Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | requirement | Mus musculus | |
Ca2+ | requirement of all PLCs, the delta isoenzymes are most sensitive to Ca2+ | Homo sapiens | |
Ca2+ | requirement of all PLCs, the delta isoenzymes are most sensitive to Ca2+ | Rattus norvegicus | |
Ca2+ | requirement of all PLCs, the delta isoenzymes are most sensitive to Ca2+ | Bos taurus | |
additional information | regulation of the PLC delta isoenzymes | Homo sapiens | |
additional information | regulation of the PLC delta isoenzymes | Bos taurus | |
additional information | regulation of the PLC delta isoenzymes, acrylonitrile causes a significant increase in PLC delta1 level in the heart and cytosol of cerebral cortex | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | increased expression of R257H mutant PLC delta1 in patients with coronary spastic angina, enhanced PLC delta1 activity, but not beta or gamma, in patients suffering from essential hypertension, PLC delta2 plays a role in neoplastic evolution and could be a predictive marker of cancer transformation | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | PLC delta1-deficient mice, calcium and PKC activation are impaired in the keratinocytes and skin | Mus musculus |
R257H | increased expression of mutant PLC delta1 in patients with coronary spastic angina | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | regulation of the PLC delta isoenzymes | Bos taurus | |
additional information | regulation of the PLC delta isoenzymes | Homo sapiens | |
additional information | regulation of the PLC delta isoenzymes, under hyperoxia conditions acrylonitrile decreases PLC delta1 level, PLC delta4 gene is down-regulated after spinal cord injury | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Homo sapiens | PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | second messengers | ? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Rattus norvegicus | PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | second messengers | ? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Bos taurus | PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | second messengers | ? | |
additional information | Mus musculus | PLC delta1 is required for skin stem cell lineage commitment | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
four PLC delta isoenzymes: PLC delta1-4 | - |
Homo sapiens | - |
four PLC delta isoenzymes: PLC delta1-4 | - |
Mus musculus | - |
PLCdelta | - |
Rattus norvegicus | - |
four PLC delta isoenzymes: PLC delta1-4 | - |
Purification (Comment) | Organism |
---|---|
PLC delta2, from cerebral cortex | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adenocarcinoma cell | expression of PLC delta2 | Bos taurus | - |
aorta | PLC delta3 and delta4 | Rattus norvegicus | - |
brain | PLC delta1, delta3 and delta4 | Rattus norvegicus | - |
cardiac muscle | PLC delta3 and delta4 | Rattus norvegicus | - |
cerebral cortex | expression of PLC delta2 | Bos taurus | - |
fibroblast | W-138 fibroblasts, expression of PLC delta isoenzymes | Homo sapiens | - |
kidney | PLC delta3 and delta4 | Rattus norvegicus | - |
liver | PLC delta3 and delta4 | Rattus norvegicus | - |
lung | PLC delta1 | Rattus norvegicus | - |
additional information | PLC delta2 is not expressed in muscles and digestive organs, nor in hematopoietic cells and lymphoid tissues | Rattus norvegicus | - |
pheochromocytoma cell | expression of PLC delta | Rattus norvegicus | - |
skeletal muscle | PLC delta1 | Rattus norvegicus | - |
spleen | PLC delta1, delta3 and delta4 | Rattus norvegicus | - |
testis | PLC delta1, delta3 and delta4 | Rattus norvegicus | - |
type II intestinal metaplasia specific cell type | expression of PLC delta2 | Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | phosphoinositide-specific, PLC delta structure with EF-hand motif and PH domain | Homo sapiens | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | phosphoinositide-specific, PLC delta structure with EF-hand motif and PH domain | Rattus norvegicus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | phosphoinositide-specific, PLC delta structure with EF-hand motif and PH domain | Bos taurus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes | Homo sapiens | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | second messengers | ? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes | Rattus norvegicus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | second messengers | ? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes | Bos taurus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | second messengers | ? | |
additional information | PLC delta1 is required for skin stem cell lineage commitment | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
More | four major types of PLC: beta, gamma, delta and epsilon | Homo sapiens |
More | four major types of PLC: beta, gamma, delta and epsilon | Rattus norvegicus |
More | four major types of PLC: beta, gamma, delta and epsilon | Bos taurus |