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Literature summary for 2.7.4.21 extracted from

  • Nagata, E.; Saiardi, A.; Tsukamoto, H.; Okada, Y.; Itoh, Y.; Satoh, T.; Itoh, J.; Margolis, R.L.; Takizawa, S.; Sawa, A.; Takagi, S.
    Inositol hexakisphosphate kinases induce cell death in Huntington disease (2011), J. Biol. Chem., 286, 26680-26686.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm isoform InsP6K2 is localized mainly in the cytoplasm of lymphoblast cells from patients with Huntington disease Homo sapiens 5737
-
nucleus isoform InsP6K2 is localized mainly in the nucleus of normal lymphoblast cells Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
x * 50000, isoform InsP6K2, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-
lymphoblast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol hexakisphosphate
-
Homo sapiens ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate
-
?

Subunits

Subunits Comment Organism
? x * 50000, isoform InsP6K2, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
inositol hexakisphosphate kinase type 2
-
Homo sapiens
InsP6K2
-
Homo sapiens

General Information

General Information Comment Organism
physiological function inositol hexakisphosphate kinase induces cell death in Huntington disease. The enzyme mediates apoptotic cell death via its translocation from the nucleus to the cytoplasm. Overexpression of the enzyme leads to the depletion of Akt phosphorylation and the induction of cell death Homo sapiens