Cloned (Comment) | Organism |
---|---|
gene IP6K1 | Mus musculus |
gene IP6K1 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of gene Ip6k1 knockout mutant cells | Mus musculus |
additional information | generation of gene Ip6k1 knockout mutant cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | - |
Dictyostelium discoideum | 5768 | - |
endosome | - |
Mus musculus | 5768 | - |
endosome | - |
Homo sapiens | 5768 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Dictyostelium discoideum | |
Mg2+ | required | Mus musculus | |
Mg2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dictyostelium discoideum | - |
- |
- |
Homo sapiens | Q92551 | - |
- |
Mus musculus | Q6PD10 | gene IP6K1 | - |
Mus musculus C57BL/6 | Q6PD10 | gene IP6K1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | - |
Mus musculus | - |
MEF cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
inositol hexakisphosphate kinase 1 | - |
Dictyostelium discoideum |
inositol hexakisphosphate kinase 1 | - |
Mus musculus |
inositol hexakisphosphate kinase 1 | - |
Homo sapiens |
IP6K1 | - |
Dictyostelium discoideum |
IP6K1 | - |
Mus musculus |
IP6K1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Dictyostelium discoideum | |
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | in Dictyostelium discoideum, the IP7 target Ser is conserved, but the neighboring Asp and Glu residues are replaced with Thr. These Thr residues may undergo phosphorylation to mimic Asp/Glu and create a consensus site for diphosphorylation | Dictyostelium discoideum |
evolution | the absence of diphosphorylation in the IC(1-70)fragment suggests that the Ser-Pro cluster (residues 71-111) is required to facilitate pyrophosphorylation on Ser51. The site of diphosphorylation in mouse IC-2C is well conserved in human and rat, suggesting that the effect of IP7 on dynein is likely to be conserved in these species | Mus musculus |
evolution | the absence of diphosphorylation in the IC(1-70)fragment suggests that the Ser-Pro cluster (residues 71-111) is required to facilitate pyrophosphorylation on Ser51. The site of diphosphorylation in mouse IC-2C is well conserved in human and rat, suggesting that the effect of IP7 on dynein is likely to be conserved in these species | Homo sapiens |
malfunction | endosomes derived from slime mold lacking inositol diphosphates display reduced dynein-directed microtubule transport. Intermediate chain recruitment to membranes is reduced in cells lacking IP6K1 | Dictyostelium discoideum |
malfunction | mammalian cells lacking IP6K1 display defects in dynein-dependent trafficking pathways, including endosomal sorting, vesicle movement, and Golgi maintenance. Expression of catalytically active but not inactive IP6K1 reverses the defects. Intermediate chain recruitment to membranes is reduced in cells lacking IP6K1 | Homo sapiens |
malfunction | mammalian cells lacking IP6K1 display defects in dynein-dependent trafficking pathways, including endosomal sorting, vesicle movement, and Golgi maintenance. Expression of catalytically active but not inactive IP6K1 reverses the defects. Intermediate chain recruitment to membranes is reduced in cells lacking IP6K1. Decreased Tfn distribution in the ERC in Ip6k1-/- MEFs might be due to a delay in Tfn trafficking from endosomes. Tfn is held back in early endosomes in cells lacking IP6K1 | Mus musculus |
physiological function | generated predominantly by inositol hexakisphosphate kinases (IP6Ks), inositol pyrophosphates can modulate protein function by posttranslational serine diphosphorylation. Ser51 in the dynein intermediate chain is a target for diphosphorylation by IP7, and this modification promotes the interaction of the intermediate chain N-terminus with the p150Glued subunit of dynactin. Involvement of IP6Ks in dynein function, inositol pyrophosphate-mediated diphosphorylation may act as a regulatory signal to enhance dynein-driven transport. Endosomal sorting of Tfn in fibroblasts requires IP6K1 activity, the enzyme activity also is required to maintain Golgi morphology. IP6K1 activity regulates Tfn trafficking, overview | Mus musculus |
physiological function | generated predominantly by inositol hexakisphosphate kinases (IP6Ks), inositol pyrophosphates can modulate protein function by posttranslational serine diphosphorylation. Ser51 in the dynein intermediate chain is a target for diphosphorylation by IP7, and this modification promotes the interaction of the intermediate chain N-terminus with the p150Glued subunit of dynactin. Involvement of IP6Ks in dynein function, inositol pyrophosphate-mediated diphosphorylation may act as a regulatory signal to enhance dynein-driven transport. IP6K1 activity regulates Tfn trafficking, overview | Homo sapiens |
physiological function | generated predominantly by inositol hexakisphosphate kinases (IP6Ks), inositol pyrophosphates can modulate protein function by posttranslational serine diphosphorylation. Ser51 in the dynein intermediate chain is a target for diphosphorylation by IP7, and this modification promotes the interaction of the intermediate chain N-terminus with the p150Glued subunit of dynactin. Involvement of IP6Ks in dynein function, inositol pyrophosphate-mediated diphosphorylation may act as a regulatory signal to enhance dynein-driven transport. Phagosomal motility requires IP6K1. IP6K1 activity regulates Tfn trafficking, overview | Dictyostelium discoideum |