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Literature summary for 3.1.4.11 extracted from
- Structure-activity relationship of pentacylic triterpene esters from Uncaria rhynchophylla as inhibitors of phospholipase Cgamma1 (2008), Planta Med., 74, 1481-1487.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3beta,27-dihydroxyurs-12-en-28-oic acid | - |
Homo sapiens |  |
| 3beta,27-dihydroxyurs-12-en-28-oic acid | - |
Mus musculus | |
| 3beta,7'-diacetoxy-27- 4-(E)-coumaroyloxyurs-12-en-28-oic acid | - |
Homo sapiens | |
| 3beta,7'-diacetoxy-27- 4-(E)-coumaroyloxyurs-12-en-28-oic acid | - |
Mus musculus | |
| 3beta-4-(E)-coumaroyloxyurs-12-en-28-oic acid | - |
Homo sapiens | |
| 3beta-4-(E)-coumaroyloxyurs-12-en-28-oic acid | - |
Mus musculus | |
| 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | - |
Homo sapiens | |
| 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | - |
Mus musculus | |
| 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | - |
Homo sapiens | |
| 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | - |
Mus musculus | |
| 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | - |
Homo sapiens | |
| 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | - |
Mus musculus | |
| 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | - |
Homo sapiens | |
| 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | - |
Mus musculus | |
| 3beta-hydroxy-27-4-(E)-2'-dihydrocoumaroyloxyurs-12-en-28-oic acid | - |
Homo sapiens | |
| 3beta-hydroxy-27-4-(E)-2'-dihydrocoumaroyloxyurs-12-en-28-oic acid | - |
Mus musculus | |
| 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | - |
Homo sapiens | |
| 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | - |
Mus musculus | |
| 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | - |
Homo sapiens | |
| 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | - |
Mus musculus | |
| 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic methyl ester | - |
Homo sapiens | |
| 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic methyl ester | - |
Mus musculus | |
| 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | - |
Homo sapiens | |
| 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | - |
Mus musculus | |
| 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | - |
Homo sapiens | |
| 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | - |
Mus musculus | |
| 3beta-hydroxyurs-12-en-28-oic 4-(E)-coumaroyl ester | - |
Homo sapiens | |
| 3beta-hydroxyurs-12-en-28-oic 4-(E)-coumaroyl ester | - |
Mus musculus | |
| 4-(E)-coumaric acid | - |
Homo sapiens | |
| 4-(E)-coumaric acid | - |
Mus musculus | |
| adriamycin | - |
Homo sapiens | |
| adriamycin | - |
Mus musculus | |
| amentoflavone | - |
Homo sapiens | |
| amentoflavone | - |
Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-549 cell | - |
Homo sapiens | - |
| CCD-18Co cell | - |
Homo sapiens | - |
| HT-1197 cell | - |
Homo sapiens | - |
| MCF-7 cell | - |
Homo sapiens | - |
| P-388 cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Mus musculus | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
| 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Homo sapiens | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phosphatidylinositol specific phospholipase C | - |
Mus musculus |
| phosphatidylinositol specific phospholipase C | - |
Homo sapiens |
| phospholipase Cgamma1 | - |
Mus musculus |
| phospholipase Cgamma1 | - |
Homo sapiens |
| PI-PLC | - |
Mus musculus |
| PI-PLC | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| additional information | - |
IC50 value is less than 0.1 microM for adriamycin in in P388 cells, pH 7.0, 37°C | Mus musculus | additional information | |
| additional information | - |
IC50 value is less than 0.1 microM for adriamycin in MCF7 cells, pH 7.0, 37°C | Homo sapiens | additional information | |
| additional information | - |
the IC50 values for 3beta,7'-diacetoxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid, 3beta-hydroxyurs-12-en-28-oic 4-(E)-coumaroyl ester, 3beta,27-dihydroxyurs-12-en-28-oic acid, 3beta-4-(E)-coumaroyloxyurs-12-en-28-oic acid, and 4-(E)-coumaric acidare above 0.250 mM, pH 7.0, 37°C | Homo sapiens | additional information | |
| 0.0001 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | adriamycin | |
| 0.0004 | - |
colony-forming, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the HCT-15 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C | Homo sapiens | adriamycin | |
| 0.0007 | - |
colony-forming, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the A549 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C | Homo sapiens | adriamycin | |
| 0.0008 | - |
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.0008 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.0009 | - |
in MCF7 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0009 | - |
in MCF7 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
| 0.001 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0013 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | adriamycin | |
| 0.0013 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | adriamycin | |
| 0.0014 | - |
in MCF7 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0017 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.0018 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0019 | - |
in MCF7 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.002 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.0021 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.0021 | - |
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0021 | - |
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0021 | - |
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.0021 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0021 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0021 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.0021 | - |
in MCF7 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.0024 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0027 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0028 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
| 0.0029 | - |
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
| 0.0029 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
| 0.003 | - |
in MCF7 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0032 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.0035 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0037 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.0038 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0038 | - |
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
| 0.0038 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
| 0.004 | - |
in MCF7 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0041 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
| 0.0043 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
| 0.0043 | - |
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0043 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0045 | - |
in HCT-15 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0045 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0047 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0051 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0054 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0065 | - |
in A549 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0066 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.0067 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
| 0.0072 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0076 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0091 | - |
in HT-1 197 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
| 0.0091 | - |
in MCF7 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
| 0.0095 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.01 | - |
in A549 cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
| 0.0101 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | adriamycin | |
| 0.0143 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
| 0.0174 | - |
in P388 cells, pH 7.0, 37°C | Mus musculus | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.0175 | - |
in P388 cells, pH 7.0, 37°C | Mus musculus | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0182 | - |
in P388 cells, pH 7.0, 37°C | Mus musculus | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0186 | - |
in P388 cells, pH 7.0, 37°C | Mus musculus | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.022 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.0226 | - |
in P388 cells, pH 7.0, 37°C | Mus musculus | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0229 | - |
in P388 cells, pH 7.0, 37°C | Mus musculus | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
| 0.0229 | - |
in P388 cells, pH 7.0, 37°C | Mus musculus | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
| 0.0245 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0245 | - |
in P388 cells, pH 7.0, 37°C | Mus musculus | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0246 | - |
in HCT-15 cells, pH 7.0, 37°C | Homo sapiens | adriamycin | |
| 0.0246 | - |
in HT-1 197 cells, cytotoxic effects in log phase S, pH 7.0, 37°C | Homo sapiens | adriamycin | |
| 0.0246 | - |
sulforhodamine B, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the HCT-15 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C | Homo sapiens | adriamycin | |
| 0.0277 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.029 | - |
pH 7.0, 37°C | Homo sapiens | amentoflavone | |
| 0.0355 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyurs-12-en-28-oic acid | |
| 0.0357 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0438 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
| 0.0441 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyurs-12-en-28-oic acid | |
| 0.0446 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0503 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(Z)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0524 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.059 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyolea-12-en-28-oic acid | |
| 0.0614 | - |
sulforhodamine B, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the HCT-15 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.065 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0666 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-(E)-feruloyloxyolea-12-en-28-oic acid | |
| 0.0733 | - |
in CCD-18Co cells, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(Z)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0737 | - |
colony-forming, cytotoxic effects of 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid on the HCT-15 cell line by the sulforhodamine B (SRB) and colony forming assays, pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic acid | |
| 0.0836 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-2'-dihydrocoumaroyloxyurs-12-en-28-oic acid | |
| 0.1213 | - |
pH 7.0, 37°C | Homo sapiens | 3beta-hydroxy-27-4-(E)-coumaroyloxyurs-12-en-28-oic methyl ester | |
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