Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N2-(3-trifluorobenzyl)-N6-(4-nitrobenzyl)purine | TNP, a selective IP6K inhibitor, abolishes the production of enantiomer Ins(2,3,4,5,6)P5 in different types of cells | Homo sapiens | |
N2-(3-trifluorobenzyl)-N6-(4-nitrobenzyl)purine | TNP, a selective IP6K inhibitor, abolishes the production of enantiomer Ins(2,3,4,5,6)P5 in different types of cells | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Rattus norvegicus | 5829 | - |
nucleus | - |
Homo sapiens | 5634 | - |
nucleus | - |
Rattus norvegicus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1D-myo-inositol hexakisphosphate | - |
Homo sapiens | ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate | - |
? | |
ATP + 1D-myo-inositol hexakisphosphate | - |
Rattus norvegicus | ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate | - |
? | |
additional information | IP6Ks change their kinase activity towards InsP6 at a decreasing ATP/ADP ratio to an ADP phosphotransferase activity and dephosphorylate InsP6. Enantioselective analysis reveals that Ins(2,3,4,5,6)P5 is the main InsP5 product of the IP6K reaction | Homo sapiens | ? | - |
? | |
additional information | IP6Ks change their kinase activity towards InsP6 at a decreasing ATP/ADP ratio to an ADP phosphotransferase activity and dephosphorylate InsP6. Enantioselective analysis reveals that Ins(2,3,4,5,6)P5 is the main InsP5 product of the IP6K reaction | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
InsP6-kinase | - |
Homo sapiens |
InsP6-kinase | - |
Rattus norvegicus |
IP6K | - |
Homo sapiens |
IP6K | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
additional information | lentiviral RNAi-based depletion of MINPP1 at falling cellular ATP/ADP ratios has no significant impact on Ins(2,3,4,5,6)P5 production | Homo sapiens |
additional information | lentiviral RNAi-based depletion of MINPP1 at falling cellular ATP/ADP ratios has no significant impact on Ins(2,3,4,5,6)P5 production | Rattus norvegicus |
physiological function | InsP6 (inositol hexakisphosphate), the most abundant inositol phosphate in metazoa, is pyrophosphorylated to InsP7 [5PP-InsP5 (diphosphoinositol pentakisphosphate)] by cytosolic and nuclear IP6Ks (InsP6 kinases) and to 1PP-InsP5 by another InsP6/InsP7 kinase family. IP6Ks are also nuclear and cytosolic InsP6- (and InsP5-)dephosphorylating enzymes whose activity is sensitively driven by a decrease in the cellular ATP/ADP ratio, thus suggesting a role for IP6Ks as cellular adenylate energy sensors | Homo sapiens |
physiological function | InsP6 (inositol hexakisphosphate), the most abundant inositol phosphate in metazoa, is pyrophosphorylated to InsP7 [5PP-InsP5 (diphosphoinositol pentakisphosphate)] by cytosolic and nuclear IP6Ks (InsP6 kinases) and to 1PP-InsP5 by another InsP6/InsP7 kinase family. IP6Ks are also nuclear and cytosolic InsP6- (and InsP5-)dephosphorylating enzymes whose activity is sensitively driven by a decrease in the cellular ATP/ADP ratio, thus suggesting a role for IP6Ks as cellular adenylate energy sensors | Rattus norvegicus |