun.
71
1462-1469
2003
Streptococcus pneumoniae, Streptococcus mitis, Streptococcus oralis, Streptococcus sanguinis
brenda
McGillivary, G.; Smoot, L.M.; Actis, L.A.
Characterization of the IgA1 protease from the Brazilian purpuric fever strain F3031 of Haemophilus influenzae biogroup aegyptius
FEMS Microbiol. Lett.
250
229-236
2005
Haemophilus influenzae
brenda
Vidarsson, G.; Overbeeke, N.; Stemerding, A.M.; van den Dobbelsteen, G.; van Ulsen, P.; van der Ley, P.; Kilian, M.; van de Winkel, J.G.
Working mechanism of immunoglobulin A1 (IgA1) protease: cleavage of IgA1 antibody to Neisseria meningitidis PorA requires de novo synthesis of IgA1 Protease
Infect. Immun.
73
6721-6726
2005
Neisseria meningitidis
brenda
Bender, M.H.; Weiser, J.N.
The atypical amino-terminal LPNTG-containing domain of the pneumococcal human IgA1-specific protease is required for proper enzyme localization and function
Mol. Microbiol.
61
526-543
2006
Streptococcus pneumoniae
brenda
Romanello, V.; Marcacci, M.; Dal Molin, F.; Moschioni, M.; Censini, S.; Covacci, A.; Baritussio, A.G.; Montecucco, C.; Tonello, F.
Cloning, expression, purification, and characterization of Streptococcus pneumoniae IgA1 protease
Protein Expr. Purif.
45
142-149
2006
Streptococcus pneumoniae (Q59947), Streptococcus pneumoniae
brenda
Walker, S.G.; Carnu, O.I.; Tueter, G.; Ryan, M.E.
The immunoglobulin A1 proteinase from Streptococcus pneumoniae is inhibited by tetracycline compounds
FEMS Immunol. Med. Microbiol.
48
218-222
2006
Streptococcus pneumoniae
brenda
Senior, B.W.; Woof, J.M.
The influences of hinge length and composition on the susceptibility of human IgA to cleavage by diverse bacterial IgA1 proteases
J. Immunol.
174
7792-7799
2005
Streptococcus pneumoniae, Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Streptococcus mitis, Streptococcus oralis, Streptococcus sanguinis, Streptococcus sanguinis SK1
brenda
Senior, B.W.; Woof, J.M.
Sites in the CH3 domain of human IgA1 that influence sensitivity to bacterial IgA1 proteases
J. Immunol.
177
3913-3919
2006
Streptococcus pneumoniae, Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Streptococcus mitis, Streptococcus oralis, Streptococcus sanguinis
brenda
Adrian, P.V.; Bogaert, D.; Oprins, M.; Rapola, S.; Lahdenkari, M.; Kilpi, T.; de Groot, R.; Kaeyhty, H.; Hermans, P.W.
Development of antibodies against pneumococcal proteins alpha-enolase, immunoglobulin A1 protease, streptococcal lipoprotein rotamase A, and putative proteinase maturation protein A in relation to pneumococcal carriage and Otitis Media
Vaccine
22
2737-2742
2004
Streptococcus pneumoniae
brenda
de Paolis, F.; Beghetto, E.; Spadoni, A.; Montagnani, F.; Felici, F.; Oggioni, M.R.; Gargano, N.
Identification of a human immunodominant B-cell epitope within the immunoglobulin A1 protease of Streptococcus pneumoniae
BMC Microbiol.
7
113
2007
Streptococcus pneumoniae
brenda
Fernaays, M.M.; Lesse, A.J.; Cai, X.; Murphy, T.F.
Characterization of igaB, a second immunoglobulin A1 protease gene in nontypeable Haemophilus influenzae
Infect. Immun.
74
5860-5870
2006
Haemophilus influenzae
brenda
Fasching, C.E.; Grossman, T.; Corthesy, B.; Plaut, A.G.; Weiser, J.N.; Janoff, E.N.
Impact of the molecular form of immunoglobulin A on functional activity in defense against Streptococcus pneumoniae
Infect. Immun.
75
1801-1810
2007
Streptococcus pneumoniae, Haemophilus influenzae
brenda
Vitovski, S.; Sayers, J.R.
