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Literature summary for 2.7.4.21 extracted from

  • Saiardi, A.; Nagata, E.; Luo, H.R.; Snowman, A.M.; Snyder, S.H.
    Identification and characterization of a novel inositol hexakisphosphate kinase (2001), J. Biol. Chem., 276, 39179-39185.
    View publication on PubMed
Search for more literature for 2.7.4.21

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0009
-
 Inositol hexakisphosphate pH 7.0, 37°C Homo sapiens
0.0055
-
 D-myo-inositol-1,3,4,5,6-pentakisphosphate pH 7.0, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm predominate in cytoplasm with only modest nuclear levels Homo sapiens 5737
-
cytoplasm comparable amounts of activity in the nucleus and cytoplasm Mus musculus 5737
-
cytoplasmic vesicle low level of activity Homo sapiens 31410
-
nucleus predominate in cytoplasm with only modest nuclear levels Homo sapiens 5634
-
nucleus comparable amounts of activity in the nucleus and cytoplasm Mus musculus 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96PC2
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
cerebellum
-
 Mus musculus
-
cerebellum highest activity occurs in Purkinje cells with somewhat lower levels in granule cells. In hippocampus substantial densities occur in CA1-CA4 layers of the hippocampus as well as the dentate gyrus Homo sapiens
-
hippocampus
-
 Homo sapiens
-
kidney moderate activity Homo sapiens
-
neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol hexakisphosphate
-
 Mus musculus ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol hexakisphosphate
-
 Homo sapiens ADP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol-1,3,4,5,6-pentakisphosphate
-
 Homo sapiens ADP + diphospho-1D-myo-inositol tetrakisphosphate
-
 ?