Reference on EC 2.7.4.21 - inositol-hexakisphosphate 5-kinase and Organism(s) Homo sapiens and UniProt Accession O43314
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Saiardi, A.; Erdjument-Bromage, H.; Snowman, A.M.; Tempst, P.; Snyder, S.H.
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases
Curr. Biol.
9
1323-1326
1999
Homo sapiens (Q9UHH9), Mus musculus (Q6PD10)
Albert, C.; Safrany, S.T.; Bembenek, M.E.; Reddy, K.M.; Reddy, K.K.; Falck, J.R.; Brcker, M.; Shears, S.B.; Mayr, G.W.
Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells
Biochem. J.
327
553-560
1997
Cricetulus griseus, Homo sapiens, Mus musculus
-
Morrison, B.H.; Bauer, J.A.; Kalvakolanu, D.V.; Lindner, D.J.
Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells
J. Biol. Chem.
276
24965-24970
2001
Homo sapiens (Q9UHH9), Homo sapiens
Saiardi, A.; Nagata, E.; Luo, H.R.; Snowman, A.M.; Snyder, S.H.
Identification and characterization of a novel inositol hexakisphosphate kinase
J. Biol. Chem.
276
39179-39185
2001
Mus musculus, Homo sapiens (Q96PC2)
Morrison, B.H.; Tang, Z.; Jacobs, B.S.; Bauer, J.A.; Lindner, D.J.
Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-beta-induced apoptosis in ovarian carcinoma
Biochem. J.
385
595-603
2005
Homo sapiens
Nagata, E.; Luo, H.R.; Saiardi, A.; Bae, B.I.; Suzuki, N.; Snyder, S.H.
Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death
J. Biol. Chem.
280
1634-1640
2005
Homo sapiens
Morrison, B.H.; Bauer, J.A.; Hu, J.; Grane, R.W.; Ozdemir, A.M.; Chawla-Sarkar, M.; Gong, B.; Almasan, A.; Kalvakolanu, D.V.; Lindner, D.J.
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics
Oncogene
21
1882-1889
2002
Homo sapiens
Morrison, B.H.; Bauer, J.A.; Lupica, J.A.; Tang, Z.; Schmidt, H.; DiDonato, J.A.; Lindner, D.J.
Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation
J. Biol. Chem.
282
15349-15356
2007
Homo sapiens, Mus musculus
Weaver, J.D.; Wang, H.; Shears, S.B.
The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment
Biosci. Rep.
33
e00022
2013
Homo sapiens (O43314), Homo sapiens
Nagata, E.; Saiardi, A.; Tsukamoto, H.; Okada, Y.; Itoh, Y.; Satoh, T.; Itoh, J.; Margolis, R.L.; Takizawa, S.; Sawa, A.; Takagi, S.
Inositol hexakisphosphate kinases induce cell death in Huntington disease
J. Biol. Chem.
286
26680-26686
2011
Homo sapiens
Prasad, A.; Jia, Y.; Chakraborty, A.; Li, Y.; Jain, S.K.; Zhong, J.; Roy, S.G.; Loison, F.; Mondal, S.; Sakai, J.; Blanchard, C.; Snyder, S.H.; Luo, H.R.
Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling
Nat. Immunol.
12
752-760
2011
Homo sapiens, Mus musculus
Koldobskiy, M.A.; Chakraborty, A.; Werner, J.K.; Snowman, A.M.; Juluri, K.R.; Vandiver, M.S.; Kim, S.; Heletz, S.; Snyder, S.H.
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2
Proc. Natl. Acad. Sci. USA
107
20947-20951
2010
Homo sapiens
Wundenberg, T.; Grabinski, N.; Lin, H.; Mayr, G.W.
Discovery of InsP6-kinases as InsP6-dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio
Biochem. J.
462
173-184
2014
Homo sapiens, Rattus norvegicus
Chanduri, M.; Rai, A.; Malla, A.B.; Wu, M.; Fiedler, D.; Mallik, R.; Bhandari, R.
Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport
Biochem. J.
