Literature summary for 3.1.4.11 extracted from

Alvarez-Breckenridge, C.A.; Waite, K.A.; Eng, C.
PTEN regulates phospholipase D and phospholipase C (2007), Hum. Mol. Genet., 16, 1157-1163.

Search for more literature for 3.1.4.11

Activating Compound

Activating Compound	Comment	Organism	Structure
beta-estradiol	-	Homo sapiens
PTEN	ubiquitously expressed tumor suppressor. PTEN overexpression results in changes in cellular phospholipid levels. Increased PTEN expression in unstimulated MCF-7 breast cancer cells results in a 51% increase in phosphatidic acid, with a decrease in phosphatidylcholine, PTEN activates also phospholipase D (PLD). PTEN induces translocation of PLC-gamma from the cytosol to the membrane	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	PTEN induces translocation of PLC-gamma from the cytosol to the membrane	Homo sapiens	5829	-
membrane	PTEN induces translocation of PLC-gamma from the cytosol to the membrane	Homo sapiens	16020	-
additional information	PLC-gamma remains localized in the cytosolic compartment in the C124S-PTEN and G129E-PTEN cell lines where lipid-phosphatase-inactive PTEN is overexpressed	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	breast cancer cell line	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PLC-gamma	-	Homo sapiens

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Release 2023.1 (January 2023)