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Literature summary for 2.8.4.1 extracted from

  • McKay, L.J.; Hatzenpichler, R.; Inskeep, W.P.; Fields, M.W.
    Occurrence and expression of novel methyl-coenzyme M reductase gene (mcrA) variants in hot spring sediments (2017), Sci. Rep., 7, 7252 .
    View publication on PubMedView publication on EuropePMC

Metals/Ions

Metals/Ions Comment Organism Structure
Ni2+ contained in the coenzyme F430 Euryarchaeota
Ni2+ contained in the coenzyme F430 Candidatus Bathyarchaeota
Ni2+ contained in the coenzyme F430 Candidatus Verstraetearchaeota

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
methyl-CoM + CoB Euryarchaeota
-
CoM-S-S-CoB + methane
-
?
methyl-CoM + CoB Candidatus Bathyarchaeota
-
CoM-S-S-CoB + methane
-
?
methyl-CoM + CoB Candidatus Verstraetearchaeota
-
CoM-S-S-CoB + methane
-
?

Organism

Organism UniProt Comment Textmining
Candidatus Bathyarchaeota
-
isolated in Yellowstone National Park (YNP, Wyoming, USA) from Washburn Hot Springs (WS) and Heart Lake Geyser Basin (HL)
-
Candidatus Verstraetearchaeota
-
isolated in Yellowstone National Park (YNP, Wyoming, USA) from Washburn Hot Springs (WS) and Heart Lake Geyser Basin (HL)
-
Euryarchaeota
-
isolated in Yellowstone National Park (YNP, Wyoming, USA) from Washburn Hot Springs (WS) and Heart Lake Geyser Basin (HL)
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methyl-CoM + CoB
-
Euryarchaeota CoM-S-S-CoB + methane
-
?
methyl-CoM + CoB
-
Candidatus Bathyarchaeota CoM-S-S-CoB + methane
-
?
methyl-CoM + CoB
-
Candidatus Verstraetearchaeota CoM-S-S-CoB + methane
-
?

Synonyms

Synonyms Comment Organism
mcrA gene name, encoding subunit A Euryarchaeota
mcrA gene name, encoding subunit A Candidatus Bathyarchaeota
mcrA gene name, encoding subunit A Candidatus Verstraetearchaeota
methyl-coenzyme M reductase
-
Euryarchaeota
methyl-coenzyme M reductase
-
Candidatus Bathyarchaeota
methyl-coenzyme M reductase
-
Candidatus Verstraetearchaeota

Cofactor

Cofactor Comment Organism Structure
F-430 coenzyme F430, rapid kinetic studies rule out methyl-Ni(III) and trap the MCRox1-silent intermediate. Identification of an MCRox1-like state, specifically a F430-Ni(III)-SCoM/CoBS- intermediate, from direct DFT calculations Euryarchaeota
F-430 coenzyme F430, rapid kinetic studies rule out methyl-Ni(III) and trap the MCRox1-silent intermediate. Identification of an MCRox1-like state, specifically a F430-Ni(III)-SCoM/CoBS- intermediate, from direct DFT calculations Candidatus Bathyarchaeota
F-430 coenzyme F430, rapid kinetic studies rule out methyl-Ni(III) and trap the MCRox1-silent intermediate. Identification of an MCRox1-like state, specifically a F430-Ni(III)-SCoM/CoBS- intermediate, from direct DFT calculations Candidatus Verstraetearchaeota

General Information

General Information Comment Organism
evolution the marker gene for anaerobic methane cycling (mcrA) is more widespread in the Archaea than previously thought. Small-subunit (SSU) rRNA gene analyses indicate that Bathyarchaeota are predominant in seven of ten sediment layers, while the Verstraetearchaeota and Euryarchaeota occur in lower relative abundance. Targeted amplification of mcrA genes suggests that diverse taxa contribute to alkane cycling in geothermal environments. Two deeply-branching mcrA clades related to Bathyarchaeota are identified, while highly abundant verstraetearchaeotal mcrA sequences are also recovered. SSU rRNA gene survey of Archaea and phylogenetic analysis and distribution, overview Euryarchaeota
evolution the marker gene for anaerobic methane cycling (mcrA) is more widespread in the Archaea than previously thought. Small-subunit (SSU) rRNA gene analyses indicate that Bathyarchaeota are predominant in seven of ten sediment layers, while the Verstraetearchaeota and Euryarchaeota occur in lower relative abundance. Targeted amplification of mcrA genes suggests that diverse taxa contribute to alkane cycling in geothermal environments. Two deeply-branching mcrA clades related to Bathyarchaeota are identified, while highly abundant verstraetearchaeotal mcrA sequences are also recovered. SSU rRNA gene survey of Archaea and phylogenetic analysis and distribution, overview Candidatus Bathyarchaeota
evolution the marker gene for anaerobic methane cycling (mcrA) is more widespread in the Archaea than previously thought. Small-subunit (SSU) rRNA gene analyses indicate that Bathyarchaeota are predominant in seven of ten sediment layers, while the Verstraetearchaeota and Euryarchaeota occur in lower relative abundance. Targeted amplification of mcrA genes suggests that diverse taxa contribute to alkane cycling in geothermal environments. Two deeply-branching mcrA clades related to Bathyarchaeota are identified, while highly abundant verstraetearchaeotal mcrA sequences are also recovered. SSU rRNA gene survey of Archaea and phylogenetic analysis and distribution, overview Candidatus Verstraetearchaeota
physiological function the enzyme is involved in anaerobic alkane cycling Euryarchaeota
physiological function the enzyme is involved in anaerobic alkane cycling Candidatus Bathyarchaeota
physiological function the enzyme is involved in anaerobic alkane cycling Candidatus Verstraetearchaeota