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Literature summary for 2.7.4.21 extracted from

  • Moritoh, Y.; Oka, M.; Yasuhara, Y.; Hozumi, H.; Iwachidow, K.; Fuse, H.; Tozawa, R.
    Inositol hexakisphosphate kinase 3 regulates metabolism and lifespan in mice (2016), Sci. Rep., 6, 32072 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.21

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96PC2
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Mus musculus Q8BWD2
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-

Source Tissue

Source Tissue Comment Organism Textmining
myotube high activity Homo sapiens
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myotube high activity Mus musculus
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skeletal muscle high activity Homo sapiens
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skeletal muscle high activity Mus musculus
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Synonyms

Synonyms Comment Organism
inositol hexakisphosphate kinase 3
-
 Homo sapiens
inositol hexakisphosphate kinase 3
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 Mus musculus
IP6K3
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 Homo sapiens
IP6K3
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 Mus musculus

Expression

Organism Comment Expression
Homo sapiens IP6K3 is upregulated by dexamethasone. Ip6k3 expression is elevated under diabetic, fasting, and disuse conditions in mouse skeletal muscles up
Mus musculus IP6K3 is upregulated by dexamethasone. Ip6k3 expression is elevated under diabetic, fasting, and disuse conditions in mouse skeletal muscles up

General Information

General Information Comment Organism
malfunction Ip6k3-/- mice demonstrate lower blood glucose, reduced circulating insulin, deceased fat mass, lower body weight, increased plasma lactate, enhanced glucose tolerance, lower glucose during an insulin tolerance test, and reduced muscle Pdk4 expression under normal diet conditions. Ip6k3 deletion extends animal lifespan with concomitant reduced phosphorylation of S6 ribosomal protein in the heart. In contrast, Ip6k3-/- mice show unchanged skeletal muscle mass and no resistance to the effects of high fat diet Mus musculus