Cloned (Comment) | Organism |
---|---|
two distinct PLCbeta1 cDNAs, PLCbeta1a and b, generated through alternative splicing at their 3 end, sequencing, overexpression in CHO and PC12 cells, gene structure, located on chromosome 20 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell membrane | inner side, PLCbeta1 | Homo sapiens | - |
- |
cytoplasm | PLCbeta1 | Homo sapiens | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Homo sapiens | key step in the intracellular transduction of a large number of extracellular signals, including neurotransmitters and hormones modulating diverse developmental and functional aspects of the central nervous system | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | second messengers | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NQ66 | PLCbeta1a; two isoforms of PLCbeta1, a and b | - |
Homo sapiens | Q9NQ66 | PLCbeta1b; two isoforms of PLCbeta1, a and b | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amygdala | highest expression level of PLCbeta1 in brain, especially in the amygdala, caudate nucleus and hippocampus | Homo sapiens | - |
brain | adult, highest expression level of PLCbeta1 in brain, especially in the amygdala, caudate nucleus and hippocampus | Homo sapiens | - |
caudate nucleus | highest expression level of PLCbeta1 in brain, especially in the amygdala, caudate nucleus and hippocampus | Homo sapiens | - |
hippocampus | highest expression level of PLCbeta1 in brain, especially in the amygdala, caudate nucleus and hippocampus | Homo sapiens | - |
additional information | expression patterns of the two PLCbeta1 isoforms in a comprehensive panel of tissues | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | phosphoinositide-specific | Homo sapiens | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | - |
? | |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | key step in the intracellular transduction of a large number of extracellular signals, including neurotransmitters and hormones modulating diverse developmental and functional aspects of the central nervous system | Homo sapiens | 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | second messengers | ? |