Reference on EC 3.1.4.11 - phosphoinositide phospholipase C and Organism(s) Homo sapiens and UniProt Accession Q9P212
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
topREF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Banno, Y.; Nozawa, Y.
Characterization of partially purified phospholipase C from human platelet membranes
Biochem. J.
248
95-101
1987
Homo sapiens
Downes, C.P.; Michell, R.H.
The polyphosphoinositide phosphodiesterase of erythrocyte membranes
Biochem. J.
198
133-140
1981
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Maraldi, N.M.; Zini, N.; Santi, S.; Bavelloni, A.; Valmori, A.; Marmiroli, S.; Ognibene, A.
Phosphoinositidase C isozymes in SaOS-2 cells: immunocytochemical detection in nuclear and cytoplasmic compartments
Biol. Cell.
79
243-250
1993
Homo sapiens
Ginger, R.S.; Parker, P.J.
Expression, purification and characterisation of a functional phosphatidylinositol-specific phospholipase C-delta1 protein in Escherichia coli
Eur. J. Biochem.
210
155-160
1992
Homo sapiens
Carozzi, A.J.; Kriz, R.W.; Webster, C.; Parker, P.J.
Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily
Eur. J. Biochem.
210
521-529
1992
Homo sapiens
Dawson, R.M.C.; Hemington, N.; Irvine, R.F.
The inhibition of diacylglycerol-stimulated intracellular phospholipases by phospholipids with a phosphocholine-containing polar group. A possible physiological role for sphingomyelin
Biochem. J.
230
61-68
1985
Homo sapiens, Rattus norvegicus
Sies, W.; Lapetina, E.G.
Properties and distribution of phosphatidylinositol-specific phospholipase C in human and horse platelets
Biochim. Biophys. Acta
752
329-338
1983
Equus caballus, Homo sapiens
Mauco, G.; Chap, H.; Douste-Blazy, L.
Characterization and properties of a phosphatidylinositol phosphodiesterase (phospholipase C) from platelet cytosol
FEBS Lett.
100
367-370
1979
Homo sapiens
Roy, G.; Villar, L.M.; Lazaro, I.; Gonzalez, M.; Bootello, A.; Gonzalez-Porque, P.
Purification and properties of membrane and cytosolic phosphatidylinositol-specific phospholipase C from human spleen
J. Biol. Chem.
266
11495-11501
1991
Homo sapiens
Ochocka, A.M.; Pawelczyk, T.
Isozymes delta of phosphoinositide-specific phospholipase C and their role in signal transduction in the cell
Acta Biochim. Pol.
50
1097-1110
2003
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
Rhee, S.G.
Regulation of phosphoinositide-specific phospholipase C
Annu. Rev. Biochem.
70
281-312
2001
Homo sapiens, Mammalia, Rattus norvegicus, Rattus norvegicus PLC-delta1
Rodriguez, R.; Matsuda, M.; Storey, A.; Katan, M.
Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling
Biochem. J.
374
269-280
2003
Homo sapiens
Caricasole, A.; Sala, C.; Roncarati, R.; Formenti, E.; Terstappen, G.C.
Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLCbeta1)
Biochim. Biophys. Acta
1517
63-72
2000
Homo sapiens (Q9NQ66), Homo sapiens
Rossi, M.A.; Dianzani, M.U.
Action of 2-nonenal and 4-hydroxynonenal on phosphoinositide-specific phospholipase C in undifferentiated and DMSO-differentiated HL-60 cells
Cell Biochem. Funct.
18
209-214
2000
Homo sapiens
Zhang, W.; Neer, E.J.
Reassembly of phospholipase C-b2 from separated domains: analysis of basal and G protein-stimulated activities
J. Biol. Chem.
276
2503-2508
2001
Homo sapiens (Q00722)
Rodriguez, R.; Matsuda, M.; Perisic, O.; Bravo, J.; Paul, A.; Jones, N.P.; Light, Y.; Swann, K.; Williams, R.L.; Katan, M.
