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Literature summary for 3.4.24.13 extracted from

  • Fernaays, M.M.; Lesse, A.J.; Cai, X.; Murphy, T.F.
    Characterization of igaB, a second immunoglobulin A1 protease gene in nontypeable Haemophilus influenzae (2006), Infect. Immun., 74, 5860-5870.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information Blastx analysis shows that the igaB gene is homologous to the IgA1 protease genes of Neisseria gonorrhoeae and Neisseria meningitidis. The degree of homology of igaB to neisserial iga genes is greater than the homology of igaB to Haemophilus iga genes Haemophilus influenzae
additional information mutants that are deficient in iga, igaB, and both genes are constructed in Haemophilus influenzae strain 11P6H. Analysis of these mutants indicates that igaB is the primary mediator of IgA1 protease activity in this strain Haemophilus influenzae

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information reverse transcriptase PCR shows that igB is transcribed in Haemophilus influenza Haemophilus influenzae
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
IgA1 protease activity assays on 20 clinical isolates indicates that the igaB gene is associated with increased levels of IgA1 protease activity Haemophilus influenzae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Immunoglobulin A1 + H2O
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Haemophilus influenzae ?
-
?

Synonyms

Synonyms Comment Organism
IgA1 protease
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Haemophilus influenzae
igaB
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Haemophilus influenzae
igaB represents a second immunoglobulin A1 protease gene in nontypeable Haemophilus influenza Haemophilus influenzae