Application | Comment | Organism |
---|---|---|
medicine | systemically administered IgA protease is able to remove glomerular IgA immune complexes, both the antigen and antibody components, in a passive mouse model of IgA nephropathy. IgA protease decreases the amount of injected human IgA immune complexes deposited in the kidneys in vivo. The quantity of deposited complexes is reduced by digestion of IgA1 at a single site, the peptide bond between amino acid residues 231-232 in each alpha chain | Haemophilus influenzae |
Cloned (Comment) | Organism |
---|---|
expression in Haemophilis influenzae with His-tag. Protein is autoprocessed and secreted | Haemophilus influenzae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haemophilus influenzae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
human IgA1 + H2O | - |
Haemophilus influenzae | ? | cleavage of the peptide bond between amino acid residues 231-232 in each alpha chain | ? |