Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | isoform InsP6K2 is localized mainly in the cytoplasm of lymphoblast cells from patients with Huntington disease | Homo sapiens | 5737 | - |
nucleus | isoform InsP6K2 is localized mainly in the nucleus of normal lymphoblast cells | Homo sapiens | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
x * 50000, isoform InsP6K2, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
lymphoblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol hexakisphosphate | - |
Homo sapiens | ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000, isoform InsP6K2, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
inositol hexakisphosphate kinase type 2 | - |
Homo sapiens |
InsP6K2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | inositol hexakisphosphate kinase induces cell death in Huntington disease. The enzyme mediates apoptotic cell death via its translocation from the nucleus to the cytoplasm. Overexpression of the enzyme leads to the depletion of Akt phosphorylation and the induction of cell death | Homo sapiens |