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Literature summary for 3.4.24.13 extracted from

  • Xie, L.S.; Huang, J.; Qin, W.; Fan, J.M.
    Immunoglobulin A1 protease: a new therapeutic candidate for immunoglobulin A nephropathy (2010), Nephrology, 15, 584-586.
    View publication on PubMed

Application

Application Comment Organism
medicine IgA1 protease may be an effective therapeutic candidate for IgAN by removing the mesangial deposited IgA1 in glomerular mesangium leading to immunoglobulin A nephropathy. The removal of IgA1 by IgA1 protease may separate the IgA1-containing immune complexes thereby eliminating its other components at the same time Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
human IgA1 + H2O Streptococcus pneumoniae IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 ?
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?

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human IgA1 + H2O IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1 Streptococcus pneumoniae ?
-
?
human IgA1 + H2O human IgA1 possesses a unique hinge region composed of a repeated sequence rich in proline, serine and threonine, which are the specific cleavage sites of IgA1 protease Streptococcus pneumoniae ?
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?

Synonyms

Synonyms Comment Organism
IgA1 protease
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Streptococcus pneumoniae
immunoglobulin A1 protease
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Streptococcus pneumoniae