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Literature summary for 2.7.4.21 extracted from

  • Wormald, M.; Liao, G.; Kimos, M.; Barrow, J.; Wei, H.
    Development of a homogenous high-throughput assay for inositol hexakisphosphate kinase 1 activity (2017), PLoS ONE, 12, e0188852 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.21

Inhibitors

Inhibitors Comment Organism Structure
6-hydroxy-DL-DOPA
-
 Homo sapiens
myricetin
-
 Homo sapiens
N2-(m-trifluorobenzyl),N6-(p-nitrobenzyl)purine ATP competitive inhibitor Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.382
-
 ATP pH 6.95, 37°C Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol hexakisphosphate Homo sapiens
-
 ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92551
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
 ?
ATP + 1D-myo-inositol hexakisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
inositol hexakisphosphate kinase 1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00184
-
 pH 6.95, 37°C Homo sapiens 6-hydroxy-DL-DOPA
0.00496
-
 pH 6.95, 37°C Homo sapiens myricetin
0.0095
-
 pH 6.95, 37°C, in presence of 0.4 mM 1D-myo-inositol hexakisphosphate Homo sapiens N2-(m-trifluorobenzyl),N6-(p-nitrobenzyl)purine
0.012
-
 pH 6.95, 37°C Homo sapiens N2-(m-trifluorobenzyl),N6-(p-nitrobenzyl)purine
0.016
-
 pH 6.95, 37°C, in presence of 0.25 mM ATP Homo sapiens N2-(m-trifluorobenzyl),N6-(p-nitrobenzyl)purine
0.02
-
 pH 6.95, 37°C, in presence of 0.1 mM 1D-myo-inositol hexakisphosphate Homo sapiens N2-(m-trifluorobenzyl),N6-(p-nitrobenzyl)purine
0.021
-
 pH 6.95, 37°C, in presence of 0.2 mM 1D-myo-inositol hexakisphosphate Homo sapiens N2-(m-trifluorobenzyl),N6-(p-nitrobenzyl)purine
0.024
-
 pH 6.95, 37°C, in presence of 0.05 mM 1D-myo-inositol hexakisphosphate Homo sapiens N2-(m-trifluorobenzyl),N6-(p-nitrobenzyl)purine
0.039
-
 pH 6.95, 37°C, in presence of 2.0 mM ATP Homo sapiens N2-(m-trifluorobenzyl),N6-(p-nitrobenzyl)purine

General Information

General Information Comment Organism
additional information a homogenous coupled bioluminescence assay is developed for measuring inositol hexakisphosphate kinase 1 activity in a 384-well format Homo sapiens
physiological function the enzyme is important in numerous areas of cell physiology such as DNA repair and glucose homeostasis. It is implicated in the pathology of diabetes and other human diseases Homo sapiens