Tyrosine residues in phospholipase Cgamma2 essential for the enzyme function in B-cell signaling
J. Biol. Chem.
276
47982-47992
2001
Homo sapiens (P16885), Homo sapiens
Rebecchi, M.J.; Pentyala, S.N.
Structure, function, and control of phosphoinositide-specific phospholipase C
Physiol. Rev.
80
1291-1335
2000
Arabidopsis thaliana, Saccharomyces cerevisiae, Dictyostelium discoideum, Drosophila sp. (in: flies), Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae PLC1p
Hwang, J.I.; Oh, Y.S.; Shin, K.J.; Kim, H.; Ryu, S.H.; Suh, P.G.
Molecular cloning and characterization of a novel phospholipase C, PLC-eta
Biochem. J.
389
181-186
2005
Mus musculus (Q4KWH5), Mus musculus, Homo sapiens (Q4KWH8), Homo sapiens
Lukinovic-Skudar, V.; Donlagic, L.; Banfic, H.; Visnjic, D.
Nuclear phospholipase C-beta1b activation during G2/M and late G1 phase in nocodazole-synchronized HL-60 cells
Biochim. Biophys. Acta
1733
148-156
2005
Homo sapiens
vom Dorp, F.; Sari, A.Y.; Sanders, H.; Keiper, M.; Oude Weernink, P.A.; Jakobs, K.H.; Schmidt, M.
Inhibition of phospholipase C-epsilon by Gi-coupled receptors
Cell. Signal.
16
921-928
2004
Homo sapiens
Peng, H.H.; Hodgson, L.; Henderson, A.J.; Dong, C.
Involvement of phospholipase C signaling in melanoma cell-induced endothelial junction disassembly
Front. Biosci.
10
1597-1606
2005
Homo sapiens
Martelli, A.M.; Fiume, R.; Faenza, I.; Tabellini, G.; Evangelista, C.; Bortul, R.; Follo, M.Y.; Fala, F.; Cocco, L.
Nuclear phosphoinositide specific phospholipase C (PI-PLC)-beta 1: a central intermediary in nuclear lipid-dependent signal transduction
Histol. Histopathol.
20
1251-1260
2005
Cricetulus griseus, Homo sapiens, Mus musculus, Rattus norvegicus
Stewart, A.J.; Mukherjee, J.; Roberts, S.J.; Lester, D.; Farquharson, C.
Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes
Int. J. Mol. Med.
15
117-121
2005
Homo sapiens, Mus musculus
Piechulek, T.; Rehlen, T.; Walliser, C.; Vatter, P.; Moepps, B.; Gierschik, P.
Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases
J. Biol. Chem.
280
38923-38931
2005
Homo sapiens
Hou, C.; Kirchner, T.; Singer, M.; Matheis, M.; Argentieri, D.; Cavender, D.
In vivo activity of a phospholipase C inhibitor, 1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione (U73122), in acute and chronic inflammatory reactions
J. Pharmacol. Exp. Ther.
309
697-704
2004
Homo sapiens
Kim, Y.J.; Sekiya, F.; Poulin, B.; Bae, Y.S.; Rhee, S.G.
Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2
Mol. Cell. Biol.
24
9986-9999
2004
Homo sapiens, Homo sapiens (P16885), Mus musculus, Mus musculus (Q8CIH5)
Cai, Y.; Stafford, L.J.; Bryan, B.A.; Mitchell, D.; Liu, M.
G-protein-activated phospholipase C-beta, new partners for cell polarity proteins Par3 and Par6
Oncogene
24
4293-4300
2005
Homo sapiens, Rattus norvegicus
Sorli, S.C.; Bunney, T.D.; Sugden, P.H.; Paterson, H.F.; Katan, M.
Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants
Oncogene
24
90-100
2005
Homo sapiens, Homo sapiens (Q9P212)
Diaz Anel, A.M.
Phospholipase C beta3 is a key component in the Gbetagamma/PKCeta/PKD-mediated regulation of trans-Golgi network to plasma membrane transport
Biochem. J.
