Application | Comment | Organism |
---|---|---|
medicine | PLC-beta2 may constitute a molecular marker of breast tumor cells able to monitor the progression to invasive cancers and a target for novel therapeutic breast cancer strategies | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | PLC-beta2 may improve some malignant characteristics of tumor cells, like motility and invasion capability, but it fails to induce tumorigenesis in nontransformed breast-derived cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q00722 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | compared with the G0/G1 phases of the cell cycle, the cells in S/G2/M phases show high PLC-beta2 expressions that reach the greatest levels during the late mitotic stages. Phospholipase C-beta2 promotes mitosis and migration of human breast cancer-derived cells | Homo sapiens | - |
MDA-MB-231 cell | compared with the G0/G1 phases of the cell cycle, the cells in S/G2/M phases show high PLC-b2 expressions that reach the greatest levels during the late mitotic stages. Phospholipase C-beta2 promotes mitosis and migration of human breast cancer-derived cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PLC-beta2 may improve some malignant characteristics of tumor cells, like motility and invasion capability, but it fails to induce tumorigenesis in nontransformed breast-derived cells | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phospholipase C-beta 2 | - |
Homo sapiens |
PLC-beta2 | - |
Homo sapiens |