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Literature summary for 3.1.4.11 extracted from

  • Fukami, K.; Inanobe, S.; Kanemaru, K.; Nakamura, Y.
    Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance (2010), Prog. Lipid Res., 49, 429-437.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information generation of PLCbeta1, 2, 3, and 4 gene-deficient KO mice and analysis of the resulting phenotypes, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation Mus musculus 5829
-
cytosol PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation Homo sapiens 5829
-
cytosol PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation Rattus norvegicus 5829
-
plasma membrane PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation. Membrane association of PLCdelta1 is mediated by its PH domain Mus musculus 5886
-
plasma membrane PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation. Membrane association of PLCdelta1 is mediated by its PH domain Homo sapiens 5886
-
plasma membrane PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation. Membrane association of PLCdelta1 is mediated by its PH domain Rattus norvegicus 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ all PLC isozymes require calcium for their activity, the PLCdelta-type is one of the most sensitive to calcium, suggesting that the activity of the PLCdelta-type may be regulated by calcium. PLCzeta is extremely sensitive to the calcium concentration Mus musculus
Ca2+ all PLC isozymes require calcium for their activity, the PLCdelta-type is one of the most sensitive to calcium, suggesting that the activity of the PLCdelta-type may be regulated by calcium. PLCzeta is extremely sensitive to the calcium concentration Homo sapiens
Ca2+ all PLC isozymes require calcium for their activity, the PLCdelta-type is one of the most sensitive to calcium, suggesting that the activity of the PLCdelta-type may be regulated by calcium. PLCzeta is extremely sensitive to the calcium concentration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Mus musculus
-
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol products are two second messengers ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Homo sapiens
-
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol products are two second messengers ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Rattus norvegicus
-
1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol products are two second messengers ?
additional information Mus musculus PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho ?
-
?
additional information Homo sapiens PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho ?
-
?
additional information Rattus norvegicus PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiac myocyte
-
Mus musculus
-
cardiac myocyte
-
Homo sapiens
-
cardiac myocyte
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
Mus musculus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
Mus musculus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol products are two second messengers ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol products are two second messengers ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol products are two second messengers ?
additional information PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho Mus musculus ?
-
?
additional information PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho Homo sapiens ?
-
?
additional information PLCepsilon exhibits activity as RasGEF toward Rap1, but not to Ras, Rap2A or Rho Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
PLC
-
Mus musculus
PLC
-
Homo sapiens
PLC
-
Rattus norvegicus

General Information

General Information Comment Organism
malfunction PLC isozymes are involved in several diseases, detailed overview Mus musculus
malfunction PLC isozymes are involved in several diseases, detailed overview Homo sapiens
additional information co-expression of PLCeta2 and Gbetagamma protein results in higher PLC activity Mus musculus
additional information co-expression of PLCeta2 and Gbetagamma protein results in higher PLC activity Homo sapiens
additional information co-expression of PLCeta2 and Gbetagamma protein results in higher PLC activity Rattus norvegicus
physiological function PLC is involved in the regulation of proliferation, differentiation, and tumor formation, the switch between proliferation and differentiation is caused by PLCs. PLC regulates the spatio-temporal balance of phosphoinositides. Calcium mobilization is an essential cellular function of PLC. PLCzeta and PLCdelta4 are involved in the calcium increase in the first step of fertilization. PLCbeta- and PLCeta-type are involved in neuronal function. PLCdelta1 regulates skin homeostasis. The PLCepsilon is an effector of Ras protein, both upstream and downstream, and its activity is regulated by Ras in a GTP-dependent manner. PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation. Thus, targeting of PLC to the plasma membrane is a critical event for signal transduction. Association with heterotrimeric G-proteins of the Gq family induces the activity of beta-type PLCs. gamma-Type isozymes are regulated primarily by receptor and cytosolic tyrosine kinases, mechanisms, overview Mus musculus
physiological function PLC is involved in the regulation of proliferation, differentiation, and tumor formation, the switch between proliferation and differentiation is caused by PLCs. PLC regulates the spatio-temporal balance of phosphoinositides. Calcium mobilization is an essential cellular function of PLC. PLCzeta and PLCdelta4 are involved in the calcium increase in the first step of fertilization. PLCbeta- and PLCeta-type are involved in neuronal function. PLCdelta1 regulates skin homeostasis. The PLCepsilon is an effector of Ras protein, both upstream and downstream, and its activity is regulated by Ras in a GTP-dependent manner. PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation. Thus, targeting of PLC to the plasma membrane is a critical event for signal transduction. Association with heterotrimeric G-proteins of the Gq family induces the activity of beta-type PLCs. gamma-Type isozymes are regulated primarily by receptor and cytosolic tyrosine kinases, mechanisms, overview Homo sapiens
physiological function PLC is involved in the regulation of proliferation, differentiation, and tumor formation, the switch between proliferation and differentiation is caused by PLCs. PLC regulates the spatio-temporal balance of phosphoinositides. Calcium mobilization is an essential cellular function of PLC. PLCzeta and PLCdelta4 are involved in the calcium increase in the first step of fertilization. PLCbeta- and PLCeta-type are involved in neuronal function. PLCdelta1 regulates skin homeostasis. The PLCepsilon is an effector of Ras protein, both upstream and downstream, and its activity is regulated by Ras in a GTP-dependent manner. PLC is a soluble protein that is localized mainly in the cytosol and is translocated to the plasma membrane, where it hydrolyzes PI(4,5)P2 in response to cell activation. Thus, targeting of PLC to the plasma membrane is a critical event for signal transduction. Association with heterotrimeric G-proteins of the Gq family induces the activity of beta-type PLCs. gamma-Type isozymes are regulated primarily by receptor and cytosolic tyrosine kinases, mechanisms, overview Rattus norvegicus