Literature summary for 2.7.4.21 extracted from

Nair, V.; Gu, C.; Janoshazi, A.; Jessen, H.; Wang, H.; Shears, S.
Inositol pyrophosphate synthesis by diphosphoinositol pentakisphosphate kinase-1 is regulated by phosphatidylinositol(4,5)bisphosphate (2018), Biosci. Rep., 38, BSR20171549 .

Search for more literature for 2.7.4.21

Activating Compound

Activating Compound	Comment	Organism	Structure
PtdIns(4,5)P2	increases net 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate kinase activity 5fold	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Drosophila melanogaster	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
C8-PtdIns(4,5)P2	0.05 mM, inhibits 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate dephosphorylation by approximately 60%	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q6PFW1	cf. EC 2.7.4.24	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.007	-	pH 7.2, 37°C, 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate	-	Homo sapiens	ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate	-	r
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate	-	Homo sapiens	ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate	-	r

Subunits

Subunits	Comment	Organism
?	x * 190000, SDS-PAGE, recombinant protein	Homo sapiens

Synonyms

Synonyms	Comment	Organism
PPIP5K1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate kinase activity is dominant when PPIP5K1 is expressed in intact cells. 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate phosphatase activity prevails when the enzyme is isolated from its cellular environment. Exogenous expression of PPIP5K1 in Drosophila melanogaster S3 cells elevates levels of 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate and 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate	Homo sapiens

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Release 2023.1 (January 2023)