Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q92551 | - |
- |
Homo sapiens | Q9UHH9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HCT-116 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
IP6K1 | - |
Homo sapiens |
IP6K2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | IP6K1/2-knockout cells have nondetectable levels of the IP6-derived 5-diphosphoinositol pentakisphosphate and bisdiphosphoinositol tetrakisphosphate and also exhibit reduced synthesis of the 5-diphosphoinositol pentakisphosphate-derived diphosphoinositol tetrakisphosphate. Knockout cells contain increased amounts of ATP, and elevated levels of free intracellular phosphate. Phosphate import and export of phosphate are decreased in the knockout cells | Homo sapiens |
physiological function | inositol hexakisphosphate kinase (IP6K1) and IP6K2 together control inositol pyrophosphate metabolism and thereby physiologically regulate phosphate export and other aspects of mammalian cellular phosphate homeostasis | Homo sapiens |