Literature summary for 2.7.11.15 extracted from

Valanne, S.; Myllymaeki, H.; Kallio, J.; Schmid, M.R.; Kleino, A.; Murumaegi, A.; Airaksinen, L.; Kotipelto, T.; Kaustio, M.; Ulvila, J.; Esfahani, S.S.; Engstroem, Y.; Silvennoinen, O.; Hultmark, D.; Parikka, M.; Raemet, M.
Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling (2010), J. Immunol., 184, 6188-6198.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell membrane	-	Drosophila melanogaster	-	-
cell membrane	-	Homo sapiens	-	-
cytoplasm	-	Drosophila melanogaster	5737	-
cytoplasm	-	Homo sapiens	5737	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Drosophila melanogaster	Gprk2 interacts with the Drosophila IkB homolog Cactus	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	-	-	-
Drosophila melanogaster	-	-	-
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	Gprk2 interacts with the Drosophila IkB homolog Cactus	Drosophila melanogaster	?	-	?

Synonyms

Synonyms	Comment	Organism
Gprk2	-	Drosophila melanogaster
GRK5	-	Homo sapiens
GRK5	-	Danio rerio

General Information

General Information	Comment	Organism
malfunction	morpholino silencing of the zebrafish ortholog of Gprk2 in fish embryos causes impaired cytokine expression after Escherichia coli infection	Danio rerio
malfunction	RNA silencing of GRK5 in HeLa cells impairs NF-kappaB reporter activity	Homo sapiens
malfunction	using a genome-wide RNAi screen Grk2 is identified as a conserved regulator of NF-kappaB signaling	Drosophila melanogaster

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Release 2023.1 (January 2023)