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Literature summary for 3.1.4.11 extracted from

  • Rebecchi, M.J.; Pentyala, S.N.
    Structure, function, and control of phosphoinositide-specific phospholipase C (2000), Physiol. Rev., 80, 1291-1335.
    View publication on PubMed
Search for more literature for 3.1.4.11

Activating Compound

Activating Compound Comment Organism Structure
G protein betagamma may be the main positive regulator of DdPLC Dictyostelium discoideum

Application

Application Comment Organism
medicine PLC-gamma1 may permit the progression of some tumors Homo sapiens

Protein Variants

Protein Variants Comment Organism
C1094S NorpA mutant with slowed activation and deactivation Drosophila sp. (in: flies)
additional information DdPLC null mutant fails to aggregate at low cell densities Dictyostelium discoideum
additional information flies lacking NorpA are blind Drosophila sp. (in: flies)
additional information mutant mice lacking PLC-beta1: sudden death due to epileptic-like seizures, mutant mice lacking PLC-beta2 and PLC-beta4: phenotypes, homozygous disruption of the PLC-beta3 gene is lethal by day 2.5 of development, mutant mice with disruption of one or both copies of the PLC-gamma1 gene, homozygous mice die by embryonic day 9 Mus musculus
additional information PLC1 deletion mutant with slowed growth Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+-dependent Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
91000
-
 x * 91000 Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Arabidopsis thaliana AtPLC1S is involved in stress responses, AtPLC2 not ?
-
 ?
additional information Rattus norvegicus cellular signaling ?
-
 ?
additional information Homo sapiens cellular signaling, regulation of PLC activity ?
-
 ?
additional information Drosophila sp. (in: flies) PLC plays a key role in photoreceptor response ?
-
 ?
additional information Mus musculus PLC-beta1 is nessecary for the development and/or maintenance of brain inhibitory pathways, the retinal variants of PLC-beta4 function in signal processing within the retina, PLC-beta3 plays a role in the early development ?
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
 AtPLC1S, AtPLC2, delta-related isotypes
-
Dictyostelium discoideum
-
 DdPLC, homolog to mammalian PLC-delta
-
Drosophila sp. (in: flies)
-
 NorpA, PLC-21
-
Homo sapiens
-
-
-
Mus musculus
-
 PLC-beta
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
 PLC1p
-
Saccharomyces cerevisiae PLC1p
-
 PLC1p
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein PLC-gamma1, phosphorylation sites: Tyr-771 and Tyr-783 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte adult brain, PLC-delta1 is concentrated in astroglial cells, much lower levels in neurons Rattus norvegicus
-
brain adult, PLC-gamma1 is diffusely distributed, expression pattern of PLC-gamma1 and PLC-delta1 during development, expression pattern of PLC-gamma2 Rattus norvegicus
-
embryo high PLC-beta3 expression in very early embryos Mus musculus
-
embryo PLC-gamma homolog, widely distributed in the embryo Drosophila sp. (in: flies)
-
eye NorpA type I, eye-specific Drosophila sp. (in: flies)
-
flower constitutive expression of AtPLC2 in vegetative and floral tissues Arabidopsis thaliana
-
head PLC-21 type I, head-specific Drosophila sp. (in: flies)
-
hippocampus PLC-beta1 is prominently expressed in hippocampal pyramidal cells Mus musculus
-
leaf AtPLC1S is concentrated in shoot and leaf Arabidopsis thaliana
-
additional information PLC-beta2 is highly expressed in cells of the immune system Mus musculus
-
neuron adult brain, much lower levels of PLC-delta1 in neurons than in astroglial cells Rattus norvegicus
-
oocyte high PLC-beta3 expression in unfertilized oocytes Mus musculus
-
retina PLC-beta4 Mus musculus
-
shoot AtPLC1S is concentrated in shoot and leaf Arabidopsis thaliana
-
vegetative cell constitutive expression of AtPLC2 in vegetative and floral tissues Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Drosophila sp. (in: flies) 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Mus musculus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Arabidopsis thaliana 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Dictyostelium discoideum 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O preferred substrate Saccharomyces cerevisiae 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O domain structures of PLC-beta, -gamma and -delta isoenzymes Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O domain structures of PLC–beta, -gamma and -delta isoenzymes Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O preferred substrate Saccharomyces cerevisiae PLC1p 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
additional information AtPLC1S is involved in stress responses, AtPLC2 not Arabidopsis thaliana ?
-
 ?
additional information cellular signaling Rattus norvegicus ?
-
 ?
additional information cellular signaling, regulation of PLC activity Homo sapiens ?
-
 ?
additional information PLC plays a key role in photoreceptor response Drosophila sp. (in: flies) ?
-
 ?
additional information PLC-beta1 is nessecary for the development and/or maintenance of brain inhibitory pathways, the retinal variants of PLC-beta4 function in signal processing within the retina, PLC-beta3 plays a role in the early development Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 91000 Dictyostelium discoideum

Synonyms

Synonyms Comment Organism
NorpA Drosophila sp. PLC-beta homolog Drosophila sp. (in: flies)
PLC-21 Drosophila sp. PLC-beta homolog Drosophila sp. (in: flies)