Application | Comment | Organism |
---|---|---|
medicine | IgA1 protease may be an effective therapeutic candidate for IgAN by removing the mesangial deposited IgA1 in glomerular mesangium leading to immunoglobulin A nephropathy. The removal of IgA1 by IgA1 protease may separate the IgA1-containing immune complexes thereby eliminating its other components at the same time | Streptococcus pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
human IgA1 + H2O | Streptococcus pneumoniae | IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
human IgA1 + H2O | IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 | Streptococcus pneumoniae | ? | - |
? | |
human IgA1 + H2O | human IgA1 possesses a unique hinge region composed of a repeated sequence rich in proline, serine and threonine, which are the specific cleavage sites of IgA1 protease | Streptococcus pneumoniae | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IgA1 protease | - |
Streptococcus pneumoniae |
immunoglobulin A1 protease | - |
Streptococcus pneumoniae |