Reference on EC 2.7.11.15 - beta-adrenergic-receptor kinase and Organism(s) Homo sapiens and UniProt Accession P25098
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Benovic, J.L.; Stone, W.C.; Huebner, K.; Croce, C.; Caron, M.G.; Lefkowitz, R.J.
cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase
FEBS Lett.
283
122-126
1991
Homo sapiens (P25098), Homo sapiens
Chuang, T.T.; Sallese, M.; Ambrosini, G.; Parruti, G.; De Blasi, A.
High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation
J. Biol. Chem.
267
6886-6892
1992
Bos taurus, Homo sapiens, Homo sapiens (P25098)
Fushman, D.; Najmabadi-Haske, T.; Cahill, S.; Zheng, J.; LeVine, H.; Cowburn, D.
The solution structure and dynamics of the pleckstrin homology domain of G protein-coupled receptor kinase 2 (beta-adrenergic receptor kinase 1). A binding partner of Gbetagamma subunits
J. Biol. Chem.
273
2835-2843
1998
Homo sapiens (P25098)
Penn, R.B.; Benovic, J.L.
Structure of the human gene encoding the beta-adrenergic receptor kinase
J. Biol. Chem.
269
14924-14930
1994
Homo sapiens (P25098), Homo sapiens
Dunham, I.; Shimizu, N.; Roe, B.A.; Chissoe, S.; Hunt, A.R.; Collins, J.E.; Bruskiewich, R.; Beare, D.M.; Clamp, M.; Smink, L.J.; Ainscough, R.; Almeida, J.P.; Babbage, A.; Bagguley, C.; Bailey, J.; Barlow, K.; Bates, K.N.; Beasley, O.; Bird, C.P.; Blakey, S.; Bridgeman, A.M.; Buck, D.; Burgess, J.; Burrill, W.D.; O'Brien, K.P.; et al.
The DNA sequence of human chromosome 22
Nature
402
489-495
1999
Homo sapiens (P35626)
Parruti, G.; Ambrosini, G.; Sallese, M.; De Blasi, A.
Molecular cloning, functional expression and mRNA analysis of human beta-adrenergic receptor kinase 2
Biochem. Biophys. Res. Commun.
190
475-481
1993
Bos taurus, Homo sapiens (P35626), Homo sapiens
Shlemann, P.; Hekman, M.; Buchen, C.; Elce, J.S.; Lohse, M.J.
Purification and functional characterization of beta-adrenergic receptor kinase expressed in insect cells
FEBS Lett.
324
59-62
1993
Bos taurus, Homo sapiens
Petrofski, J.A.; Koch, W.J.
The beta-adrenergic receptor kinase in heart failure
J. Mol. Cell. Cardiol.
35
1167-1174
2003
Homo sapiens, Mus musculus
Iino, M.; Shibano, T.
Substrate recognition mechanism of human beta-adrenergic receptor kinase 1 based on a three-dimensional model structure
Drug Des. Discov.
14
145-155
1996
Homo sapiens
Haske, T.N.; DeBlasi, A.; LeVine, H.
An intact N terminus of the gamma subunit is required for the Gbetagamma stimulation of rhodopsin phosphorylation by human beta-adrenergic receptor kinase-1 but not for kinase binding
J. Biol. Chem.
271
2941-2948
1996
Homo sapiens
Penela, P.; Ribas, C.; Mayor, F.
Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases
Cell. Signal.
15
973-981
2003
Homo sapiens, Mus musculus, Rattus norvegicus
Oyama, N.; Urasawa, K.; Kaneta, S.; Sakai, H.; Saito, T.; Takagi, C.; Yoshida, I.; Kitabatake, A.; Tsutsui, H.
Chronic beta-adrenergic receptor stimulation enhances the expression of G-protein coupled receptor kinases, GRK2 and GRK5, in both the heart and peripheral lymphocytes
Circ. J.
69
987-990
2005
Homo sapiens, Rattus norvegicus
Williams, M.L.; Hata, J.A.; Schroder, J.; Rampersaud, E.; Petrofski, J.; Jakoi, A.; Milano, C.A.; Koch, W.J.
Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts
Circulation
109
1590-1593
2004
Homo sapiens
Yoshida, N.; Haga, K.; Haga, T.
Identification of sites of phosphorylation by G-protein-coupled receptor kinase 2 in beta-tubulin
Eur. J. Biochem.
270
1154-1163
2003
Homo sapiens
Voigt, C.; Holzapfel, H.P.; Paschke, R.
Decreased expression of G-protein coupled receptor kinase 2 in cold thyroid nodules
Exp. Clin. Endocrinol. Diabetes
113
102-106
2005
Homo sapiens
Li, Z.; Laugwitz, K.L.; Pinkernell, K.; Pragst, I.; Baumgartner, C.; Hoffmann, E.; Rosport, K.; Munch, G.; Moretti, A.; Humrich, J.; Lohse, M.J.; Ungerer, M.
Effects of two Gbetagamma-binding proteins - N-terminally truncated phosducin and beta-adrenergic receptor kinase C terminus (betaARKct)--in heart failure
Gene Ther.