Relaxed cleavage specificity of an immunoglobulin A1 protease from Neisseria meningitidis
Infect. Immun.
75
2875-2885
2007
Neisseria meningitidis, Neisseria meningitidis NMB
brenda
Takenouchi-Ohkubo, N.; Mortensen, L.M.; Drasbek, K.R.; Kilian, M.; Poulsen, K.
Horizontal transfer of the immunoglobulin A1 protease gene (iga) from Streptococcus to Gemella haemolysans
Microbiology
152
2171-2180
2006
Streptococcus mitis (Q4U6L1), Streptococcus mitis (Q4U6L2), Gemella haemolysans (Q6TL30), Gemella haemolysans CCUG4815 (Q6TL30), Streptococcus mitis SK609 (Q4U6L2), Streptococcus mitis SK564 (Q4U6L1)
brenda
Lamm, M.E.; Emancipator, S.N.; Robinson, J.K.; Yamashita, M.; Fujioka, H.; Qiu, J.; Plaut, A.G.
Microbial IgA protease removes IgA immune complexes from mouse glomeruli in vivo: potential therapy for IgA nephropathy
Am. J. Pathol.
172
31-36
2008
Haemophilus influenzae
brenda
Zhang, A.; Mu, X.; Chen, B.; Liu, C.; Han, L.; Chen, H.; Jin, M.
Identification and characterization of IgA1 protease from Streptococcus suis
Vet. Microbiol.
140
171-175
2010
Streptococcus suis, Streptococcus suis 05ZYS
brenda
Xie, L.S.; Huang, J.; Qin, W.; Fan, J.M.
Immunoglobulin A1 protease: a new therapeutic candidate for immunoglobulin A nephropathy
Nephrology
15
584-586
2010
Streptococcus pneumoniae
brenda
Choudary, S.K.; Qiu, J.; Plaut, A.G.; Kritzer, J.A.
Versatile substrates and probes for IgA1 protease activity
ChemBioChem
14
2007-2012
2013
Streptococcus sanguinis (Q59986), Streptococcus sanguinis ATCC 10556 (Q59986)
brenda
Garner, A.L.; Fullagar, J.L.; Day, J.A.; Cohen, S.M.; Janda, K.D.
Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors
J. Am. Chem. Soc.
135
10014-10017
2013
Streptococcus pneumoniae
brenda
Murphy, T.F.; Kirkham, C.; Jones, M.M.; Sethi, S.; Kong, Y.; Pettigrew, M.M.
Expression of IgA proteases by Haemophilus influenzae in the respiratory tract of adults with chronic obstructive pulmonary disease
J. Infect. Dis.
212
1798-1805
2015
Haemophilus influenzae, Haemophilus influenzae 2019
brenda
Bek-Thomsen, M.; Poulsen, K.; Kilian, M.
Occurrence and evolution of the paralogous zinc metalloproteases IgA1 protease, ZmpB, ZmpC, and ZmpD in Streptococcus pneumoniae and related commensal species
mBio
3
e00303-12
2012
Streptococcus pneumoniae, Streptococcus oralis
brenda
Bek-Thomsen, M.; Poulsen, K.; Kilian, M.
Occurrence and evolution of the paralogous zinc metalloproteases IgA1 protease, ZmpB, ZmpC, and ZmpD in Streptococcus pneumoniae and related commensal species
mBio
3
00303-00312
2012
Gemella haemolysans, Streptococcus sanguinis
brenda
Bek-Thomsen, M.; Poulsen, K.; Kilian, M.