406
157-165
2007
Homo sapiens (Q01970)
Lukinovic-Skudar, V.; Matkovic, K.; Banfic, H.; Visnjic, D.
Two waves of the nuclear phospholipase C activity in serum-stimulated HL-60 cells during G(1) phase of the cell cycle
Biochim. Biophys. Acta
1771
514-521
2007
Homo sapiens
Bertagnolo, V.; Benedusi, M.; Brugnoli, F.; Lanuti, P.; Marchisio, M.; Querzoli, P.; Capitani, S.
Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells
Carcinogenesis
28
1638-1645
2007
Homo sapiens (Q00722), Homo sapiens
Brugnoli, F.; Bavelloni, A.; Benedusi, M.; Capitani, S.; Bertagnolo, V.
PLC-beta2 activity on actin-associated polyphosphoinositides promotes migration of differentiating tumoral myeloid precursors
Cell. Signal.
19
1701-1712
2007
Homo sapiens (Q00722)
Liu, X.; Zhao, Q.; Araki, S.; Zhang, S.; Miao, J.
Contrasting effects of phosphatidylinositol- and phosphatidylcholine-specific phospholipase C on apoptosis in cultured endothelial cells
Endothelium
13
205-211
2006
Homo sapiens
Faenza, I.; Bregoli, L.; Ramazzotti, G.; Gaboardi, G.; Follo, M.Y.; Mongiorgi, S.; Billi, A.M.; Manzoli, L.; Martelli, A.M.; Cocco, L.
Nuclear phospholipase C beta1 and cellular differentiation
Front. Biosci.
13
2452-2463
2008
Homo sapiens (Q01970), Homo sapiens (Q9NQ66), Mus musculus (Q9Z1B3)
Alvarez-Breckenridge, C.A.; Waite, K.A.; Eng, C.
PTEN regulates phospholipase D and phospholipase C
Hum. Mol. Genet.
16
1157-1163
2007
Homo sapiens
Stewart, A.J.; Morgan, K.; Farquharson, C.; Millar, R.P.
Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues
Neuroendocrinology
86
243-248
2007
Chlorocebus aethiops, Homo sapiens, Rattus norvegicus
Ho, K.K.; Mann, D.J.
Nuclear signaling through phospholipase C and phosphatidylinositol 4,5-bisphosphate
Signal Transduction
6
92-100
2006
Homo sapiens, Mus musculus (Q8R3B1), Mus musculus (Q9Z1B3)
-
Kim, K.Y.; Bang, S.; Han, S.; Nguyen, Y.H.; Kang, T.M.; Kang, K.W.; Hwang, S.W.
TRP-independent inhibition of the phospholipase C pathway by natural sensory ligands
Biochem. Biophys. Res. Commun.
370
295-300
2008
Homo sapiens
Sala, G.; Dituri, F.; Raimondi, C.; Previdi, S.; Maffucci, T.; Mazzoletti, M.; Rossi, C.; Iezzi, M.; Lattanzio, R.; Piantelli, M.; Iacobelli, S.; Broggini, M.; Falasca, M.
Phospholipase Cgamma1 is required for metastasis development and progression
Cancer Res.
68
10187-10196
2008
Homo sapiens
Ochocka, A.M.; Grden, M.; Sakowicz-Burkiewicz, M.; Szutowicz, A.; Pawelczyk, T.
Regulation of phospholipase C-delta1 by ARGHAP6, a GTPase-activating protein for RhoA: possible role for enhanced activity of phospholipase C in hypertension
Int. J. Biochem. Cell Biol.
40
2264-2273
2008
Homo sapiens (P51178), Homo sapiens
Loreto, C.; Carnazza, M.L.; Cardile, V.; Libra, M.; Lombardo, L.; Malaponte, G.; Martinez, G.; Musumeci, G.; Papa, V.; Cocco, L.
Mineral fiber-mediated activation of phosphoinositide-specific phospholipase c in human bronchoalveolar carcinoma-derived alveolar epithelial A549 cells
Int. J. Oncol.