10
1354-1361
2003
Homo sapiens
Rapacciuolo, A.; Suvarna, S.; Barki-Harrington, L.; Luttrell, L.M.; Cong, M.; Lefkowitz, R.J.; Rockman, H.A.
Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways
J. Biol. Chem.
278
35403-35411
2003
Homo sapiens
Eichmann, T.; Lorenz, K.; Hoffmann, M.; Brockmann, J.; Krasel, C.; Lohse, M.J.; Quitterer, U.
The amino-terminal domain of G-protein-coupled receptor kinase 2 is a regulatory Gbeta gamma binding site
J. Biol. Chem.
278
8052-8057
2003
Homo sapiens
Picascia, A.; Capobianco, L.; Iacovelli, L.; De Blasi, A.
Analysis of differential modulatory activities of GRK2 and GRK4 on Galphaq-coupled receptor signaling
Methods Enzymol.
390
337-353
2004
Homo sapiens
Usui, I.; Imamura, T.; Babendure, J.L.; Satoh, H.; Lu, J.C.; Hupfeld, C.J.; Olefsky, J.M.
G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes
Mol. Endocrinol.
19
2760-2768
2005
Homo sapiens
Willets, J.M.; Mistry, R.; Nahorski, S.R.; Challiss, R.A.
Specificity of G protein-coupled receptor kinase 6-mediated phosphorylation and regulation of single-cell M3 muscarinic acetylcholine receptor signaling
Mol. Pharmacol.
64
1059-1068
2003
Homo sapiens
Ribas, C.; Penela, P.; Murga, C.; Salcedo, A.; Garcia-Hoz, C.; Jurado-Pueyo, M.; Aymerich, I.; Mayor, F.
The G protein-coupled receptor kinase (GRK) interactome: Role of GRKs in GPCR regulation and signaling
Biochim. Biophys. Acta
1768
913-922
2007
Homo sapiens, Mammalia
Whalen, E.J.; Foster, M.W.; Matsumoto, A.; Ozawa, K.; Violin, J.D.; Que, L.G.; Nelson, C.D.; Benhar, M.; Keys, J.R.; Rockman, H.A.; Koch, W.J.; Daaka, Y.; Lefkowitz, R.J.; Stamler, J.S.
Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2
Cell
129
511-522
2007
Homo sapiens, Mus musculus
Ruiz-Gomez, A.; Mellstroem, B.; Tornero, D.; Morato, E.; Savignac, M.; Holguin, H.; Aurrekoetxea, K.; Gonzalez, P.; Gonzalez-Garcia, C.; Cena, V.; Mayor, F.; Naranjo, J.R.
G protein-coupled receptor kinase 2-mediated phosphorylation of downstream regulatory element antagonist modulator regulates membrane trafficking of Kv4.2 potassium channel
J. Biol. Chem.
282
1205-1215
2007
Homo sapiens
Takahashi, M.; Uchikado, H.; Caprotti, D.; Weidenheim, K.M.; Dickson, D.W.; Ksiezak-Reding, H.; Pasinetti, G.M.
Identification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles
J. Neuropathol. Exp. Neurol.
65
1157-1169
2006
Homo sapiens
Desai, A.N.; Salim, S.; Standifer, K.M.; Eikenburg, D.C.
Involvement of G protein-coupled receptor kinase (GRK) 3 and GRK2 in down-regulation of the alpha2B-adrenoceptor
J. Pharmacol. Exp. Ther.
317
1027-1035
2006
Homo sapiens
Hansen, J.L.; Theilade, J.; Aplin, M.; Sheikh, S.P.
Role of G-protein-coupled receptor kinase 2 in the heart--do regulatory mechanisms open novel therapeutic perspectives?
Trends Cardiovasc. Med.
16
169-177
2006
Homo sapiens
Yang, W.; Xia, S.
Mechanisms of regulation and function of G-protein-coupled receptor kinases
World J. Gastroenterol.
12
7753-7757
2006
Homo sapiens
Cohn, H.I.; Harris, D.M.; Pesant, S.; Pfeiffer, M.; Zhou, R.H.; Koch, W.J.; Dorn, G.W.; Eckhart, A.D.
Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances alpha1D-adrenergic receptor constriction
Am. J. Physiol. Heart Circ. Physiol.
295
H1695-H1704
2008
Homo sapiens (P25098), Homo sapiens
Bulcao, C.F.; Pandalai, P.K.; DSouza, K.M.; Merrill, W.H.; Akhter, S.A.
Uncoupling of myocardial beta-adrenergic receptor signaling during coronary artery bypass grafting: the role of GRK2
Ann. Thorac. Surg.
86
1189-1194
2008
Homo sapiens
Tran, T.M.; Jorgensen, R.; Clark, R.B.
Phosphorylation of the beta2-adrenergic receptor in plasma membranes by intrinsic GRK5
Biochemistry
46
14438-14449
2007
Homo sapiens
Lorenz, S.; Frenzel, R.; Paschke, R.; Breitwieser, G.E.; Miedlich, S.U.
