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Information on EC 2.8.4.1 - coenzyme-B sulfoethylthiotransferase

for references in articles please use BRENDA:EC2.8.4.1
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IUBMB Comments
This enzyme catalyses the final step in methanogenesis, the biological production of methane. This important anaerobic process is carried out only by methanogenic archaea. The enzyme can also function in reverse, for anaerobic oxidation of methane.The enzyme requires the hydroporphinoid nickel complex coenzyme F430. Highly specific for coenzyme B with a heptanoyl chain; ethyl CoM and difluoromethyl CoM are poor substrates. The sulfide sulfur can be replaced by selenium but not by oxygen.
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Word Map
The expected taxonomic range for this enzyme is: Archaea, Bacteria
Synonyms
2-(methylthio)ethanesulfonic acid reductase, Coenzyme-B sulfoethylthiotransferase alpha, Coenzyme-B sulfoethylthiotransferase beta, Coenzyme-B sulfoethylthiotransferase gamma, MCR, MCR I, MCR I alpha, MCR I beta, MCR I gamma, MCR II, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
methyl-CoM + CoB = CoM-S-S-CoB + methane
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