34
371-376
2009
Homo sapiens
Harita, Y.; Kurihara, H.; Kosako, H.; Tezuka, T.; Sekine, T.; Igarashi, T.; Ohsawa, I.; Ohta, S.; Hattori, S.
Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-[gamma]1
J. Biol. Chem.
284
8951-8962
2009
Homo sapiens (P19174)
Hao, J.J.; Liu, Y.; Kruhlak, M.; Debell, K.E.; Rellahan, B.L.; Shaw, S.
Phospholipase C-mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane
J. Cell Biol.
184
451-462
2009
Homo sapiens
Follo, M.Y.; Finelli, C.; Clissa, C.; Mongiorgi, S.; Bosi, C.; Martinelli, G.; Baccarani, M.; Manzoli, L.; Martelli, A.M.; Cocco, L.
Phosphoinositide-phospholipase C beta1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia
J. Clin. Oncol.
27
782-790
2009
Homo sapiens (P19174), Homo sapiens (Q15147), Homo sapiens (Q9NQ66), Homo sapiens
Nelson, C.P.; Nahorski, S.R.; Challiss, R.A.
Temporal profiling of changes in phosphatidylinositol 4,5-bisphosphate, inositol 1,4,5-trisphosphate and diacylglycerol allows comprehensive analysis of phospholipase C-initiated signalling in single neurons
J. Neurochem.
107
602-615
2008
Homo sapiens, Rattus norvegicus
Thyagarajan, B.; Benn, B.S.; Christakos, S.; Rohacs, T.
Phospholipase C-mediated regulation of transient receptor potential vanilloid 6 channels: implications in active intestinal Ca2+ transport
Mol. Pharmacol.
75
608-616
2009
Homo sapiens
Lee, J.S.; Yoo, H.; Suh, Y.G.; Jung, J.K.; Kim, J.
Structure-activity relationship of pentacylic triterpene esters from Uncaria rhynchophylla as inhibitors of phospholipase Cgamma1
Planta Med.
74
1481-1487
2008
Homo sapiens, Mus musculus
Fiume, R.; Teti, G.; Faenza, I.; Cocco, L.
Phosphoinositide-specific phospholipase C beta1 signal transduction in the nucleus
Methods Mol. Biol.
645
143-164
2010
Rattus norvegicus (P10687), Homo sapiens (Q9NQ66), Homo sapiens, Mus musculus (Q9Z1B3)
Fukami, K.; Inanobe, S.; Kanemaru, K.; Nakamura, Y.
Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance
Prog. Lipid Res.
49
429-437
2010
Homo sapiens, Mus musculus, Rattus norvegicus
van Veen, M.; Mans, L.A.; Matas-Rico, E.; van Pelt, J.; Perrakis, A.; Moolenaar, W.H.; Haramis, A.G.
Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish
Int. J. Biochem. Cell Biol.
94
71-78
2018
Danio rerio (E9QG52), Danio rerio (X1WHY1), Homo sapiens (Q8WTR4)
Smrcka, A.V.
Regulation of phosphatidylinositol-specific phospholipase C at the nuclear envelope in cardiac myocytes
J. Cardiovasc. Pharmacol.
65
203-210
2015
Homo sapiens
Di Raimo, T.; Leopizzi, M.; Mangino, G.; Rocca, C.D.; Businaro, R.; Longo, L.; Lo Vasco, V.R.
Different expression and subcellular localization of phosphoinositide-specific phospholipase C enzymes in differently polarized macrophages
J. Cell Commun. Signal.
10
283-293
2016
Homo sapiens
Fais, P.; Leopizzi, M.; Di Maio, V.; Longo, L.; Della Rocca, C.; Tagliaro, F.; Bortolotti, F.; Lo Vasco, V.R.
Phosphoinositide-specific phospholipase C in normal human liver and in alcohol abuse
J. Cell. Biochem.
120
7907-7917
2018
Homo sapiens
Cocco, L.; Follo, M.Y.; Manzoli, L.; Suh, P.G.
Phosphoinositide-specific phospholipase C in health and disease
J. Lipid Res.
56
1853-1860
2015
Homo sapiens