Occurrence and evolution of the paralogous zinc metalloproteases IgA1 protease, ZmpB, ZmpC, and ZmpD in Streptococcus pneumoniae and related commensal species
mBio
3
e00303
2012
Streptococcus mitis, Streptococcus mitis (A0A380KVU2), Streptococcus mitis (F9HE84), Streptococcus mitis (F9HP13), no activity in Streptococcus gordonii, Streptococcus infantis, Streptococcus infantis (E1M8Z5), Streptococcus infantis (F9PW76), no activity in Streptococcus parasanguinis, no activity in Streptococcus suis, no activity in Streptococcus cristatus, no activity in Streptococcus oligofermentans, no activity in Streptococcus australis, no activity in Streptococcus peroris, Streptococcus pseudopneumoniae, Streptococcus sanguinis (A0A2X3VMP4), Streptococcus sanguinis (A3CMW3), Streptococcus sanguinis (F0I116), Streptococcus sanguinis (F0I1W6), Streptococcus sanguinis (F0I7T0), Streptococcus sanguinis (F0IUS4), Streptococcus sanguinis (F2BS82), Streptococcus sanguinis (F2C6A9), Streptococcus sanguinis (F2CCY5), Streptococcus sanguinis (F3SHU7), Streptococcus sanguinis (F3US40), Streptococcus sanguinis (F3UXX0), Streptococcus oralis (P96466), Streptococcus pneumoniae (Q54875), Streptococcus pneumoniae (Q59947), Streptococcus pneumoniae (Q97QP7), Gemella haemolysans (Q6TL30), Streptococcus mitis SK1073 (F9HE84), Streptococcus pneumoniae PK81 (Q54875), Streptococcus sanguinis SK1087 (F3SHU7), Streptococcus sanguinis SK36 (A3CMW3), Streptococcus pseudopneumoniae IS7493, Streptococcus sanguinis SK330 (F2C6A9), Streptococcus mitis SK1080 (F9HP13), Streptococcus sanguinis SK355 (F3US40), Streptococcus sanguinis SK160 (F0IUS4), Streptococcus mitis NCTC 12261 (A0A380KVU2), Streptococcus oralis SK141 (P96466), Streptococcus sanguinis SK72 (F0I116), Streptococcus sanguinis SK72 (F0I1W6), Streptococcus infantis SK1302 (E1M8Z5), Streptococcus sanguinis SK49 (F3UXX0), Streptococcus infantis SK970 (F9PW76), Streptococcus sanguinis ATCC 29667 (A0A2X3VMP4), Streptococcus sanguinis SK408 (F2CCY5), Streptococcus sanguinis SK115 (F0I7T0), Streptococcus sanguinis SK1057 (F2BS82)
brenda
Shehaj, L.; Choudary, S.K.; Makwana, K.M.; Gallo, M.C.; Murphy, T.F.; Kritzer, J.A.
Small-molecule inhibitors of Haemophilus influenzae IgA1 protease
ACS Infect. Dis.
5
1129-1138
2019
Haemophilus influenzae NTHI
brenda
Gallo, M.C.; Kirkham, C.; Eng, S.; Bebawee, R.S.; Kong, Y.; Pettigrew, M.M.; Tettelin, H.; Murphy, T.F.
Changes in IgA protease expression are conferred by changes in genomes during persistent infection by nontypeable Haemophilus influenzae in chronic obstructive pulmonary disease
Infect. Immun.
86
e00313-18
2018
Haemophilus influenzae NTHI
brenda
Fu, L.; Zhao, J.; Lin, L.; Zhang, Q.; Xu, Z.; Han, L.; Xie, C.; Zhou, R.; Jin, M.; Zhang, A.
Characterization of IgA1 protease as a surface protective antigen of Streptococcus suis serotype 2
Microbes Infect.
18
285-289
2016
Streptococcus suis DAT1 (A0A0Z8E9X6), Streptococcus suis DAT1 SC-19 (A0A0Z8E9X6), Streptococcus suis DAT1 ZYS (A0A0Z8E9X6)
brenda
Kotelnikova, O.; Alliluev, A.; Zinchenko, A.; Zhigis, L.; Prokopenko, Y.; Nokel, E.; Razgulyaeva, O.; Zueva, V.; Tokarskaya, M.; Yastrebova, N.; Gordeeva, E.; Melikhova, T.; Kaliberda, E.; Rumsh, L.
Protective potency of recombinant meningococcal IgA1 protease and its structural derivatives upon animal invasion with meningococcal and pneumococcal infections
Microbes Infect.
21
336-340
2019
Neisseria meningitidis serogroup B, Neisseria meningitidis serogroup B B44/76
brenda
Chi, Y.C.; Rahkola, J.T.; Kendrick, A.A.; Holliday, M.J.; Paukovich, N.; Roberts, T.S.; Janoff, E.N.; Eisenmesser, E.Z.
Streptococcus pneumoniae IgA1 protease a metalloprotease that can catalyze in a split manner in vitro
Protein Sci.
26
600-610
2017
Streptococcus pneumoniae
brenda