Functional desensitization of the extracellular calcium-sensing receptor is regulated via distinct mechanisms: role of G protein-coupled receptor kinases, protein kinase C and beta-arrestins
Endocrinology
148
2398-2404
2007
Homo sapiens (P35626)
Xin, W.; Tran, T.M.; Richter, W.; Clark, R.B.; Rich, T.C.
Roles of GRK and PDE4 activities in the regulation of beta2 adrenergic signaling
J. Gen. Physiol.
131
349-364
2008
Homo sapiens
Mayer, G.; Wulffen, B.; Huber, C.; Brockmann, J.; Flicke, B.; Neumann, L.; Hafenbradl, D.; Klebl, B.M.; Lohse, M.J.; Krasel, C.; Blind, M.
An RNA molecule that specifically inhibits G-protein-coupled receptor kinase 2 in vitro
RNA
14
524-534
2008
Homo sapiens
Kahsai, A.; Zhu, S.; Fenteany, G.
G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells
Biochim. Biophys. Acta
1803
300-310
2010
Homo sapiens
DSouza, K.M.; Malhotra, R.; Philip, J.L.; Staron, M.L.; Theccanat, T.; Jeevanandam, V.; Akhter, S.A.
G protein-coupled receptor kinase-2 is a novel regulator of collagen synthesis in adult human cardiac fibroblasts
J. Biol. Chem.
286
15507-15516
2011
Homo sapiens
Valanne, S.; Myllymaeki, H.; Kallio, J.; Schmid, M.R.; Kleino, A.; Murumaegi, A.; Airaksinen, L.; Kotipelto, T.; Kaustio, M.; Ulvila, J.; Esfahani, S.S.; Engstroem, Y.; Silvennoinen, O.; Hultmark, D.; Parikka, M.; Raemet, M.
Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling
J. Immunol.
184
6188-6198
2010
Danio rerio, Drosophila melanogaster, Homo sapiens
Tesmer, J.J.; Tesmer, V.M.; Lodowski, D.T.; Steinhagen, H.; Huber, J.
Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol
J. Med. Chem.
53
1867-1870
2010
Homo sapiens (P25098), Homo sapiens
Asai, D.; Murata, M.; Toita, R.; Kawano, T.; Nakashima, H.; Kang, J.H.
Role of amino acid residues surrounding the phosphorylation site in peptide substrates of G protein-coupled receptor kinase 2 (GRK2)
Amino Acids
48
2875-2880
2016
Homo sapiens
Inagaki, S.; Ghirlando, R.; Vishnivetskiy, S.A.; Homan, K.T.; White, J.F.; Tesmer, J.J.; Gurevich, V.V.; Grisshammer, R.
G protein-coupled receptor kinase 2 (GRK2) and 5 (GRK5) exhibit selective phosphorylation of the neurotensin receptor in vitro
Biochemistry
54
4320-4329
2015
Homo sapiens
Asai, D.; Toita, R.; Murata, M.; Katayama, Y.; Nakashima, H.; Kang, J.H.
Peptide substrates for G protein-coupled receptor kinase 2
FEBS Lett.
588
2129-2132
2014
Homo sapiens
So, C.H.; Michal, A.; Komolov, K.E.; Luo, J.; Benovic, J.L.
G protein-coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor-promoted centrosomal separation
Mol. Biol. Cell
24
2795-2806
2013
Homo sapiens
Asai, D.; Murata, M.; Toita, R.; Kawano, T.; Nakashima, H.; Kang, J.
A high-affinity peptide substrate for G protein-coupled receptor kinase 2 (GRK2)
Amino Acids
51
973-976
2019
Homo sapiens
Kang, J.H.; Toita, R.; Kawano, T.; Murata, M.; Asai, D.
Design of substrates and inhibitors of G protein-coupled receptor kinase 2 (GRK2) based on its phosphorylation reaction
Amino Acids
52
863-870
2020
Homo sapiens
Kuwasako, K.; Sekiguchi, T.; Nagata, S.; Jiang, D.; Hayashi, H.; Murakami, M.; Hattori, Y.; Kitamura, K.; Kato, J.
Inhibitory effects of two G protein-coupled receptor kinases on the cell surface expression and signaling of the human adrenomedullin receptor
Biochem. Biophys. Res. Commun.
470
894-899
2016
Homo sapiens (P25098)
Xu, G.; Gaul, M.D.; Liu, Z.; DesJarlais, R.L.; Qi, J.; Wang, W.; Krosky, D.; Petrounia, I.; Milligan, C.M.; Hermans, A.; Lu, H.R.; Huang, D.Z.; Xu, J.Z.; Spurlino, J.C.
Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor
Bioorg. Med. Chem. Lett.
30
127602
2020
Homo sapiens (P25098), Homo sapiens
Ye, W.; Yang, S.; Zhang, L.; Deng, Z.; Li, W.; Zhang, J.; Zhang, L.; Yun, Y.; Chen, A.; Cao, D.
Multistep virtual screening for rapid identification of G protein-coupled receptors kinase 2 inhibitors for heart failure treatment
Chemometr. Intell. Lab. Syst.
185
32-40
2019
Homo sapiens (P25098)
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