Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.11 extracted from

  • Ochocka, A.M.; Pawelczyk, T.
    Isozymes delta of phosphoinositide-specific phospholipase C and their role in signal transduction in the cell (2003), Acta Biochim. Pol., 50, 1097-1110.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Ca2+ requirement Mus musculus
Ca2+ requirement of all PLCs, the delta isoenzymes are most sensitive to Ca2+ Homo sapiens
Ca2+ requirement of all PLCs, the delta isoenzymes are most sensitive to Ca2+ Rattus norvegicus
Ca2+ requirement of all PLCs, the delta isoenzymes are most sensitive to Ca2+ Bos taurus
additional information regulation of the PLC delta isoenzymes Homo sapiens
additional information regulation of the PLC delta isoenzymes Bos taurus
additional information regulation of the PLC delta isoenzymes, acrylonitrile causes a significant increase in PLC delta1 level in the heart and cytosol of cerebral cortex Rattus norvegicus

Application

Application Comment Organism
medicine increased expression of R257H mutant PLC delta1 in patients with coronary spastic angina, enhanced PLC delta1 activity, but not beta or gamma, in patients suffering from essential hypertension, PLC delta2 plays a role in neoplastic evolution and could be a predictive marker of cancer transformation Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information PLC delta1-deficient mice, calcium and PKC activation are impaired in the keratinocytes and skin Mus musculus
R257H increased expression of mutant PLC delta1 in patients with coronary spastic angina Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information regulation of the PLC delta isoenzymes Bos taurus
additional information regulation of the PLC delta isoenzymes Homo sapiens
additional information regulation of the PLC delta isoenzymes, under hyperoxia conditions acrylonitrile decreases PLC delta1 level, PLC delta4 gene is down-regulated after spinal cord injury Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Homo sapiens PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol second messengers ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Rattus norvegicus PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol second messengers ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O Bos taurus PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol second messengers ?
additional information Mus musculus PLC delta1 is required for skin stem cell lineage commitment ?
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
four PLC delta isoenzymes: PLC delta1-4
-
Homo sapiens
-
four PLC delta isoenzymes: PLC delta1-4
-
Mus musculus
-
PLCdelta
-
Rattus norvegicus
-
four PLC delta isoenzymes: PLC delta1-4
-

Purification (Commentary)

Purification (Comment) Organism
PLC delta2, from cerebral cortex Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adenocarcinoma cell expression of PLC delta2 Bos taurus
-
aorta PLC delta3 and delta4 Rattus norvegicus
-
brain PLC delta1, delta3 and delta4 Rattus norvegicus
-
cardiac muscle PLC delta3 and delta4 Rattus norvegicus
-
cerebral cortex expression of PLC delta2 Bos taurus
-
fibroblast W-138 fibroblasts, expression of PLC delta isoenzymes Homo sapiens
-
kidney PLC delta3 and delta4 Rattus norvegicus
-
liver PLC delta3 and delta4 Rattus norvegicus
-
lung PLC delta1 Rattus norvegicus
-
additional information PLC delta2 is not expressed in muscles and digestive organs, nor in hematopoietic cells and lymphoid tissues Rattus norvegicus
-
pheochromocytoma cell expression of PLC delta Rattus norvegicus
-
skeletal muscle PLC delta1 Rattus norvegicus
-
spleen PLC delta1, delta3 and delta4 Rattus norvegicus
-
testis PLC delta1, delta3 and delta4 Rattus norvegicus
-
type II intestinal metaplasia specific cell type expression of PLC delta2 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O phosphoinositide-specific, PLC delta structure with EF-hand motif and PH domain Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O phosphoinositide-specific, PLC delta structure with EF-hand motif and PH domain Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O phosphoinositide-specific, PLC delta structure with EF-hand motif and PH domain Bos taurus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes Homo sapiens 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol second messengers ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol second messengers ?
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O PLC is crucial for the phosphoinositol pathways and involved in eukaryotic signal transduction as it generates two second messengers, regulation of the PLC delta isoenzymes Bos taurus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol second messengers ?
additional information PLC delta1 is required for skin stem cell lineage commitment Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
More four major types of PLC: beta, gamma, delta and epsilon Homo sapiens
More four major types of PLC: beta, gamma, delta and epsilon Rattus norvegicus
More four major types of PLC: beta, gamma, delta and epsilon Bos taurus