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Literature summary for 3.4.24.13 extracted from

  • Plaut, A.G.
    The IgA1 proteases of pathogenic bacteria (1983), Annu. Rev. Microbiol., 37, 603-622.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
Neisseria gonorrhoeae
EDTA
-
Streptococcus pneumoniae
EDTA
-
Streptococcus sanguinis

Localization

Localization Comment Organism GeneOntology No. Textmining
periplasmic space recombinant enzyme produced in Escherichia coli is localized in the periplasmic space, a sequence linked to the carboxyl terminus of the iga gene but not present in the original clone is shown to be necessary to achieve normal secretion Haemophilus influenzae 42597
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
137000
-
x * 137000, SDS-PAGE Haemophilus influenzae

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae
-
-
-
Neisseria gonorrhoeae
-
-
-
Neisseria meningitidis
-
-
-
Prevotella melaninogenica
-
-
-
Streptococcus mitior
-
-
-
Streptococcus pneumoniae
-
-
-
Streptococcus sanguinis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
immunoglobulin A1 + H2O
-
Prevotella melaninogenica oligopeptides derived from immunoglobulin A1
-
?
immunoglobulin A1 + H2O
-
Streptococcus mitior oligopeptides derived from immunoglobulin A1
-
?
immunoglobulin A1 + H2O type 1 protease cleaves peptide bond Pro231-Ser232 Haemophilus influenzae oligopeptides derived from immunoglobulin A1
-
?
immunoglobulin A1 + H2O type 2 protease cleaves peptide bond 235-236 Haemophilus influenzae oligopeptides derived from immunoglobulin A1
-
?
immunoglobulin A1 + H2O type 2 protease cleaves peptide bond 235-236 Neisseria meningitidis oligopeptides derived from immunoglobulin A1
-
?
immunoglobulin A1 + H2O type 1 protease cleaves peptide bond 237-238 Neisseria meningitidis oligopeptides derived from immunoglobulin A1
-
?
immunoglobulin A1 + H2O type 3 protease cleaves peptide bond 237-238 Haemophilus influenzae oligopeptides derived from immunoglobulin A1
-
?
immunoglobulin A1 + H2O cleavage of peptide bond Pro235-Thr236 Neisseria gonorrhoeae oligopeptides derived from immunoglobulin A1
-
?
immunoglobulin A1 + H2O cleaves peptide bond Pro227-Thr228 Streptococcus pneumoniae oligopeptides derived from immunoglobulin A1
-
?
immunoglobulin A1 + H2O cleaves peptide bond Pro227-Thr228 Streptococcus sanguinis oligopeptides derived from immunoglobulin A1
-
?

Subunits

Subunits Comment Organism
?
-
Neisseria gonorrhoeae
? x * 137000, SDS-PAGE Haemophilus influenzae