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Literature summary for 2.7.11.15 extracted from

  • Ye, W.; Yang, S.; Zhang, L.; Deng, Z.; Li, W.; Zhang, J.; Zhang, L.; Yun, Y.; Chen, A.; Cao, D.
    Multistep virtual screening for rapid identification of G protein-coupled receptors kinase 2 inhibitors for heart failure treatment (2019), Chemometr. Intell. Lab. Syst., 185, 32-40 .
No PubMed abstract available
Search for more literature for 2.7.11.15

Inhibitors

Inhibitors Comment Organism Structure
(6R)-6-([[(1S)-1-(5-fluoro-2-methoxyphenyl)ethyl]amino]methyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
-
 Homo sapiens
1-[(3R)-1-benzylpyrrolidin-3-yl]-3-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]urea
-
 Homo sapiens
2-[(2-amino-2-oxoethyl)(propan-2-yl)amino]-N-[(1S)-1-(naphthalen-2-yl)ethyl]acetamide
-
 Homo sapiens
2-[(3S)-3-[(phenylsulfanyl)methyl]pyrrolidin-1-yl]-N-(pyridin-3-ylmethyl)acetamide
-
 Homo sapiens
3-cyano-N-[[(3R)-1-(thiophen-2-ylmethyl)piperidin-3-yl]methyl]benzamide
-
 Homo sapiens
4-acetyl-N-[(2S)-2-(dimethylamino)-2-(4-methoxyphenyl)ethyl]-1H-pyrrole-2-carboxamide
-
 Homo sapiens
4-acetyl-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-methylpropyl]-1H-pyrrole-2-carboxamide
-
 Homo sapiens
4-acetyl-N-[[(3R)-1-benzylpiperidin-3-yl]methyl]-1H-pyrrole-2-carboxamide
-
 Homo sapiens
5-(4-fluorophenyl)-N-[[(3S,5R,8aR)-hexahydro-1H-pyrrolo[2,1-c][1,4]oxazin-3-yl]methyl]-5-oxopentanamide
-
 Homo sapiens
5-fluoro-N-(imidazo[1,2-a]pyridin-2-ylmethyl)-2-methoxybenzamide
-
 Homo sapiens
CCG224406
-
 Homo sapiens
CCG258208
-
 Homo sapiens
GSK180736A
-
 Homo sapiens
N-(4-acetylphenyl)-N2-[(3-chlorophenyl)methyl]-N2-methyl-L-alaninamide
-
 Homo sapiens
N-(4-cyanophenyl)-3-[4-(4-hydroxyphenyl)-3,6-dihydropyridin-1(2H)-yl]propanamide
-
 Homo sapiens
N-[(2R)-2-(3,4-dihydroisoquinolin-2(1H)-yl)butyl]-N'-(1-ethyl-1H-pyrazol-4-yl)urea
-
 Homo sapiens
N-[(2R)-2-(3,4-dihydroisoquinolin-2(1H)-yl)propyl]-N'-[(2S)-1-(1H-pyrrol-1-yl)propan-2-yl]urea
-
 Homo sapiens
N-[1-[benzyl(methyl)amino]-2-methylpropan-2-yl]-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxamide
-
 Homo sapiens
N2-methyl-N2-[[4-(methylsulfanyl)phenyl]methyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-L-alaninamide
-
 Homo sapiens
N3-[(6-fluoroquinolin-8-yl)methyl]-N-[(pyridin-3-yl)methyl]-beta-alaninamide
-
 Homo sapiens
paroxetine
-
 Homo sapiens
Takeda CMPD 101
-
 Homo sapiens
Takeda CMPD 103A
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [beta-adrenergic receptor] Homo sapiens
-
 ADP + phospho-[beta-adrenergic receptor]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P25098
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [beta-adrenergic receptor]
-
 Homo sapiens ADP + phospho-[beta-adrenergic receptor]
-
 ?

Synonyms

Synonyms Comment Organism
G protein-coupled receptors kinase 2
-
 Homo sapiens
GRK2
-
 Homo sapiens