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Literature summary for 3.4.24.13 extracted from

  • Lamm, M.E.; Emancipator, S.N.; Robinson, J.K.; Yamashita, M.; Fujioka, H.; Qiu, J.; Plaut, A.G.
    Microbial IgA protease removes IgA immune complexes from mouse glomeruli in vivo: potential therapy for IgA nephropathy (2008), Am. J. Pathol., 172, 31-36.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine systemically administered IgA protease is able to remove glomerular IgA immune complexes, both the antigen and antibody components, in a passive mouse model of IgA nephropathy. IgA protease decreases the amount of injected human IgA immune complexes deposited in the kidneys in vivo. The quantity of deposited complexes is reduced by digestion of IgA1 at a single site, the peptide bond between amino acid residues 231-232 in each alpha chain Haemophilus influenzae

Cloned(Commentary)

Cloned (Comment) Organism
expression in Haemophilis influenzae with His-tag. Protein is autoprocessed and secreted Haemophilus influenzae

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human IgA1 + H2O
-
Haemophilus influenzae ? cleavage of the peptide bond between amino acid residues 231-232 in each alpha chain ?