473
3031-3047
2016
Dictyostelium discoideum, Homo sapiens (Q92551), Mus musculus (Q6PD10), Mus musculus C57BL/6 (Q6PD10)
Wang, H.; Godage, H.Y.; Riley, A.M.; Weaver, J.D.; Shears, S.B.; Potter, B.V.
Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery
Chem. Biol.
21
689-699
2014
Homo sapiens (O43314)
Nagata, E.; Nonaka, T.; Moriya, Y.; Fujii, N.; Okada, Y.; Tsukamoto, H.; Itoh, J.; Okada, C.; Satoh, T.; Arai, T.; Hasegawa, M.; Takizawa, S.
Inositol hexakisphosphate kinase 2 promotes cell death in cells with cytoplasmic TDP-43 aggregation
Mol. Neurobiol.
53
5377-5383
2016
Homo sapiens (Q9UHH9), Homo sapiens
Nair, V.; Gu, C.; Janoshazi, A.; Jessen, H.; Wang, H.; Shears, S.
Inositol pyrophosphate synthesis by diphosphoinositol pentakisphosphate kinase-1 is regulated by phosphatidylinositol(4,5)bisphosphate
Biosci. Rep.
38
BSR20171549
2018
Homo sapiens (Q6PFW1)
Rajasekaran, S.S.; Kim, J.; Gaboardi, G.C.; Gromada, J.; Shears, S.B.; Dos Santos, K.T.; Nolasco, E.L.; Ferreira, S.S.; Illies, C.; Koehler, M.; Gu, C.; Ryu, S.H.; Martins, J.O.; Dare, E.; Barker, C.J.; Berggren, P.O.
Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic beta-cells
Cell. Signal.
46
120-128
2018
Mus musculus (Q6PD10), Homo sapiens (Q92551)
Gu, C.; Nguyen, H.N.; Hofer, A.; Jessen, H.J.; Dai, X.; Wang, H.; Shears, S.B.
The significance of the bifunctional kinase/phosphatase activities of diphosphoinositol pentakisphosphate kinases (PPIP5Ks) for coupling inositol pyrophosphate cell signaling to cellular phosphate homeostasis
J. Biol. Chem.
292
4544-4555
2017
Homo sapiens (O43314), Homo sapiens (Q6PFW1)
Wilson, M.S.; Jessen, H.J.; Saiardi, A.
The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export
J. Biol. Chem.
294
11597-11608
2019
Homo sapiens (Q92551), Homo sapiens (Q9UHH9), Homo sapiens
Nagata, E.; Fujii, N.; Kohara, S.; Okada, C.; Satoh, T.; Takekoshi, S.; Takao, M.; Mihara, B.; Takizawa, S.
Inositol hexakisphosphate kinase 2 promotes cell death of anterior horn cells in the spinal cord of patients with myotrophic lateral sclerosis
Mol. Biol. Rep.
47
6479-6485
2020
Homo sapiens (Q9UHH9), Homo sapiens
Yousaf, R.; Gu, C.; Ahmed, Z.M.; Khan, S.N.; Friedman, T.B.; Riazuddin, S.; Shears, S.B.; Riazuddin, S.
Mutations in diphosphoinositol-pentakisphosphate kinase PPIP5K2 are associated with hearing loss in human and mouse
PLoS Genet.
14
e1007297
2018
Homo sapiens (O43314), Homo sapiens
Wormald, M.; Liao, G.; Kimos, M.; Barrow, J.; Wei, H.
Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity
PLoS ONE
12
e0188852
2017
Homo sapiens (Q92551), Homo sapiens
Rojas, T.; Cheng, W.; Gao, Z.; Liu, X.; Wang, Y.; Malla, A.P.; Chin, A.C.; Romer, L.H.; Snyder, S.H.; Fu, C.
Inositol hexakisphosphate kinase 3 promotes focal adhesion turnover via interactions with dynein intermediate chain 2
Proc. Natl. Acad. Sci. USA
116
3278-3287
2019
Mus musculus (Q8BWD2), Homo sapiens (Q96PC2)
