Cloned (Comment) | Organism |
---|---|
adenovirus-mediated gene transfer and expression of inhibitor betaARKct in primary myocytes isolated from hearts of patients in the end-stage of heart failure undergoing heart transplantation, betaARK1 activity is inhibited but beta-adrenergic signaling and contractile function are improved | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
betaARKct | the isolated C-terminal sequence of the enzyme acts as a peptide inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | betaARK1 inhibition improves beta-adrenergic signaling and contractile function in failing human myocytes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
myocardium | - |
Homo sapiens | - |
myocyte | primary isolated from hearts of patients in the end-stage of heart failure undergoing heart transplantation | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | betaARK1 inhibition improves beta-adrenergic signaling and contractile function in failing human myocytes | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-adrenergic receptor kinase | - |
Homo sapiens |
betaARK1 | - |
Homo sapiens |